bit.ly
Mechano-energetic uncoupling in heart failure
Nature Reviews Cardiology, Published online: 22 June 2025; doi:10.1038/s41569-025-01167-6In this Review, the authors focus on the tight interaction between cardiac mechanics and mitochondrial energetics, discuss how this mechano-energetic coupling is disturbed in various acquired and inherited forms of heart failure, and summarize the established and emerging treatments for heart failure that target this mechano-energetic uncoupling.