iiinova — where your digital self keeps evolving

David Darrow @drdaviddarrow.bsky.social · 24/09/2026

Help us shape the future of neuromodulation for SCI. We're hiring a postdoc at Hennepin Healthcare/HHRI to work on epidural stimulation in chronic motor-complete SCI. Human SCI research experience is preferred. Lab: restorativeneurotraumalab.org Apply: hhri.applicantpro.com/jobs/4208800

restorativeneurotraumalab.org

Restorative Neurotrauma Lab

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David Darrow @drdaviddarrow.bsky.social · 17/08/2026

Some mail you never forget opening. Thank you NIH, NINDS + the HEAL Initiative for funding SENAP: a trial for central neuropathic pain: pain generated by the brain itself after stroke, MS, or spinal cord injury. We finally know where it lives. Now we get to go there. 🧠

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David Darrow @drdaviddarrow.bsky.social · 14/08/2026

Pain prevention may start when the nerve is cut. In 32 tumor amputations, RPNI was associated with less 12-week pain (25% vs 68.8%) and no phantom limb pain (0% vs 43.8%). Lin, Chen, Zang, Wang & Li @pku1898.bsky.social. doi.org/10.1227/ons....

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David Darrow @drdaviddarrow.bsky.social · 10/08/2026

Could an SCS trial be more than a device screen: a reversible test of pain diagnosis and responsiveness? Failed trials/explants were associated with higher mortality; ongoing SCS was not. Could that phenotype someday inform procedures like fusion? doi.org/10.1227/neu....

doi.org

Mortality Outcomes After Spinal Cord Stimulation:... : Neurosurgery

BACKGROUND AND OBJECTIVES:Spinal cord stimulation (SCS) is an established but intricate therapy for neuropathic pain. Chronic pain is associated with...

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David Darrow @drdaviddarrow.bsky.social · 06/08/2026

After the recent navigation paper, a classic from Neurosurgery: in 1,216 patients with TN, pain-free survival after one RF rhizotomy was 57.7% at 5 years. The curve captures both durable benefit and the reality of recurrence. #trigeminalneuralgia doi.org/10.1097/0000...

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David Darrow @drdaviddarrow.bsky.social · 04/08/2026

Accessing the foramen ovale can be the hardest part of percutaneous TN rhizotomy. In 61 procedures, EM navigation reduced fluoroscopy from 7.0 to 1.3 minutes, with no detected difference in pain outcomes. Great work by Shervin Rahimpour and colleagues. doi.org/10.1227/ons....

doi.org

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David Darrow @drdaviddarrow.bsky.social · 26/06/2026

New TN guideline episode is live. Payal Soni, MD joins @SBenHaimMD, @vishadsukul and me to discuss headache neurology, facial pain mimics, red flags, imaging, recurrence, and outcomes. youtu.be/rxOeBJapV5k #TrigeminalNeuralgia #FacialPain

youtu.be

Trigeminal Neuralgia Guidelines: Headache Neurology & AHS Perspective | Payal Soni

YouTube video by drdaviddarrow

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David Darrow @drdaviddarrow.bsky.social · 12/06/2026

New TN guideline stakeholder episode: Anna Williams, Melissa Baumbick, Marshall Holland, MD, and Donald Nixdorf, DDS, MS discuss patient priorities, treatment burden, recurrence, and quality of life. www.youtube.com/watch?v=Ou4u... #TrigeminalNeuralgia #FacialPain

youtube.com

Trigeminal Neuralgia Guidelines: Facial Pain Association Stakeholder Discussion

YouTube video by drdaviddarrow

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David Darrow @drdaviddarrow.bsky.social · 18/05/2026

New trigeminal neuralgia guideline episode: Vishad Sukul and I speak with neuroradiologist Ajay Malhotra about MRI protocols, neurovascular compression, secondary causes, recurrence, and imaging standardization. youtu.be/TyFj0hpSTv0 @theasnr.bsky.social #TrigeminalNeuralgia #MRI

youtu.be

Surgical Trigeminal guidelines with Ajay Malhotra from ASNR

YouTube video by drdaviddarrow

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David Darrow @drdaviddarrow.bsky.social · 18/05/2026

Brain disorders are network disorders but the map we build depends on the metric we choose. Our new open-access paper validates effective connectivity metrics for detecting delayed, directed coupling in simulated brain networks. Metrics matter. doi.org/10.1088/1741...

doi.org

Metric validation for detection of delayed and directed coupling

Metric validation for detection of delayed and directed coupling, Dembny, Kate, Farooqi, Hafsa, Herman, Alexander B, Netoff, Theoden I, Darrow, David P

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David Darrow @drdaviddarrow.bsky.social · 27/04/2026

Nice paper on stereotactic radiosurgery for refractory cluster headache. The time course is mechanistically interesting: improvement, then recurrence in some patients. Pain circuits are normal physiologic circuits. Recurrence may reflect network adaptation or healing/recovery after radiation.

doi.org

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David Darrow @drdaviddarrow.bsky.social · 26/04/2026

Our first stakeholder conversation for the AANS/CNS Joint Section on Pain trigeminal neuralgia guideline effort is live. Dr. Michael Staudt and I spoke with Dr. Gary Klasser about orofacial pain, TN vs neuropathy, imaging, dental misdiagnosis, and patient-centered care. youtu.be/reYNipKY3WM

youtu.be

Trigeminal Neuralgia, Orofacial Pain & Surgical Guidelines | Gary Klasser

YouTube video by drdaviddarrow

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David Darrow @drdaviddarrow.bsky.social · 23/02/2026

New case report published on trigeminal ganglion stimulation for refractory anesthesia dolorosa. Rather than a binary “complete anesthesia + pain,” clinical nuance suggests a spectrum of deafferentation.

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David Darrow @drdaviddarrow.bsky.social · 17/02/2026

Thank you to @u2fp.bsky.social for the invitation to talk about the future of #neuromodulation for #spinalcordinjury So many good speakers and great ideas

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Reposted by David Darrow

BD² @bipolardiscoveries.org · 19/11/2025

🧪 Research Spotlight: Ziad Nahas, MD, MSCR, is studying how brain networks regulate mood in #BipolarDisorder & how instability drives shifts between depression & mania with PACE 👉 Goal: Test if targeting networks can improve mood & reveal mechanisms behind switches. 🔗 bit.ly/4gTbBwU

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David Darrow @drdaviddarrow.bsky.social · 29/10/2025

We are excited to be a part of this community to further efforts to understand and treat #bipolardisorder where we hope to bring biological insight back to psychiatry @umn-tc-aaup.bsky.social

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David Darrow @drdaviddarrow.bsky.social · 10/08/2025

This is the future. The reality of biological #psychiatry. We listen to the patient, create a personalized map of their brain, use algorithms to disrupt stuck networks, and adapt the stimulation over time while continuing our quest to understand those networks.

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Reposted by David Darrow

Damien Fair @drdamienfair.bsky.social · 26/06/2025

Alert!!!! “An Action Networks Model for Pain” We propose a new model for chronic pain — and highlight two functionally connected cortical networks that could revolutionize how we treat it. 👉 thread below 🧵 osf.io/preprints/ps...

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David Darrow @drdaviddarrow.bsky.social · 22/03/2025

We bid farewell to our amazing postdoc @xinyuanyan.bsky.social and congratulations on her new position with @benhayden.bsky.social @bcmhouston.bsky.social

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David Darrow @drdaviddarrow.bsky.social · 22/01/2025

With a thousand people essentially choosing between slot machines, we were able to figure out that anxiety traits and apathy traits provide counterbalance pushing us to either search for better options or stick with what is working, guiding our decisions #universityofminnesota

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