Reposted by Fabian Januszewski
Klimaforscher Prof. Anders Levermann vom @pik-potsdam.bsky.social El Niño: "Wenn wir sagen "wir wissen was nicht" und die Leute denken dann, das es dann auch vielleicht nicht passiert. Nein, es wird was passieren. Wir wissen nur nicht, was passieren wird. Und das ist das Problem."
![Fig 1.
Generation and validation of XBB.1.5+ mutant and virus revertant panel.
(A) Amino acid mutations present in the RBD of immune evasive SARS-CoV-2 variants Delta, BA.1, XBB.1.5, BQ.1.1 and BA.2.75, and RBD mutations present in engineered XBB.1.5+. (B) Comparison of serum neutralization ID50s against D614G, XBB.1.5 and XBB.1.5+ pseudotyped virus. Sera are collected from individuals who had had 3 doses of BNT162b2 mRNA vaccine and a BTI (Kruskal-Wallis multiple comparison test, *P < 0.0332, **P < 0.0021, ***P < 0.0002, and ****P < 0.0001). Error bars indicate geometric mean (red) ± standard deviation (s.d.) (black). (C) Surface representation of the WT Spike RBD (pdb: 6XM0) with amino acids reverted back to WT indicated by coloured surface. Mutations shared in one revertant are coloured the same. A full list of mutations can be found in S2 Table. (D) Heatmap showing fold rescue of neutralisation for reverted viruses compared to XBB.1.5+ for a panel SARS-CoV-2 mAbs isolated from convalescent and/or vaccinated donors [2,3,23] as well as therapeutic mAbs Sotrovimab, REGN10933 and REGN10987. mAbs were previously clustered using a competition binding ELISA into three RBD-specific competition groups [2,3,23].](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:zxxec4ic2lwsyf3vlaci7ub2/bafkreiftd5jajggt4ddhcclngazsoblf6k7vc3eyh5hlvhv43cmiuvjkrm)