In adipocytes, hormone-sensitive lipase (HSL) plays a key role in hydrolyzing triacylglycerols that are stored in lipid droplets. Contrary to the expe…

Nature Reviews Endocrinology, Published online: 07 August 2025; doi:10.1038/s41574-025-01163-3Adipose tissue thermogenesis is not proportional to temperature

Dumont et al. reveal that although heat generated by shivering muscles and by the heart increases based on the degree of cold exposure, heat-producing mechanisms present in adipose tissues like brown and white fat respond in an all-or-nothing fashion. In brown fat, the heat produced likely reflects its thermogenic capacity.

Despite many decades of research examining thermoregulatory responses under varying cold stresses in humans, very little is known about the variability in metabolic heat production and shivering activ...

The explosive growth in the study of human BAT has led over time to lively debates over central physiological concepts. This perspective discusses six areas of current disagreement and proposes experiments to achieve resolutions and move the field forward.

npj Metabolic Health and Disease - Human adipose depots’ diverse functions and dysregulations during cardiometabolic disease

Obesity is chronic disease and causal precursor to myriad other conditions, including type 2 diabetes. In an earlier analysis of the SURMOUNT-1 trial, tirzepatide was shown to provide substantial a...