Reposted by David AngelesRyan North @ryannorth.ca · 23/09/2026Pompeii is a UNESCO world heritage site not because it was remarkable in its prime, but because it survived to our era untouched: one moment, preserved for all time. But future generations won't know what OUR world was like unless we do the same. This is why we MUST bury Toronto with a volcano 11867601625
David Angeles @davidangeles.bsky.social · 22/09/2026Don't be a postdoc. That's how. Biggest lie ever played on a scientist 000
David Angeles @davidangeles.bsky.social · 25/08/2026Congrats @katecavanaugh.bsky.social --it has been really amazing to watch this work grow from the sidelines over the past many years. Glad it is out! 010
Reposted by David AngelesKate Cavanaugh @katecavanaugh.bsky.social · 01/10/2025See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵... 1125881
David Angeles @davidangeles.bsky.social · 23/07/2026I am chairing the Graduate Research network session today @SocDevBio. If you're around come say hi! 100
David Angeles @davidangeles.bsky.social · 19/07/2026Am I the only person who is a bit tired of hearing mitochondria are overlooked? They are very much not. 000
Reposted by David Angelesc0nc0rdance @c0nc0rdance.bsky.social · 08/07/2026"The dream of every cell is to become two cells." - François Jacob, paraphrasing Jacques Monod. 1410613
David Angeles @davidangeles.bsky.social · 24/06/2026"shouldn't have been done" -- are we really advocating for censorship in scientific biometrics now? I don't care for rankings but it really concerns me that our community increasingly talks in ways that are so polarizing. 110
David Angeles @davidangeles.bsky.social · 23/06/2026Only in biology do we a) feel bad for the absolutely richest labs in the world, and b) argue that a three year runway is unreasonable. 100
Reposted by David AngelesAshley Albright @aralbright.bsky.social · 19/06/2026[1/n] Our preprint-in-progress on RNA regionalization in Stentor is no longer in progress! Now @pnas.org 🥳 Turns out a single cell isn't a homogenous soup… it has molecular geography, including things like regionalized transcription factors. Think bicoid, but in a ciliate.pnas.orgGenome-wide analysis of mRNA regionalization in a giant single cell | PNASThe molecular mechanisms that produce cell structure are poorly understood. The giant ciliate Stentor coeruleus is a unicellular model organism who... 14616
Reposted by David AngelesDavid Ho @davidho.bsky.social · 18/06/2026Vaccines are humanity's greatest scientific achievement.bbc.co.ukCervical cancer deaths fall to zero in young women given HPV vaccineA new study finds that hundreds of lives have been saved since school-age girls were offered the HPV jab in 2008. 81048276
David Angeles @davidangeles.bsky.social · 16/06/2026If 15-20% of labs have >20 scientists (call these "large labs"), this means ~40 percent of scientists work in "large labs" 132
David Angeles @davidangeles.bsky.social · 15/06/2026Who chooses a conference venue in a teeny tiny town where everything closes at 8pm in hurricane season in hot Florida. 000
David Angeles @davidangeles.bsky.social · 11/06/2026If you're a biologist, you essentially cannot use Fable 5 yet 😭 000
David Angeles @davidangeles.bsky.social · 06/06/2026she is a major reason I was able to go to grad school. Miss you, Sue! 010
Reposted by David AngelesAdmirable Women @admirablewomen.bsky.social · 05/06/2026Molecular biologist & geneticist Susan Lindquist (b. #OTD in 1949) was a pioneer in studying protein folding. Her research demonstrated protein folding errors contribute heavily to neurodegenerative conditions like Alzheimer's & Parkinson's diseases. National Medal of Science in 2010. #WomenInSTEM 8724171
Reposted by David AngelesRebecca R Helm @rebeccarhelm.bsky.social · 10/04/2026This deep sea creature is as sharp & clear as broken class, & can grow as long as your hand. This giant amphipod, (Cystisoma) only has two colored body parts: the dense orange stomach/egg pouch, & two MASSIVE eyes, which are a glittering holographic orange layer completely covering its head. 📽️ MBARI 10669225
Reposted by David AngelesMichael D. Green, PhD @michaeldgreen.phd · 28/05/2026President of MIT not mincing words today in @statnews.com www.statnews.com/2026/05/27/s... 447188346434
David Angeles @davidangeles.bsky.social · 23/05/2026Yes, especially so when you are a biologist for whom 90% works is an astounding success. 000
Reposted by David AngelesNico Stuurman @nicostuurman.bsky.social · 21/05/2026I'll be writing a few posts about new features in Micro-Manager. If you are interested in those, please follow @micro-manager.bsky.social. 0117
David Angeles @davidangeles.bsky.social · 18/05/2026The pearl clutching over generated references is a bit funny. Hallucinated references may be new, but the age old problem of missing citations or citations that have nothing to do with the text, self citations, or citations of friends--these are all equally harmful and prevalent and ignored problems 000
David Angeles @davidangeles.bsky.social · 15/05/2026i shudder to think of the rather large number of times i myself have entered a citation incorrectly. pray tell me folks: how do you tell a hallucinated reference from a human mistake? i am all for minimizing AI slop, but this policy seems likely to catch as much non-AI as AI. 100
David Angeles @davidangeles.bsky.social · 11/05/2026chromatin is related to gene expression? at the single cell level? what! 010
Reposted by David AngelesPhoto Diary @amablephoto.bsky.social · 10/05/2026. 📷 Kristin Sundberg . #PhotoOfTheDay #Photography #BlueskyPhotography #PhotoKind 459755
Reposted by David AngelesAlexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 07/05/2026#RIP Pierre Chambon (1931-2026) via @alainberetz.bsky.social one of the last giants in biology: PARP, nuclear receptors, RNA Pol II, nucleosome, promoters, split genes 310052
David Angeles @davidangeles.bsky.social · 08/05/2026scientists: correlative methods do not imply causation. also scientists: 010
Reposted by David AngelesWallace Marshall @wallaceucsf.bsky.social · 09/12/2025you can read about it here: www.biorxiv.org/content/10.1...biorxiv.orgAn Algebraic Approach to Representing Mitochondrial DynamicsThis paper addresses the increasing need for comprehensive mathematical descriptions of cell organization by examining the algebraic structure of mitochondrial network dynamics. Mitochondria are cellu... 011
David Angeles @davidangeles.bsky.social · 10/11/2025Currently at #TERMIS2025, sitting at an award plenary, and though the speaker has done amazing science and is a great speaker, 100% of the data she presented is 2008-2018. Why? I can read all of these papers. The point of conferences used to be to show cutting edge work. 000
Reposted by David AngelesHarold Pimentel @hjp.bsky.social · 29/09/2025Super excited to get this out. This collab started a few years ago and is the first paper from it. Here, with experimental and computational approaches we: 1. establish that cell villages can be just as accurate (one might argue more accurate!) than arrayed-based designs bsky.app/profile/bior... 24021
Reposted by David AngelesMatthew Hodson @matthewhodson.bsky.social · 13/08/202527 years ago, two years after the introduction of effective HIV treatment, the Bay Area Reporter, San Francisco’s lesbian and gay community newspaper, ran ‘No Obits’ as its headline. It was the first edition not to report an AIDS death in almost 15 years. 4376381999
Reposted by David AngelesBuster Jiggs @kdxkawboy.bsky.social · 01/08/2025🗃️ A history mystery solved: where do potatoes come from? Nine million years ago, as the Andes were rising, a tomato cross pollinated a plant from the S. etuberosum lineage. Each plant contributed a gene, that together enabled underground stems to form tubers. www.sciencenews.org/article/pota...sciencenews.orgPotatoes have their roots in ancient tomatoesKnowing potatoes’ origin story could help future-proof the crucial crop against climate threats. 610329
David Angeles @davidangeles.bsky.social · 23/06/2025What does it say if you see circles at the bottom and rectangles at the top? Asking for a friend... 120
Reposted by David AngelesAnshul Kundaje @anshulkundaje.bsky.social · 19/06/2025@saramostafavi.bsky.social (@Genentech) & I (@Stanford) r excited to announce co-advised postdoc positions for candidates with deep expertise in ML for bio (especially sequence to function models, causal perturbational models & single cell models). See details below. Pls RT 1/ 15439
David Angeles @davidangeles.bsky.social · 13/06/2025BO WANG, Stanford Identifying and understanding regeneration suppressors #isscr2025 120
David Angeles @davidangeles.bsky.social · 13/06/2025up next @tatianasg.bsky.social shared and distinct mechanisms in salamander limb and human fingertip regeneration. 100
David Angeles @davidangeles.bsky.social · 13/06/2025ALBERT ERNESTO ALMADA Quiescent preexisting cells in skeletal muscle heal tail injuries in anole lizards 🦎 after tail amputation you see a thing called a blastema forming, muscle only starts to reappear after ~28 days of growth though. #isscr2025 100
David Angeles @davidangeles.bsky.social · 13/06/2025Yesterday i didn't post my conference notes. Let's catch up. animal models in regeneration. MAYSSA MOKALLED washington u in st louis - approaches to spinal cord regeneration. a critical challenge in spinal cord therapies is in providing physical support for implanted neurons. #isscr2025 100
Reposted by David AngelesAndy Moore @aaandmoore.bsky.social · 11/06/2025This is a cumulative maximum intensity projection movie of the endoplasmic reticulum labeled with the membrane marker mEmerald-Sec61B. 815221
David Angeles @davidangeles.bsky.social · 11/06/2025next up masayo takahashi talking about ipsc based replacement of RPEs to cure vision loss from AMD and how to bring an experimental therapy to a trial. makes a big point that there is more to a product than just treatment. #isscr25 100
David Angeles @davidangeles.bsky.social · 11/06/2025Michael S Pepper just gave a powerful talk about inequality in gene and cell therapy access. Africa accounts for 1/5 people on the planet. Of 2850 clinical trials worldwide, there are 5 clinical trials in the entire African continent. Entire room was silent for a couple of minutes afterwards. 000
David Angeles @davidangeles.bsky.social · 11/06/2025Claire Booth talked at #isscr25 about gene editing therapeutics in SCID patients. Basically, we can cure many monogenic types of SCID… but we cant get them to the clinic. heartbreaking to see that the science is solid, yet the reasons for lack of advancement are regulatory. 100
David Angeles @davidangeles.bsky.social · 11/06/2025Bing Guo just gave the coolest talk showing spleen and liver HSCs are established embryonically using a parabiosis experiment, spleen cells “remember” the spleen and can target it when transplanted into the marrow more than bone marrow derived HSCs and they respond to different stimuli. super cool 200
David Angeles @davidangeles.bsky.social · 11/06/2025#ISSCR25 kicks off and i am listening to the cellular agriculture session. multis ceo talking now. they use ai and robotics to automate media prep and test many conditions. 100