iiinova — where your digital self keeps evolving

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uniQure reports that after 4 years, people given high-dose AMT-130 continue to show signs of slower HD progression, providing hope for their recent regulatory submission. But the new analyses are nuanced. We unpack the hopeful but complex results in this article → en.hdbuzz.net/amt-130-at-f...

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BCCHR ResDev (DM) @resdevbcch.bsky.social · 24/09/2026

‼️ attention Canadian health researchers ‼️ #CIHR has posted the Project Grants Discussion Paper and a related *survey* cihr-irsc.gc.ca/e/54821.html Please please participate 🙏

photo of the “help shape the future of the project grant program” announcement by CIHR. TEXT is accessible in the hyperlink in this post.

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Graham Dellaire @docdellaire.bsky.social · 25/09/2026

Double jeopardy grant review is a thing. On re-review of a grant at CIHR the success rate goes up when you have more reviewers re-reviewing the sequential resubmission. It rises to 59% success rate if all 3 reviewers re-review a grant vs 21% with no common reviewers. Let that sink in … 🤔

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HDBuzz @hdbuzzfeed.bsky.social · 24/09/2026

The CAG repeat that causes Huntington’s disease (HD) has a tendency to grow with age. New research on over 900,000 people uncovers parallel patterns and finds CAG growth can happen in many other parts of the genome. #hdresearch Read the full article → en.hdbuzz.net/studying-stu...

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Jim Woodgett @jwoodgett.bsky.social · 23/09/2026

There’s a concerted campaign to undermine EDI in Canada. The evidence behind EDI policies reducing excellence are based on abysmal, flawed evidence. Look at who feels threatened by equity, diversity and inclusion. They’re the least diverse, least equitable and most exclusive people. Just no.

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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 21/09/2026

GAPDH is tethered to axonal transport vesicles by S-acylation www.biorxiv.org/content/10.64898/20…

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André Picard @picardonhealth @picardonhealth.bsky.social · 17/09/2026

Sanofi inaugurates $925-million Toronto facility that will produce seasonal flu vaccines for Canadians. Site is also designed to provide new capacity for vaccine production in event of another pandemic, by @hannay.bsky.social www.theglobeandmail.com/business/eco... via @theglobeandmail.com

theglobeandmail.com

Sanofi inaugurates Toronto facility that will produce seasonal flu vaccines for Canadians

French pharmaceutical maker’s site is also designed to provide new capacity for vaccine production in event of another pandemic

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DMartin @drddom.bsky.social · 16/09/2026

But seriously, when did this happen & why? Also, am I the only one who cares? It's hard to teach students that latin words have to be italicized if they're not seeing it in the papers they read.

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HDBuzz @hdbuzzfeed.bsky.social · 16/09/2026

Skyhawk Therapeutics shared data for SKY-0515, an experimental once-daily pill that targets both huntingtin and somatic instability, making it a possible “two-for-one” drug to treat HD. Read more about this exciting news on HDBuzz → en.hdbuzz.net/encouraging-...

Graphic of a megaphone with the words, "Encouraging news from Skyhawk Therapeutics!" above.

Picture of pills from a pill bottle with words on text boxes: "A potential 2-for-1 approach to treat HD is safe and shows potential! SKY-0515 is an experimental once-daily pill that aims to lower huntingtin AND target somatic instability."

Close up photo of a doctor checking lab results. Words in text boxes read, "In the Phase 1/2 study, SKY0515 did just that, and showed positive changes in tests of movement & thinking." But will that add up to a treatment that slows HD?"

Text box: "Skyhawk's Phase 2/3 study, FALCON-HD, will tell us whether the Phase 1/2 study's promising signs hold up in a larger, placebo-controlled trial."

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Andrew Iwaniuk @evoneuro.bsky.social · 16/09/2026

For the benefit of followers who have complained to me about how I’m wrong and Canada values science and advanced education, a graph that illustrates my point #Canada

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Lesley MacNeil @steeltownworms.bsky.social · 16/09/2026

It's 2026 and a bunch of dudes just published something called the "Equity-excellence trade-off". Their central hypothesis is that CRC should not have introduced quotas that force universities to nominate women and minorities. They want to go back to a time when chairs were 80% men and mostly white.

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DMartin @drddom.bsky.social · 16/09/2026

Can someone tell me when journals stopped italicizing latin terms like in vitro or in vivo?

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Sergey Ovchinnikov @sokrypton.org · 14/09/2026

Finally a more intuitaive way to learn pLDDT/pAE? 😎 sokrypton.github.io/protein_figh... (Character idea from @hannes-stark.bsky.social & Alex Waldherr)

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DMartin @drddom.bsky.social · 13/09/2026

Was running through Victoria Park today listening to the audio book for Black House by @stephenking.bsky.social & Peter Straub. This plaque is very fitting & kinda creepy. IYKYK. 'Gorg! Ty! Abbalah!'

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DMartin @drddom.bsky.social · 11/09/2026

We just a little closer to understanding the complexity that is ZDHHC13. Check out this work from @drssfs.bsky.social with implications in Huntington Disease. ZDHHC13 Is a Catalytically Deficient Protein S-Acyltransferase That Functions via a Noncanonical Mechanism tinyurl.com/3yp958up

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Merja Joensuu @joensuulab.bsky.social · 11/05/2026

The latest publication from the lab is now out in @natureportfolio.nature.com. We show that pharmacological inhibition of NMT1 perturbs respiratory virus infectivity due to Golgi-bypassing egress, compromising spike maturation and incorporation. www.nature.com/articles/s41... 🦠🧫🔬

nature.com

Inhibition of host N-myristoylation compromises the infectivity of SARS-CoV-2 due to Golgi-bypassing egress - Nature Communications

Here the authors show that inhibition of host N-myristoyltransferase by IMP1088 reduces SARS-CoV-2, VSV and RSV infection across lung and nasal cells, through a Golgi-bypassing virion egress that disr...

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Merja Joensuu @joensuulab.bsky.social · 11/05/2026

NMT1 inhibition blocks N-myristoylation of newly synthesized proteins - an important fatty acid function - disturbing ER to Golgi trafficking and activating an unconventional secretory pathway from ER to plasma membrane. Wild. Congratulations to all authors! 🎉 #antiviral #SARSCoV2 #RSV #VSV

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Elle Cordova @ellecordova.bsky.social · 08/09/2026

I am the very model of a modern day typographer A font take on the tune “Modern Major General” by Gilbert & Sullivan #typography #fonts #graphicdesign

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DMartin @drddom.bsky.social · 04/09/2026

TFW when labs reach out for help to do basically the things you've tried to get funded 8 times by CIHR, but can't convince reviewers is important. At least someone's doing the research...

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DMartin @drddom.bsky.social · 02/09/2026

This is wild. Not sure I can remember a time where Canadians were so united. 'The very large majority (78%) believe the federal government made the right decision to reject the proposals of the Trump Administration and end the negotiations.' bruce728.substack.com/p/liberals-l...

bruce728.substack.com

Liberals lead 49%-29%. Approval of Carney government climbs to new high.

Canadian voters are galvanized by Trump’s attacks and aligned with Carney’s approach.

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#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 01/09/2026

Excessive cholesterol accumulation in microglia increases neuronal synaptic vulnerability to amyloid-beta #NeuroDegeneration 🧪🧠 www.biorxiv.org/content/10.64898/20…

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Sarah McAnulty, Ph.D. @sarahmackattack.bsky.social · 01/09/2026

I feel like I’m going to throw up

Screen shot of an Instagram post that says the academy of natural sciences is closing its museum after nearly two centuries

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DMartin @drddom.bsky.social · 01/09/2026

OK #Neuroscience friends. I'm teaching a grad course on New Topics in Neuroscience. What are you reading these days that excites you? Students for this class have backgrounds in theoretical Neuro, math, engineering, biochem, physiology, pharmacy, & more.

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Peter Pelka @peterpelka.bsky.social · 01/09/2026

My department and the University of Manitoba is hiring a structural virologist/vaccinologist for a tenure-track position at assistant or associate level, if you know of someone or are interested the details can be found in this job ad: jobs.sciencecareers.org/job/679829/a...

jobs.sciencecareers.org

Assistant or Associate Professor in Vaccinology or Biologics - Winnipeg (Region), Manitoba job with The University of Manitoba Department of Microbiology | 679829

The candidate will be expert in applied vaccinology or therapeutic biologics related to human/zoonotic viral pathogens.

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DMartin @drddom.bsky.social · 29/08/2026

2 grant rejections 1 manuscript - revise 1 massive manuscript submitted After the 2 grants, it took me a full day to be able to read the paper revisions. #academiclife

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DMartin @drddom.bsky.social · 29/08/2026

What a rollercoaster of a Friday. Got reviews back for a paper. Revisions! Not outright rejected! I'll take it.

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DMartin @drddom.bsky.social · 28/08/2026

Another Friday and another 2 grants rejected. This is definitely a big grant rejection year. But a big publication/submission year. Hope that means some grants next year. If not.....

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BCCHR ResDev (DM) @resdevbcch.bsky.social · 28/08/2026

dear Canadian grant reviewers and international reviewers of Canadian grants: NOPE NOPE NOPE federal policy prohibits use of AI for grant review. **please respect the privacy / confidentiality of your peers** thank you!

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DMartin @drddom.bsky.social · 28/08/2026

It's currently 16.2C in my office. It's 20C outside. There is a person who can fix this in minutes, but they're not allowed. Submitted a work order on Monday. Was confirmed on Tuesday. Nothing has been done. We're literally using waterbaths to bring things to RT. #Academia

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DMartin @drddom.bsky.social · 27/08/2026

Reposting using a Canadian News Site :-P Someone is wee bit upset. www.cbc.ca/news/world/t...

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Stacey Ogden 🦔 @labogden.bsky.social · 27/08/2026

Reading the old* literature from your field is ALWAYS a good idea 🧪 *Papers from before you started your research project. *Papers you haven't read since they came out ~years~ ago. *Papers from pioneers in your field.

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DMartin @drddom.bsky.social · 27/08/2026

They sorted the dogs into Hogwarts Houses last week. Ruby was a Hufflepuff. No surprise. She's afraid of everything, but very smart (and cute). (No funds went to She who must not be named)

A sad looking, but incredibly cute, American bully dog is getting ready to pose with the sorting hat from Harry Potter. There's a small pen at in front of her saying Hufflepuff. In the back drop is a poster of Hogwarts.

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DMartin @drddom.bsky.social · 27/08/2026

Ugh. It's 16-17C in my lab and the one guy who can fix it isn't allowed to anymore unless we submit a work order. And it took 24 hours just for the work order to be initiated. We can't do any experiments (maybe a ligation) at this temp.

static.klipy.com

Jon Snow Freezing Cold in the Snow

ALT: Jon Snow Freezing Cold in the Snow

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Reese Richardson @reeserichardson.bsky.social · 25/08/2026

A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵

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Government of British Columbia @governmentofbc.bsky.social · 24/08/2026

Watch Dr. Kopstick's story and hear why he chose to build his future in BC. Know a health-care worker in the US? Share this story, or tag them in the comments, and let them know BC's hiring.

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DMartin @drddom.bsky.social · 25/08/2026

Anyone else feel like someone watched Canadian Bacon & Idiocracy and asked how do we make these two movies happen?

static.klipy.com

John Candy Smile

ALT: John Candy Smile

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Max Fawcett @maxfawcett.bsky.social · 23/08/2026

Paging Jamil Jivani and Danielle Smith

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DMartin @drddom.bsky.social · 23/08/2026

If it found me at all over the past 5 days, this is how your email found me.

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Sarah Yip @yiplab.bsky.social · 19/08/2026

Looking for a postdoc in addiction and neuroimaging!! Check out medicine.yale.edu/biomedical-i... Message me directly if you are interested in hearing about opportunities to apply to work with the YIP lab :)

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Sarah Whorley, Ph.D. 🦬⚔️ @dralgaegirl.bsky.social · 19/08/2026

Tenure Track job alert! We're hiring someone to teach Microbiology and Genetics! Know someone on the job market? Must have a PhD. Position is mostly teaching (65%) but research expected. Send them my way! Will have official ad details soon 🧪🦠🧬

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DMartin @drddom.bsky.social · 19/08/2026

The infrastructure at many Canadian institutions is frankly embarrassing. I can't imagine what the total cost in time & lost research because university admin & government won't invest in the things we need.

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DMartin @drddom.bsky.social · 17/08/2026

To make it worse they ran out of almost all meals. @aircanada.bsky.social Almost no options by the time they got to us and we weren't even halfway down the plane.

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DMartin @drddom.bsky.social · 17/08/2026

Finally taking vacation & heading to BC. But we've been sitting on the tarmac for almost 2 hours. Somehow we're too heavy to land in Kelowna due to the fires. Not sure how we're going to get lighter unless we're just burning fuel.

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HDBuzz @hdbuzzfeed.bsky.social · 14/08/2026

Day 3 of #HD2026 put the huntingtin protein (HTT) under the microscope. Researchers shared new insights into HTT1a, next-generation HTT-lowering approaches, somatic expansion, brain circuitry, and why boosting healthy HTT might help. Read our roundup here: en.hdbuzz.net/hd2026-milto...

The final day of HD2026 put the huntingtin protein (HTT) under the microscope.

Researchers shared:

- new insights into HTT1a
- next-generation HTT-lowering approaches
- why boosting healthy HTT might help

And lots more!

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HDBuzz @hdbuzzfeed.bsky.social · 13/08/2026

Welcome to Day 3 of the #HD2026 Milton Wexler Biennial Symposium, where HDBuzz is reporting live for this final day of talks. Morning sessions will focus on huntingtin (HTT), including a fragment of the expanded HTT protein that seems to be extra harmful.

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Cailyn Creative @cailyncreative.bsky.social · 24/03/2026

My dream is to improve scientific literacy and reduce barriers to scientific knowledge. I love my fellow scientists and community; however, there are critical issues with knowledge accessibility that impact how effectively we are able to communicate cutting-edge research to lay audiences.

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