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Ruben Sebastian

@rubensebas.bsky.social
563 followers 946 following 143 posts

Biotech investor, operator & BD | Drug development | EIR @mskcancercenter.bsky.social |📍New York www.linkedin.com/in/rubensebastianp…

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Ruben Sebastian @rubensebas.bsky.social · 20/04/2026
We’re witnessing impressive advances in pancreatic cancer! A pancreatic cancer mRNA vaccine shows a very strong and durable immune response in a Phase 1 trial. New 6-year data are being presented today at #AACR2026 @mskcancercenter.bsky.social www.nbcnews.com/health/cance...
nbcnews.com
Pancreatic cancer mRNA vaccine shows lasting results in an early trial
Scientists caution that more research is needed, but nearly all of the patients who responded to the personalized vaccine are still alive six years later.
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Ruben Sebastian @rubensebas.bsky.social · 20/04/2026
Lilly to acquire Kelonia to advance in vivo CAR-T cell therapies for $3.25 billion upfront and up to $7 billion Kelonia's lead program is an i.v. gene therapy that generates anti-BCMA CAR-T cells in vivo and is currently in Ph1 for r/r multiple myeloma investor.lilly.com/news-release...
investor.lilly.com
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Ruben Sebastian @rubensebas.bsky.social · 25/03/2026
What a few days of M&A activity, with good friends involved. - Today: Merck to acquire Terns (allosteric TKI, leukemia) for $6.7B - Monday: Gilead to acquire Ouro (BCMA TCE, I&I) for $2.2B - Last week: Novartis to acquire Synnovation’s SNV4818 (PI3Ki, breast cancer) for $3B
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Ruben Sebastian @rubensebas.bsky.social · 12/02/2026
Belén Garijo, departing CEO of Merck KGaA, will take the helm at #Sanofi as its new CEO starting in April 2026 www.sanofi.com/en/media-roo...
sanofi.com
Press Release: Belén Garijo to become Chief Executive Officer of Sanofi
Belén Garijo to become Chief Executive Officer of Sanofi Paris, February 12, 2026. Sanofi's Board of Directors met on February 11, 2026, and decided not to renew the Director mandate of Paul Hudson.....
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Ruben Sebastian @rubensebas.bsky.social · 17/01/2026
European biotech Agomab files for a #Nasdaq IPO Will we see a surge of news post #JPM26? www.bloomberg.com/news/article...
bloomberg.com
Belgian Immune System Drugmaker AgomAb Files for US IPO
AgomAb Therapeutics NV filed for a initial public offering in the US to help fund trials of its drugs to treat immune and inflammation diseases.
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Ruben Sebastian @rubensebas.bsky.social · 12/01/2026
Eikon joins the IPO queue after raising over $1B in private funding since 2019 #JPM26 Aktis (now $AKTS) raised $318M in 2026’s first biotech IPO last week. Predictions for 2026 biotech IPOs are in the 30-40 range www.biopharmadive.com/news/eikon-i...
biopharmadive.com
Eikon, a high-profile startup led by Merck vets, seeks an IPO
Run by Roger Perlmutter and backed by more than $1 billion in private funding, Eikon will use the IPO proceeds to advance a group of experimental cancer drugs.
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Ruben Sebastian @rubensebas.bsky.social · 12/01/2026
Another deal coming from $NVS this morning #JPM26 Novartis has entered into a worldwide license agreement with PepLib for an undisclosed peptide-based radioligand therapy asset $50M upfront + undisclosed milestones/royalties www.peplib.com/news_detail/...
peplib.com
Zonsen PepLib Biotech and Novartis Sign Worldwide License Agreement regarding Radioligand Therapy Asset-Zonsen PepLib Biotech Inc.
Zonsen PepLib Biotech Inc. Zonsen PepLib Biotech Inc. is a high-tech biopharmaceutical enterprise that is dedicated to advancing global innovation in the discovery of new peptide drugs. Founded in Sep...
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Ruben Sebastian @rubensebas.bsky.social · 12/01/2026
NVIDIA $NVDA and Lilly $LLY are all-in on AI powered drug discovery #JPM26 investor.lilly.com/news-release...
investor.lilly.com
NVIDIA and Lilly Announce Co-Innovation AI Lab to Reinvent Drug Discovery In the Age of AI | Eli Lilly and Company
The Investor Relations website contains information about Eli Lilly and Company's business for stockholders, potential investors, and financial analysts.
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Ruben Sebastian @rubensebas.bsky.social · 12/01/2026
SciNeuro and Novartis $NVS enter into a licensing and collaboration agreement for next-gen therapeutics to treat #Alzheimers Amyloid beta targeted antibody program with a proprietary BBB shuttle technology $165M upfront and up to $1.5B total deal #JPM26 www.prnewswire.com/news-release...
prnewswire.com
SciNeuro and Novartis Enter into a Licensing and Collaboration Agreement for Next Generation Therapeutics to Treat Alzheimer's Disease
/PRNewswire/ -- SciNeuro grants Novartis an exclusive worldwide license to develop SciNeuro's novel antibody program that leverages a proprietary shuttle...
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Ruben Sebastian @rubensebas.bsky.social · 12/01/2026
AbbVie $ABBV and RemeGen announce exclusive ex China licensing agreement to develop a PD-1/VEGF bispecific antibody for advanced solid tumors $650M upfront and up to $4.95B total deal #JPM26 news is cautiously warming up news.abbvie.com/2026-01-12-A...
news.abbvie.com
AbbVie and RemeGen Announce Exclusive Licensing Agreement to Develop A Novel Bispecific Antibody for Advanced Solid Tumors
- RC148 is a novel PD-1/VEGF bispecific antibody being evaluated in multiple advanced solid tumors including certain lung cancers NORTH CHICAGO, Ill. and YANTAI, China, Jan. 12, 2026 /PRNewswire/...
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Ruben Sebastian @rubensebas.bsky.social · 09/01/2026
Tick tock $RVMD #JPM26 www.ft.com/content/93b4...
ft.com
Merck in talks to buy cancer drugmaker Revolution Medicines for up to $32bn
US company is attempting to acquire the maker of a new treatment for pancreatic cancer
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Ruben Sebastian @rubensebas.bsky.social · 09/01/2026
NRG Therapeutics is now a clinical-stage company! First participants dosed in the FIH trial of lead candidate NRG5051 developed for #ALS and #Parkinsons This great news comes with the tailwind of the oversubscribed Series B we backed last summer. #JPM26 www.nrgtherapeutics.com/news/22/51/N...
nrgtherapeutics.com
NRG Therapeutics
energizing drug discovery in neurodegenerative diseases.
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Ruben Sebastian @rubensebas.bsky.social · 09/01/2026
What a year for Aboleris Pharma, now reporting the first patient dosed in Part II of its Phase 1 study of ABO21009, a first-in-class anti-CD45RC mAb for rheumatoid arthritis and other #autoimmune diseases. Flawless clinical execution by the team! #JPM26! www.prnewswire.com/news-release...
prnewswire.com
AbolerIS Pharma Announces First Patient Dosed in Part II of Phase 1 Study of ABO21009, a Novel Anti-CD45RC Antibody, for Rheumatoid Arthritis
/PRNewswire/ -- AbolerIS Pharma ("AbolerIS"), a clinical-stage biopharmaceutical company committed to improving the lives of people suffering from autoimmune...
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Ruben Sebastian @rubensebas.bsky.social · 07/01/2026
Lilly/Ventyx is the second biotech acquisition of the year, after Amgen $AMGN acquisition of UK protein degradation startup Dark Blue Therapeutics for up to $840 million. Dark Blue was developing a small molecule degrader of MLLT1/3 for AML. #JPM26 www.amgen.com/newsroom/pre...
amgen.com
AMGEN ACQUIRES DARK BLUE THERAPEUTICS, BOLSTERING ONCOLOGY PIPELINE| Amgen
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Ruben Sebastian @rubensebas.bsky.social · 07/01/2026
Lilly $LLY is buying Ventyx Bio $VTYX for $1.2 billion to advance oral therapies targeting inflammatory-mediated diseases. The #JPM26 news flow dance has started investor.lilly.com/news-release...
investor.lilly.com
Lilly to acquire Ventyx Biosciences to advance oral therapies targeting inflammatory-mediated diseases | Eli Lilly and Company
The Investor Relations website contains information about Eli Lilly and Company's business for stockholders, potential investors, and financial analysts.
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Ruben Sebastian @rubensebas.bsky.social · 17/12/2025
Great time celebrating the holidays at the New York Stock Exchange last night. It was a pleasure to join many colleagues from the #biotech finance & business communities on the iconic NYSE floor. I’m gradually becoming a true New Yorker! Happy holidays everyone! 🥂✨
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Ruben Sebastian @rubensebas.bsky.social · 10/12/2025
The dance has begun $ABVX #Abivax #biotech #pharma www.reuters.com/business/hea...
reuters.com
French biotech Abivax's shares climb on Eli Lilly bid rumors
French biotech company Abivax's shares rose by over 20% on Wednesday on market rumours that U.S. pharma giant Eli Lilly could make an offer for the business.
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Ruben Sebastian @rubensebas.bsky.social · 08/12/2025
Paramount launches a hostile takeover bid for Warner Bros Discovery worth $108.4 billion. It seems that the recent competitive bid in biopharma between $PFE and $NVO for $MTSR has served as an early Christmas inspiration for some CEOs… www.cnn.com/2025/12/08/b...
cnn.com
Paramount launches a hostile takeover bid for Warner Bros. Discovery | CNN Business
Paramount has gone straight to Warner Bros. Discovery’s shareholders with an all-cash offer in an extraordinary endeavor to gain control of Hollywood’s most sought-after prize — a bid that Netflix bea...
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Ruben Sebastian @rubensebas.bsky.social · 08/12/2025
Great news reported today from two of my #portfolio companies: $KYMR (+107% over the last 6 months) and $DYN (+63% same period). Stocks are trading well on strong clinical redouts, with public markets now rewarding good data. You can own stocks into clinical catalysts and be compensated for it
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Ruben Sebastian @rubensebas.bsky.social · 08/12/2025
$DYN announces positive topline results from the registrational expansion cohort of its Ph1/2 trial of z-rostudirsen (TfR1 targeted morpholino oligomer) in Duchenne muscular dystrophy. On track to submit for US accelerated approval in 2Q26 #portfolioCo investors.dyne-tx.com/news-release...
investors.dyne-tx.com
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Ruben Sebastian @rubensebas.bsky.social · 08/12/2025
$KYMR announces positives results from Ph1b of KT-621 (oral STAT6 degrader) in atopic derm. Ph2b in AD is ongoing and expansion to asthma expected in 1Q26. Shares jumped 35% in premarket. Oral therapies with biologics-like activity are becoming a reality! investors.kymeratx.com/news-release...
investors.kymeratx.com
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Ruben Sebastian @rubensebas.bsky.social · 05/12/2025
Netflix to acquire Warner Bros Discovery for $82.7 billion. The main jewels are Warner’s film and television studios, HBO Max and HBO This deal has clearly nothing to do with biopharma, but we all love Game of Thrones, Succession, Friends etc. Happy Friday everyone! www.nbcnews.com/business/med...
nbcnews.com
Netflix agrees to buy Warner Bros. and HBO Max, creating streaming titan
If approved by Trump administration regulators, the deal would lead to a new entertainment and technology behemoth.
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Ruben Sebastian @rubensebas.bsky.social · 24/11/2025
It’s tiiiiime!!! 😉 Atlas Venture 2025 Year In Review www.youtube.com/watch?v=JrNo...
youtube.com
Atlas Venture Year in Review 2025 - B. Booth
YouTube video by Atlas Venture
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Ruben Sebastian @rubensebas.bsky.social · 24/11/2025
Last week we saw a resurgence of #biotech M&A activity: - J&J to buy Halda (RIPTAC platform for prostate cancer/solid tumors) for $3.05B - Merck to buy Cidara (antiviral for influenza) for $9.2B - AstraZeneca bought SixPeaks Bio (obesity) for $300M www.jnj.com/media-center...
jnj.com
Johnson & Johnson set to revolutionize the treatment of cancer with the acquisition of Halda Therapeutics
Acquisition provides highly differentiated clinical-stage treatment for prostate cancer, building on Johnson & Johnson’s nearly two decades of innovation in the disease area Lead asset shows potential...
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Ruben Sebastian @rubensebas.bsky.social · 07/10/2025
Today is a very sad day. Sir John Gurdon was a titan of developmental biology. Gurdon’s foundational research, culminating in his Nobel Prize recognition in 2012, was a great source of inspiration to me as a university student at the time www.cam.ac.uk/research/new...
cam.ac.uk
Nobel Laureate Professor Sir John Gurdon dies aged 92
It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.
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Ruben Sebastian @rubensebas.bsky.social · 06/10/2025
Great recognition to a fundamental discovery that reshaped modern #immunology. Congrats to the laureates! However, imho the Nobel committee missed the chance to acknowledge an additional key contributor to the understanding of #Foxp3 and #Treg functionality
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Ruben Sebastian @rubensebas.bsky.social · 30/09/2025
Elegant piece by @cedric-blanpain.bsky.social in @natrevcancer.nature.com especially highlighting the recent advances of potential #therapeutic strategies to target #EMT tumor states www.nature.com/articles/s41...
nature.com
Identification, functional insights and therapeutic targeting of EMT tumour states - Nature Reviews Cancer
In this Review, Dong and Blanpain outline our current understanding of the epithelial-to-mesenchymal transition in cancer, which we now know is not a simple binary switch but the existence of a series of different tumour states. The authors also discuss the implications of this knowledge for pharmacologically targeting epithelial-to-mesenchymal transition to overcome therapy resistance.
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Ruben Sebastian @rubensebas.bsky.social · 15/09/2025
Monte Rosa Therapeutics $GLUE announces collaboration with Novartis for molecular glue #degraders to treat immune-mediated diseases 2nd partnership between the 2 companies, now including $120M upfront and up to $5.7 billion total deal #biotech #immunology www.globenewswire.com/news-release...
globenewswire.com
Monte Rosa Therapeutics Announces Collaboration with Novartis for Degraders to Treat Immune-mediated Diseases
Monte Rosa Therapeutics Announces Collaboration with Novartis for Degraders to Treat Immune-mediated Diseases ...
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Ruben Sebastian @rubensebas.bsky.social · 08/09/2025
Thrilled to have contributed to the oversubscribed $67M Series B round of NRG Therapeutics NRG is pioneering first-in-class therapies targeting #mitochondrial dysfunction for the treatment of devastating #neurodegenerative diseases such as ALS and Parkinson’s www.globenewswire.com/news-release...
globenewswire.com
NRG Therapeutics Announces Oversubscribed £50m ($67m) Series B Financing to Deliver Clinical Data in Parkinson’s and Proof of Concept in ALS/MND
Oversubscribed £50m Series B led by SV Health Investors’ Dementia Discovery Fund, alongside other new investors British Business Bank, M Ventures, Novartis...
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Ruben Sebastian @rubensebas.bsky.social · 25/08/2025
Gilead's Kite enters the in vivo #CART space with $350 million Interius buyout #biotech #pharma #celltherapy www.kitepharma.com/news/press-r...
kitepharma.com
Kite to Acquire Interius BioTherapeutics to Advance In Vivo Platform
Kite to Acquire Interius BioTherapeutics to Advance In Vivo Platform
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Ruben Sebastian @rubensebas.bsky.social · 25/08/2025
And the whispers were going in the right direction: AbbVie to acquire Gilgamesh bretisilocin, a novel, investigational therapy for major #depressive disorder, expanding its #psychiatry pipeline Total deal up to $1.2 billion #pharma #innovation #biotech news.abbvie.com/2025-08-25-A...
news.abbvie.com
AbbVie to Acquire Gilgamesh Pharmaceuticals' Bretisilocin, a Novel, Investigational Therapy for Major Depressive Disorder, Expanding Psychiatry Pipeline
Gilgamesh's lead asset, bretisilocin (GM-2505), is a potential best-in-class psychedelic compound currently in Phase 2 development for the treatment of major depressive disorder (MDD)....
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Ruben Sebastian @rubensebas.bsky.social · 18/08/2025
Novo’s Wegovy becomes first #GLP1 drug approved for MASH The only other therapy approved for #MASH, Madrigal Rezdiffra, has gotten off to a stronger-than-expected sales start: $180m in net sales in 2024, $350m over H1 2025, $1b projected annual sales in 2026 www.biopharmadive.com/news/novo-we...
biopharmadive.com
Novo’s Wegovy becomes first GLP-1 drug approved for MASH
The FDA clearance sets Novo’s medicine up a market battle with Madrigal Pharmaceuticals’ fast-selling Rezdiffra.
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Ruben Sebastian @rubensebas.bsky.social · 18/08/2025
Boehringer Ingelheim and Palatin Technologies to develop potential first-in-class #melanocortin receptor targeted treatment for patients with #retinal diseases Total deal up to €280 million www.globenewswire.com/news-release...
globenewswire.com
Boehringer Ingelheim and Palatin Technologies to develop potential first-in-class melanocortin receptor targeted treatment for patients with retinal diseases
Boehringer and Palatin Technologies team up to develop potential first-in-class melanocortin receptor targeted treatment for patients with retinal...
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Ruben Sebastian @rubensebas.bsky.social · 18/08/2025
Skyhawk Therapeutics announces #strategic collaboration with Merck KGaA to discover novel #RNA targeting small molecules for #neurological disorders Total deal value exceeds $2 billion www.prnewswire.com/news-release...
prnewswire.com
Skyhawk Therapeutics Announces Strategic Collaboration with Merck KGaA, Darmstadt, Germany to Discover Novel RNA-Targeting Small Molecules for Neurological Disorders
/PRNewswire/ -- Skyhawk Therapeutics, Inc., a leader in the discovery and development of small molecules that modulate RNA expression, today announces a...
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Ruben Sebastian @rubensebas.bsky.social · 18/08/2025
Daiichi Sankyo and Merck B7-H3 targeted #ADC I-DXd (ifinatamab deruxtecan) granted FDA #Breakthrough Therapy Designation for pretreated extensive-stage SCLC www.merck.com/news/ifinata...
merck.com
Ifinatamab Deruxtecan Granted Breakthrough Therapy Designation by U.S. FDA for Patients with Pretreated Extensive-Stage Small Cell Lung Cancer - Merck.com
Data from IDeate-Lung01 trial will be presented at upcoming IASLC 2025 World Conference on Lung Cancer First Breakthrough Therapy Designation for Daiichi Sankyo and Merck’s ifinatamab deruxtecan based...
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Ruben Sebastian @rubensebas.bsky.social · 18/08/2025
BMS EGFRxHER3 #bispecific #ADC iza-bren granted FDA #Breakthrough Therapy Designation for previously treated advanced EGFR-mutated NSCLC news.bms.com/news/details...
news.bms.com
Izalontamab Brengitecan (EGFRxHER3 ADC) Granted Breakthrough Therapy Designation by U.S. FDA for Patients with Previously Treated Advanced EGFR-Mutated Non-Small Cell Lung Cancer
Izalontamab Brengitecan (EGFRxHER3 ADC) Granted Breakthrough Therapy Designation by U.S. FDA for Patients with Previously Treated Advanced EGFR-Mutated Non-Small Cell Lung Cancer Redmond, Washington a...
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Ruben Sebastian @rubensebas.bsky.social · 18/08/2025
Pfizer’s #sicklecell disease drug inclacumab (P-selectin inhibitor) has flunked a key phase 3 test, the latest blow to the pharma’s $5.4 billion acquisition of Global Blood Therapeutics Thrive-131 missed its primary endpoint at 48 weeks www.pfizer.com/news/announc...
pfizer.com
Pfizer Provides Update on Phase 3 Inclacumab Study for the Treatment of People with Sickle Cell Disease | Pfizer
NEW YORK, Friday, August 15, 2025 – Pfizer Inc. (NYSE: PFE) today announced results from the Phase 3 THRIVE-131 study evaluating inclacumab, an investigational P-selectin inhibitor, in patients 16 yea...
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Ruben Sebastian @rubensebas.bsky.social · 14/08/2025
Encouraging phase 1 results of an off-the-shelf, lymph node targeted #cancer vaccine targeting common #KRAS mutations (G12D, G12R) in pancreatic and colorectal cancer from Elicio $ELTX, @mskcancercenter.bsky.social, @mdanderson.bsky.social‪‬, UCLA & clinical collabs www.nature.com/articles/s41...
nature.com
Lymph node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: phase 1 AMPLIFY-201 trial final results - Nature Medicine
In the final analysis of a phase 1 trial evaluating a lymph node-targeting mutant KRAS peptide vaccine combined with CpG in the adjuvant setting for patients with KRAS mutant pancreatic or colorectal ...
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Ruben Sebastian @rubensebas.bsky.social · 14/08/2025
Superluminal Medicines announces collaboration with Eli #Lilly to advance small molecule #therapeutics (undisclosed GPCR targets) for #cardiometabolic diseases and #obesity Total deal of up to $1.3 billion www.prnewswire.com/news-release...
prnewswire.com
Superluminal Medicines Announces Collaboration with Eli Lilly and Company to Advance Small Molecule Therapeutics for Cardiometabolic Diseases and Obesity
/PRNewswire/ -- Superluminal Medicines, a drug discovery company integrating AI/ML, protein dynamics, and structural biology to rapidly unlock the most...
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Ruben Sebastian @rubensebas.bsky.social · 12/08/2025
Bayer and Kumquat Biosciences enter global exclusive #license and #collaboration to develop and commercialize Kumquat's #KRAS G12D inhibitor. Phase 1a study will initiate H2 2025 Total deal up to $1.3 billion #oncology #pharma #oncogene #therapeutics www.prnewswire.com/news-release...
prnewswire.com
Bayer and Kumquat Biosciences enter global exclusive license and collaboration in precision oncology
/PRNewswire/ -- Bayer and Kumquat Biosciences Inc., a clinical-stage biotech company founded by pioneers of the KRAS pathway, today announced that they have...
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Ruben Sebastian @rubensebas.bsky.social · 11/08/2025
Novartis is closer to bringing the first targeted #drug to market for Sjogren’s disease Ianalumab, a dual mechanism, #Bcell depleting antibody that targets BAFF-R, originated from #Morphosys collaboration #immunology #innovation #biopharma www.novartis.com/news/media-r...
novartis.com
Novartis announces both ianalumab Phase III clinical trials met primary endpoint in patients with Sjögren’s disease
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Ruben Sebastian @rubensebas.bsky.social · 31/07/2025
Abbvie is in talks to acquire Gilgamesh Pharmaceuticals, a biotech company that’s developing next-generation psychedelic compounds for mental health disorders www.reuters.com/legal/transa...
reuters.com
AbbVie in talks to acquire Gilgamesh Pharmaceuticals, Bloomberg News reports
Drugmaker AbbVie is in talks to acquire privately-held mental health therapeutics company Gilgamesh Pharmaceuticals in a deal worth about $1 billion, Bloomberg News reported on Wednesday, citing people familiar with the matter.
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Ruben Sebastian @rubensebas.bsky.social · 28/07/2025
GSK and Hengrui enter agreements to develop up to 12 innovative drugs across respiratory, #immunology & #inflammation and #oncology Includes license for potential best-in-class PDE3/4 inhibitor in clinical dev for COPD $500 million upfront, up to $12 billion total deal www.gsk.com/en-gb/media/...
gsk.com
GSK and Hengrui Pharma enter agreements to develop up to 12 innovative medicines across Respiratory, Immunology & Inflammation and Oncology | GSK
Includes license for potential best-in-class PDE3/4 inhibitor (HRS-9821) in clinical development for treatment of COPD
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Ruben Sebastian @rubensebas.bsky.social · 25/07/2025
Gate enters into a collab & license agreement w #Lilly to discover/develop molecular gate medicines > #smallmolecules that can eliminate disease-causing proteins modulating the secretory translocon Undisclosed upfront & equity investment, total deal up to $856m www.businesswire.com/news/home/20...
businesswire.com
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Ruben Sebastian @rubensebas.bsky.social · 24/07/2025
French biotech Abivax $ABVX has announced positive Phase 3 results for obefazimod, its first-in-class oral miR-124 enhancer, in moderate to severely active ulcerative colitis ir.abivax.com/news-release...
ir.abivax.com
Abivax Announces Positive Phase 3 Results from Both ABTECT 8-Week Induction Trials Investigating Obefazimod, its First-in-Class Oral miR-124 Enhancer, in Moderate to Severely Active Ulcerative Colitis...
Abivax Announces Positive Phase 3 Results from Both ABTECT 8-Week Induction Trials Investigating Obefazimod, its First-in-Class Oral miR-124 Enhancer, in Moderate to Severely Active Ulcerative Colitis...
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Ruben Sebastian @rubensebas.bsky.social · 24/07/2025
Roche has axed one of the #obesity assets from its $2.7 billion Carmot buyout. The dropped candidate, CT-173, is a long-acting PYY analog in preclinical dev Carmot’s former lead asset CT-388, a GLP-1/GIP agonist, is pending a go decision for Ph3 in obesity www.fiercebiotech.com/biotech/roch...
fiercebiotech.com
Roche axes Carmot obesity asset, 3 cancer drugs in R&D clear-out
Roche has axed one of the obesity assets from its $2.7 billion Carmot Therapeutics
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Ruben Sebastian @rubensebas.bsky.social · 24/07/2025
Matchpoint Therapeutics announces exclusive option and license agreement with #Novartis to develop oral #covalent inhibitors directed at an undisclosed transcription factor linked to several inflammatory diseases $60 million upfront and up to $1 billion total deal matchpointtx.com/news/matchpo...
matchpointtx.com
Matchpoint Therapeutics Announces Exclusive Option and License Agreement with Novartis to Develop Oral Inhibitors for Multiple Inflammatory Diseases - Matchpoint Therapeutics
Matchpoint Therapeutics Announces Exclusive Option and License Agreement with Novartis to Develop Oral Inhibitors for Multiple Inflammatory Diseases
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Ruben Sebastian @rubensebas.bsky.social · 23/07/2025
Dispatch Bio emerges to develop a sequential gene & cell therapy for solid tumors 1) Engineered virus targets cancer cells > exposes antigen 🔥 2) CAR-T seeks out the antigen 3) Cancer cells are killed > release viral particles + antigen > flag nearby tumor > ♻️ www.biopharmadive.com/news/disptac...
biopharmadive.com
Dispatch emerges with $216M and plans for a ‘universal’ solid tumor therapy
The startup is using elements of gene and cell therapy to create medicines that could be useful against an array of tough-to-treat solid tumors.
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Ruben Sebastian @rubensebas.bsky.social · 23/07/2025
Very encouraging news from Minoryx, one of my former #biotech portfolio companies Minoryx is one step closer to achieving approval for leriglitazone (NEZGLYAL) as the only pharmacological treatment for patients suffering from #cALD, a devastating #orphan disease www.minoryx.com/media/lerigl...
minoryx.com
Leriglitazone Marketing Authorization Application submitted for treatment of cerebral adrenoleukodystrophy has been validated by European Medicines Agency
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Ruben Sebastian @rubensebas.bsky.social · 22/07/2025
Sanofi to acquire Vicebio for $1.15 billion upfront to expand #respiratory vaccines pipeline Vicebio is a London-based #biotech with an early clinical-stage non-mRNA combination #vaccine candidate for respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) www.sanofi.com/en/media-roo...
sanofi.com
Press Release: Sanofi to acquire Vicebio, expanding respiratory vaccines pipeline
<p>Sanofi to acquire Vicebio, expanding respiratory vaccines pipeline Paris, July 22, 2025. Sanofi today announces it has entered into an agreement to acquire Vicebio Ltd (“Vicebio”), a privately held...
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