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Doudna Lab

@doudna-lab.bsky.social

6.8K followers 273 following 46 posts

News from Jennifer Doudna's lab at UC Berkeley, Innovative Genomics Institute. Tweets from lab members and not Jennifer Doudna unless signed JD. Tweets represent personal views only. doudnalab.org

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Doudna Lab @doudna-lab.bsky.social · 16/07/2026

🧵6/6 And we resolved a previously unobserved TAM-bound state providing further mechanistic insights!

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Doudna Lab @doudna-lab.bsky.social · 16/07/2026

🧵5/6 We solved the first experimental structures of an AI-designed RNA-guided nuclease, which revealed new protein-nucleic acid contacts across conformational states.

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Doudna Lab @doudna-lab.bsky.social · 16/07/2026

🧵4/6 Some of our synthetic gene editors exceeded natural proteins in activity while being equally specific.

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Doudna Lab @doudna-lab.bsky.social · 16/07/2026

🧵3/6 We assessed activity using a high-throughput bacterial assay, followed by editing the human and plant genomes 🧫🌱

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Doudna Lab @doudna-lab.bsky.social · 16/07/2026

🧵2/6 By coupling inverse folding with protein and DNA/RNA evolutionary conservation, we achieved a high design success rate ⚙️

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Doudna Lab @doudna-lab.bsky.social · 12/05/2026

We programmed CRISPR-Cas12a2 to recognize cancer mutations, especially in TP53, and selectively kill mutant cells through transcript-activated chromatin shredding.

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Doudna Lab @doudna-lab.bsky.social · 12/05/2026

We programmed CRISPR-Cas12a2 to recognize cancer mutations, especially in TP53, and selectively kill mutant cells through transcript-activated chromatin shredding.

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Doudna Lab @doudna-lab.bsky.social · 09/12/2025

🧵4/4 We solved the first experimental structure of an AI-designed RNA-guided nuclease, which revealed new protein-nucleic acid contacts across conformational states. 🔗 See our preprint: www.biorxiv.org/content/10.6...

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Doudna Lab @doudna-lab.bsky.social · 09/12/2025

🧵3/4 We assessed activity using a high-throughput bacterial assay, followed by editing the human and plant genomes 🧫🌱

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Doudna Lab @doudna-lab.bsky.social · 09/12/2025

🧵2/4 By coupling inverse folding with evolutionary information, we generated highly active and diverse variants with a high design success rate ⚙️

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Doudna Lab @doudna-lab.bsky.social · 09/12/2025

✨New preprint! 🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al! Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬 🔗👇

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Doudna Lab @doudna-lab.bsky.social · 09/12/2025

🧵3/4 We assessed activity using a high-throughput bacterial assay, followed by editing the human and plant genomes! 🧫🌱

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Doudna Lab @doudna-lab.bsky.social · 09/12/2025

🧵2/4 By coupling inverse folding with evolutionary information, we generated highly active and diverse variants with a high design success rate ⚙️

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Doudna Lab @doudna-lab.bsky.social · 02/10/2025

"Jane Goodall showed us what a life in science could look like: rigorous discovery paired with fierce advocacy for what you study. She gave the world six decades of groundbreaking research on chimpanzees and their habitats, then turned that knowledge into a global movement for conservation." (1/2)

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