journals.asm.org
ARGLU1 is a negative regulator of the adenoviral replicative cycle | Journal of Virology
This study uncovers a novel antiviral role for ARGLU1, known for its involvement in splicing, transcriptional regulation, and DNA damage repair. Our study demonstrates that ARGLU1 functions as a viral restriction factor by reducing virus growth through the inhibition of viral gene expression and enhanced DNA damage response, leading to reduced viral growth. These findings not only highlight an important role for ARGLU1 in host antiviral mechanisms but also emphasize the utility of adenovirus as a tool to uncover critical cellular pathways.