A recent @cp-cell.bsky.social paper proposed that double-stranded DNA directly binds and activates SARM1. In a new @pnas.org paper, an international team was unable to reproduce that central finding www.pnas.org/doi/abs/10.1...
pnas.org
Direct activation of SARM1 by dsDNA is not supported by biochemical and cellular evidence | PNAS
Sterile alpha and Toll/interleukin-1 receptor motif–containing protein 1 (SARM1) is
a NAD+-consuming enzyme that drives axon degeneration and is ac...