Dufau, Recazens, et al. identified the neutral lipase HSL in the nucleus of adipocytes, where it modulates gene expression. The trafficking of HSL between the nucleus and the cytosol is under the cont...

Dufau, Recazens, et al. identified the neutral lipase HSL in the nucleus of adipocytes, where it modulates gene expression. The trafficking of HSL between the nucleus and the cytosol is under the control of TGF-β and catecholamine signaling. In vivo, the presence of nuclear HSL is crucial for adipose tissue development.

Toutes les personnes ayant perdu du poids, via des mesures hygiéno-diététiques, un traitement médical ou une chirurgie bariatrique, le savent que trop bien : elles risquent rapidement de reprendre du ...

In mouse and nonhuman primate models, treatment with selective, long-acting neurokinin 2 receptor agonists aids weight loss by suppressing appetite and increasing energy expenditure, as well as b...

Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to th...

This study shows that intracellular lipolysis in brown adipose tissue (BAT) is essential for cold-induced thermogenesis. By using a mouse model with ATGL/HSL deletion in BAT, researchers revealed impa...