iiinova — where your digital self keeps evolving

Dave Matus @davematus.bsky.social · 10/06/2026

🎷🎶 Going to @socdevbio.bsky.social meeting in Vegas? Do you also play jazz? If you’re interested in playing some live jazz with fellow SDB members in Vegas, DM me here. 🎹🎺

static.klipy.com

Will Ferrell's Jazz Flute Solo

ALT: Will Ferrell's Jazz Flute Solo

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Reposted by Dave Matus

shaharbrr.bsky.social @shaharbrr.bsky.social · 06/02/2026

New preprint out! www.biorxiv.org/content/10.6... One of the most salient lessons I learned in all my adventures with screening and protein engineering is the importance of context. The context in which you test a gene or protein determines what function it has.

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Reposted by Dave Matus

Paul Maddox @maddoxfornc.bsky.social · 24/01/2026

Another life has been lost at the hands of Trump’s masked agents. Their violence is unacceptable and un-American. Our leaders must put an end to ICE’s reign of terror and its cruelty.

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Reposted by Dave Matus

Casey Dunn @caseywdunn.bsky.social · 09/01/2026

Our eLetter github.com/caseywdunn/s... responding to a recent Science paper was just posted. The paper found more genes with consistent support for sponge-sister than ctenophore-sister. We found several technical issues that, when corrected, reverse the conclusions and recover ctenophore-sister.

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Dave Matus @davematus.bsky.social · 03/01/2026

Stoked to have helped get this out the door! If you want to inject lots of mRNA into your embryos for higher SnR or to multiplex or to have it last longer… this is the way!

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Dave Matus @davematus.bsky.social · 06/12/2025

You should! We’ve made a bunch of transgenics with it - it’s awesome! I can send you constructs if it’s helpful / just let me know!

Swinburne Lab @swinburnelab.bsky.social · 06/12/2025

Reposted by Dave Matus

Any zebrafish people at ASCB interested in chatting about staygold or in vivo live imaging talk to Aline at her poster at P1238, and additional Swinburne lab posters as at P1238 (Maria) and P1229 on Tuesday

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since you made it all the way to then end - we've already made transgenic lines with the mSG from Ando et al - it's amazing! here's a movie from our Cell Observatory project at the Advanced BioImaging Center 7/7

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We also looked at the new mGold2 variants - a bright new version of an mVenus derived FP - they are super bright (brighter than mNG when imaged with a 514nm laser), but show similar photostability to mNG. Plasmids should be available soon @addgene.bsky.social for all these FPs. 6/7

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At medium and high laser powers the three mSG variants (mSG(E138D) -orange, mSG from Ando et al - red, mBaoJin - green) are all very photostable as expected compared to mNG (blue) 5/7

but where these new FPs really shine is in photostability - we live imaged continuously for 800 frames in single FOVs 4/7

photobleaching of mNeonGreen vs. mStayGold

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We found that the mStayGold variant published by Ando et al. was the brightest in our experiments (mSG(A) in the plot below) 3/7

plot comparing the intensity between mNG and mStayGold variants

We need to build lots of new transgenic lines that are both very bright and photostable, so I was excited to test membrane fusions of the three published mStayGold variants compared to mNeonGreen. We injected mRNA into zebrafish embryos and imaged at 24hpf. 2/7

single confocal images comparing mNG vs. mStayGold

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Systematic comparison of mStayGold and mGold2 variants for live imaging in zebrafish | microPublication

So excited to post my first official #zebrafish paper in my new gig at UC Berkeley with my amazing co-authors @swinburnelab.bsky.social @alinetschanz.bsky.social The TL;DR is that monomeric StayGolds are game changers for in vivo imaging in zebrafish 1/7 micropublication.org/journals/bio...

micropublication.org

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Dave Matus @davematus.bsky.social · 02/07/2025

Had such an amazing time at #Worm25 catching up with old friends and making new ones! Love this community - and remember #justdogenetics!

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Dave Matus @davematus.bsky.social · 25/06/2025

Don’t miss your chance to join an awesome new lab!

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Dave Matus @davematus.bsky.social · 03/06/2025

Strain boring : DQM, but I liked that Sherwood had picked his strain name (NK) after his kids, so I made my allele name (bmd) after my girls and wife (Bria, Maile, Deirdre)

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Reposted by Dave Matus

Daniel Gorelick @danielgorelick.bsky.social · 12/04/2025

Maybe I won the internet today 😄

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Dave Matus @davematus.bsky.social · 11/04/2025

We are looking for scientists with experience in light sheet microscopy, biological imaging, image processing and analysis to join a dedicated team of biologists, engineers and optical physicists that are pushing the boundaries of 4D in vivo imaging! Come help us make movies like this!

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Dave Matus @davematus.bsky.social · 11/04/2025

#hiring! come join us at the Advanced BioImaging Center at UC Berkeley to help us build the #CellObservatory! 1/2 aprecruit.berkeley.edu/JPF04858

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Dave Matus @davematus.bsky.social · 18/03/2025

Yes! Haven’t tested with lifeact yet but have been testing membrane and histone fusions of two new mScarlet3 derivatives - so far mScarlet3S2 is the winner / am sending some plasmids to @itsthewoolab.bsky.social happy to send!

Dave Matus @davematus.bsky.social · 05/03/2025

Can’t wait to come visit you in Vancouver!!!

Governor JB Pritzker @govpritzker.illinois.gov · 23/02/2025

Reposted by Dave Matus

Freezing out the NIH's funding means freezing out American innovation. Research into curing cancer, Alzheimer's, and Parkinson's all delayed. And ultimately it won't just cost us advancements in life-saving research, it will cost us lives.

wbez.org

NIH funding cuts could have ‘devastating impact’ on medical advancements, Chicago researchers say

The National Institutes of Health under President Donald Trump announced this month that it was cutting payments covering overhead costs for research institutions that receive its grants.

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Reposted by Dave Matus

Daniel Gorelick @danielgorelick.bsky.social · 10/02/2025

Trainees who applied for an NIH diversity fellowship whose applications were withdrawn/not being reviewed, there's a NYTimes reporter who wants to talk, especially interested in applicants with disabilities. DM me & I'll put you in touch, will keep all contact confidential. Please amplify

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Dave Matus @davematus.bsky.social · 17/01/2025

Hi Bluesky friends! My 85 year old dad is a finalist in a graphic arts contest to design a wine bottle label for his local Maryland winery - if you think his art worthy it would be awesome if you voted for Bernard! Vote here: docs.google.com/forms/d/e/1F...

An artistic image of a wine glass and grapes for a wine label contest

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Dave Matus @davematus.bsky.social · 29/12/2024

Continuing the tour from Faction to HumbleSea

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Dave Matus @davematus.bsky.social · 21/12/2024

What a cool story! Congrats to all the authors!

Dave Matus @davematus.bsky.social · 19/12/2024

@jbwallingford.bsky.social it’s a UC admin gig and I saw Richard Harland somewhere at this gig… not sure he knows I’m playing…