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Alex DiFeliceantonio

@difeliceantonio.bsky.social
682 followers 143 following 302 posts

Assoc. Prof. at Virginia Tech. My lab (DONNUT) studies brain/metabolism interactions in food reward. Scifi reader. Plant killer. She/her Lab Website: fbri.vtc.vt.edu/research/labs/difel…

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Alex DiFeliceantonio @difeliceantonio.bsky.social · 06/10/2026
I don't think you are being genuine, here. I gave you the nutrition information. You can verify it. I don't think this is productive. Again, my only ask is to not misrepresent what we did.
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 06/10/2026
Again, you have your own thoughts on how this study should have been run. You are welcome to them. You can run your own. I only asked that you did not misrepresent what we did. I pointed out calling it a "glass of water" was a misrepresentation.
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 06/10/2026
Again, the framing of the study is identical nutrition information. So, here is the nutrition information. It is similar. You just said the energy density didn't match and we had to give participants a "glass of water." This is not true.
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 06/10/2026
But it was your favorite detail...
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 06/10/2026
Harldy "kloodgy." You've made your viewpoint on UPF clear, and that's fine. But don't misrepresent what we did.
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 06/10/2026
Becuase that was not our hypothesis. We wanted a broad range of foods so you could generalize across the category, not so you could make an inference about bread or peanut butter alone. We can all suggest a million studies but time and resources are limited.
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 06/10/2026
12mls of water is 12grams. The total meal weight was 156 grams. So, 156-12=144. 304/144 (energy density is kcals/g)=2.1. The MPF ED was 1.9. So, is your argumet a 0.2 difference in energy density is responsible for all of the effects?
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 06/10/2026
In the limitations of the paper we note we need additional follow up studies. But, we set out to test if foods classied as UPF under the Nova system with near identical nutrition information as non-UPF evoked a similar metabolic response. And we tested and reported on that outcome.
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 06/10/2026
It was 12mls, which is less than a shot. Barely half way up the medicine cup.
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 05/10/2026
was just texted if anyone did a wellness check or if they could hear screaming coming fromt he general area of Cambridge.
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 05/10/2026
@naturemetabolism.bsky.social did a Research Breifing: www.nature.com/articles/s42... with a summary of Zach and I's planning of this project: “This will be a lot of work for a null result, Alex”
nature.com
Ultraprocessed foods evoke distinct metabolic and neural responses - Nature Metabolism
Ultraprocessed foods have been linked with various poor health outcomes. In our study, we characterize acute metabolic responses to these foods and investigate how our brains might encode food value, ...
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 05/10/2026
Out today in @naturemetabolism.bsky.social ! www.nature.com/articles/s42... Excited to see this one out. I’ve been yapping about it forever! @fralinbiomed.bsky.social
nature.com
Metabolic and neural responses to ultraprocessed foods: a randomized, controlled, crossover study - Nature Metabolism
In a randomized study in 57 healthy-weight adults, researchers compared nutritionally matched ultraprocessed and non-ultraprocessed meals and found that ultraprocessed foods elicited greater insulin a...
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 02/10/2026
When the scanner is dead, though, you can make your lab pose for rediculous photos.
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 02/10/2026
We tried to send the Trio off in style -- but it was kind of anti-climactic.
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 28/09/2026
ajph.aphapublications.org/doi/10.2105/... Food industry funded studies are at least twice as likely to defend or promote UPF than those without industry funding.
ajph.aphapublications.org
AJPH
American Journal of Public Health (AJPH) from the American Public Health Association (APHA)
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 17/08/2026
My graduate student and my dean have the same first name. Who wants to guess which one outlook puts at the top everytime I go to send a calendar invite or email?
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 07/08/2026
Come see Mario and Emma today!! @ssibsociety.bsky.social @fralinbiomed.bsky.social Flavor nutrient conditioning and UPF! What more could you want. #ssib2026
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 05/08/2026
It’s here! Come see what the lab is up to at #SSIB2026
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 30/07/2026
Getting ready for @ssibsociety.bsky.social next week!! So excited to see everyone. If you want to check out what the lab has been up to, here are all of our presentations/posters.
Thursday Afternoon — 6th
4:30–5:30 PM
Poster Session 2, Exhibits & Coffee Break
Poster #	Presentation	Presenter
134	Ultra-processed foods elicit distinct metabolic and neural responses despite nutritional matching	Zach
160	Effects of non-nutritive sweetener consumption on blood metabolic response	Han
Friday Morning — 7th
9:00–10:00 AM
Poster Session 3, Exhibits & Coffee Break
Poster #	Presentation	Presenter
207	Considering flavor-flavor learning in flavor-nutrient learning paradigms	Mario
10:00–11:30 AM
Symposium 2: Boldly Going: The Next Generation in Testing Neuromodulators
Time	Presentation	Presenter
10:00 AM	Monoamine release dynamics in the human amygdala dissociate components of food reward	Matt
10:00–11:30 AM
Oral Session 4: K-POP Diet Hunters: Diet Quality & Health
Time	Presentation	Presenter
10:45 AM	Effects of controlled diets high in and free of ultraprocessed food on the brain of emerging adults	Emma
Saturday Afternoon — 8th
2:00–3:00 PM
Poster Session 5, Exhibits & Coffee Break
Poster #	Presentation	Presenter
314	Comparison of food NOVA scores with and without contextual data	Christy
3:00–4:30 PM
Oral Session 7: CH-CH-CH-CH-CHANGES: Interventions & Therapeutics
 
Time	Presentation	Presenter Mary Elizabeth
4:15 PM	Brain response is influenced by varying rates of metabolic response to carbohydrate consumption in a flavor-nutrient conditioning paradigm
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 03/07/2026
I had to get a nerve block yesterday for an intractable migraine (8 days). Easily top 5 weirdest experiences of my life. But also medicine is amazing and I almost feel like a human today.
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 29/06/2026
Boys becoming men, men becoming WOLVES. media.giphy.com/media/v1.Y2l...
giphy.com
30 Rock GIF - Find & Share on GIPHY
GIPHY image by GIPHY
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 04/06/2026
It also lays the gound work to create data driven methods to predict addictiveness ratings in new foods completely out of sample. This work was a collaboration between UofM, KU, ORI, and VT. Big thanks to everyone involved, they are a great group to work with. 7/7
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 04/06/2026
It gives us good data for something we had more spotty data on before, but that was kind of intuitive, that not all foods have equal addictive potential. So, when we are discussing potential risks and harms, we can narrow our scope to foods with certain nutrient profiles. 6/7
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 04/06/2026
For the NDSR variables we see glycemic load, carbs, and energy density. Not a big surprise for anyone, I know. So what does this mean? 5/7
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 04/06/2026
We used two inputs, the nutrients on the back of your nutrition label and all nutirent variables in the output for NDSR. The models gave similar results, here is the one from the back of the label. Carbohydrates, fat, energy density were all top factors. 4/7
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 04/06/2026
We found some patterns in nutrients across the rated addictiveness tertiles, but food is complicated and nutrients can interact in different way. So, we turned to random forest modeling. 3/7
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 04/06/2026
We recruited 1664 adults to rate a sample of 297 commonly consumed foods using a modified version of the Yale Food Addiction Scale to assess the addictive potential of each food. We found, unsuprisingly, that not all foods have the same addictive potential. 2/7
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 04/06/2026
New paper out in @amjpublichealth.bsky.social! We used machine learning to identify nutritional charecteristics of foods with addictive potential as rated from a national sample. @fralinbiomed.bsky.social This was a big collaborative effort! 1/7 🧪 ajph.aphapublications.org/doi/suppl/10...
ajph.aphapublications.org
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 03/06/2026
Being in science is especially wierd right now, it feels hard to be excited about milestones. But, I'm still trying to celebrate important things when they happen. Matt and I got tenure! news.vt.edu/articles/202...
news.vt.edu
Board of Visitors approves 2026 promotions, tenure, and continued appointments
The board approved the following promotions, tenure, and continued appointments.
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 29/05/2026
Let them eat golden horses
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 23/05/2026
Still tired but mentally back here.
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 19/05/2026
Right? But also in true @tkingfisher.com fashion the monster is kind of an OK guy? And the middle aged heroine just convinces everyone to be reasonable by being rather reasonable. Anyway just finished it and loved it.
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 17/05/2026
I went to school here 20 years ago… Made it to the Dopamine Society Meeting in Seville!! I am so very tired.
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 14/05/2026
POV: your graduate student in 6’6” and the little box isn’t quite enough lift.
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 14/05/2026
Congratulations to the lab’s newest PhDs! Emma Leslie and Zach Hutelin!! @fralinbiomed.bsky.social
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 13/05/2026
Congrats!! Excited to read it!
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 11/05/2026
I need to hurry up and finish my current book!
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 11/05/2026
If you have more computation interests and would like to work on a collaborative project with Read Montague and Matt Howe using data from patients with implanted electrodes. Take a look at this application: jobs.apply.vt.edu/jobs/postdoc... Email or DM me if you have questions!
jobs.apply.vt.edu
Postdoctoral Associate - Roanoke, Virginia, United States
Job Description The Montague, DiFeliceantonio, and Howe Laboratories at the Fralin Biomedical Research Institute at Virginia Tech are seeking a motivated and creative Postdoctoral Associate. The lab...
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 11/05/2026
We have two post-doctoral fellow positions posted for the lab and for a collaborative project! If you are interested in understanding how diet affects the brain and how that influences eating behavior, please apply here: jobs.apply.vt.edu/jobs/postdoc...
jobs.apply.vt.edu
Postdoctoral Associate - Roanoke, Virginia, United States
Job Description The DiFeliceantonio (DONNUT) Lab at the Fralin Biomedical Research Institute at Virginia Tech is seeking an enthusiastic Postdoctoral Associate. Led by Dr. DiFeliceantonio, the lab a...
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 08/05/2026
The article on Mary Elizabeth's K01 is in the VT News! I'm excited for her to do this work and take the nex step in her career! She's also a triple hokie @virginiatech.bsky.social !! news.vt.edu/articles/202...
news.vt.edu
Grant backs early-career study on metabolism and food choices
The award from the National Institutes of Health will support Mary Elizabeth Baugh ’09, M.S. ’13, Ph.D. ’18 and her research into better understanding how changes in brain activity translate into how ...
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 05/05/2026
He did it with glee while posing with a chain saw. Hundreds of thousands of children dead.
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Reposted by Alex DiFeliceantonio
Anjali Dayal @anjalikdayal.bsky.social · 05/05/2026
“The dismantling of USAID, according to models from Boston University epidemiologist Brooke Nichols, “has already caused the deaths of six hundred thousand people, two-thirds of them children,” Gawande wrote.” hsph.harvard.edu/news/usaid-s...
hsph.harvard.edu
USAID shutdown has led to hundreds of thousands of deaths | Harvard T.H. Chan School of Public Health
The Trump administration’s decision to shut down the U.S. Agency for International Development (USAID) has resulted in hundreds of thousands of deaths from infectious diseases and malnutrition, accord...
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 02/05/2026
Am I being sub skeeted
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 02/05/2026
More follow up is obviously needed. Controlled feeding is HARD. This study would not be possible without @davybrenda.bsky.social. @ermaderm.bsky.social led the brain portion of this effort and just defended her PhD!
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 02/05/2026
But we did see effects in younger people and as we are learning what aspects of the food could be risk factors we can’t ignore what PEOPLE might be most vulnerable to health effects, and it seems like younger people could be especially susceptible. /7
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 02/05/2026
All diets were nutritionally matched and eucaloric. Again we don’t see effects in the overall group, so as we’re thinking about what are aspects of UPFs that could lead to brain and behavior changes, ad libitum access could be an important factor. 6/
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 02/05/2026
@borglandlab.bsky.social has really cool data showing both short and long term effects of diet interventions in the OFC. Obviously different measures but it’s cool to see patterns in rodents repeated in humans. 5/ pubmed.ncbi.nlm.nih.gov/37793910/
pubmed.ncbi.nlm.nih.gov
Short- and Long-Term High-Fat Diet Exposure Differentially Alters Phasic and Tonic GABAergic Signaling onto Lateral Orbitofrontal Pyramidal Neurons - PubMed
The chronic consumption of caloric dense high-fat foods is a major contributor to increased body weight, obesity, and other chronic health conditions. The orbitofrontal cortex (OFC) is critical in gui...
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 02/05/2026
We also know what people were eating before they entered the study. UPF in their habitual diet also was associated with OFC response regardless of age or previous diet condition. 4/
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 02/05/2026
The relationship is of course more linear than a simple cut off: 3/
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Alex DiFeliceantonio @difeliceantonio.bsky.social · 02/05/2026
After controlled feeding, no voxels survive a time by diet interaction, but a diet by time by age reveals a different story. Activity in the OFC to the UPF milkshake is altered by a two week UPF diet interaction younger people but not our older cohort. 2/
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