Sign in

Paul Dark

@darknatter.bsky.social
743 followers 350 following 27 posts

Healthcare professional, educator and researcher, Manchester, UK research.manchester.ac.uk/en/person… 🇬🇧 🇨🇭

PostsRepliesMedia
Paul Dark @darknatter.bsky.social · 19/09/2026
www.bmh.manchester.ac.uk/stories/impr...
bmh.manchester.ac.uk
Improving the treatment of severe respiratory infections and sepsis
A Manchester researcher is helping clinicians treat severe respiratory infections and sepsis more precisely.
011
Reposted by Paul Dark
Seth Trueger @mdaware.org · 31/07/2026
anway, read @iwashyna.bsky.social in @nejm.org I look forward to the day when we know better when to start empiric antifungals I'm sure there will be some frustrating BPA popups during the transition but if we can take better care of patients, lets do it
voices.nejm.org
Choosing Humility in the Face of My Ignorance
A patient in shock forced me to consider how to respond to the limits of my own knowledge and those of the medical field at large.
252
Reposted by Paul Dark
Jack Iwashyna @iwashyna.bsky.social · 31/07/2026
Over on LinkedIn, @darknatter.bsky.social wrote: "Thanks Jack, enjoyable read and hard hitting truths on clinical uncertainty. We've been pondering the "antifungal overuse" question in this setting - the other side of the same coin. Thankfully, research funding is still accessible ...
122
Reposted by Paul Dark
Sepsis Research FEAT @sepsisresearch.bsky.social · 29/04/2026
The team has been in conversation with fellow delegates about rapid diagnostics for sepsis, clinician and nursing care and potential charity partnerships. A chance also to reconnect with @darknatter.bsky.social Prof. Paul Dark, whose continued support for Sepsis Research FEAT's work is invaluable.
141
Paul Dark @darknatter.bsky.social · 09/01/2026
Clinical effectiveness of procalcitonin- or C-reactive protein-guided antibiotic discontinuation protocols for adult patients who are critically ill with sepsis: a rapid systematic review and meta-analysis www.manchester.ac.uk/about/news/t...
manchester.ac.uk
Test shows when safe to stop antibiotics in sepsis patients
A simple blood test can tell doctors when it is safe to stop antibiotics in patients recovering from sepsis, a review led by University of Manchester researchers has found. The review including 21 stu...
030
Paul Dark @darknatter.bsky.social · 28/11/2025
Cost effectiveness of PCT-guided antibiotic duration explored link.springer.com/article/10.1...
link.springer.com
Cost-effectiveness of procalcitonin-guided antibiotic duration for hospitalized patients with sepsis - Critical Care
Background Procalcitonin (PCT)-guided antibiotic duration for critically ill adults with sepsis may be clinically effective and safe. However, cost-effectiveness analyses using clinical trial data for...
030
Reposted by Paul Dark
Sepsis Research FEAT @sepsisresearch.bsky.social · 03/07/2025
As @ics-updates.bsky.social updates #SOA25 congress draws to a close in Birmingham, Professor Paul Dark @darknatter.bsky.social of manchester.ac.uk emphasises the importance of this charity’s priority setting exercise in ensuring that patient needs are addressed by future sepsis research programmes
172
Reposted by Paul Dark
Andy Conway Morris @andymoz78.bsky.social · 06/06/2025
New from @jomcpeake.bsky.social @iculone.bsky.social @darknatter.bsky.social and colleagues from @sepsisresearch.bsky.social the full publication of the Sepsis Research priorities. These set out the research priorities from established sepsis survivors, families, carers and healthcare professionals
doi.org
Top 10 research priorities for sepsis research determined by patients, carers and clinicians
Introduction Sepsis is a high burden syndrome associated with increased morbidity and mortality in both the acute and longer-term phases of illness. Multiple treatment uncertainties remain that requ.....
1137
Paul Dark @darknatter.bsky.social · 19/05/2025
More resesrch results from UK critical care 👏
143
Reposted by Paul Dark
Ben Morton @benmorton.bsky.social · 01/04/2025
Please consider responding to this important survey following on from publication of the ADAPT-Sepsis trial jamanetwork.com/journals/jam... #IDsky #Medsky #ICUsky #Ansky 🧪
jamanetwork.com
Biomarker-Guided Antibiotic Duration for Patients With Suspected Sepsis
This clinical trial assessed whether treatment protocols for monitoring C-reactive protein or procalcitonin safely reduced the amount of time critically ill adults with suspected sepsis received antib...
023
Paul Dark @darknatter.bsky.social · 01/04/2025
Have your say - an invitation to complete this important survey to inform UK implementation sespsis patient care research in PCT-guided antibiotic duration. www.qualtrics.manchester.ac.uk/jfe/preview/... @benmorton.bsky.social @ics-updates.bsky.social @criticalcarereviews.com
qualtrics.manchester.ac.uk
Preview - Qualtrics Survey | Qualtrics Experience Management
The most powerful, simple and trusted way to gather experience data. Start your journey to experience management and try a free account today.
187
Reposted by Paul Dark
JAMA @jama.com · 25/02/2025
Editor’s choice from the February 25 issue. ➡️ Camrelizumab With Chemotherapy in Patients With Early or Locally Advanced TNBC ➡️ Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis ➡️ Essential Thrombocythemia: A Review; and more. ja.ma/4hR14SI #JAMA #MedSky
172
Paul Dark @darknatter.bsky.social · 24/01/2025
www.thebottomline.org.uk/summaries/ad...
thebottomline.org.uk
ADAPT-Sepsis: PCT or CRP Guided Antibiotic Duration
ADAPT-Sepsis: PCT or CRP-guided Antibiotic Duration for Patients with suspected Sepsis Dark et al. JAMA Dec 9 2024. doi:10.1001/jama.2024.26458 Clinical Question For critically ill adults with suspect...
1116
Reposted by Paul Dark
Critical Care Reviews @criticalcarereviews.com · 10/01/2025
The third trial result for #CCR25 in Titanic Belfast in June is the UK-Rox Trial Evaluating the clinical & cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in ICU Register via the QR code or on the CCR website criticalcarereviews.com/meetings/ccr25
0189
Paul Dark @darknatter.bsky.social · 01/01/2025
Aim for 2025
060
Paul Dark @darknatter.bsky.social · 25/12/2024
Schöni Wiehnachte 🇨🇭 🎄 ♥️ ❄️
170
Paul Dark @darknatter.bsky.social · 11/12/2024
@criticalcarereviews.com Congratulations to the newly announced PROFESSOR Rob MacSweeney. Richly deserved for a modest person who works tirelessly in support of improving care of the critically ill through world leadership and creativity for clinical research dissemination with real impact. 👏 Prof.
45110
Reposted by Paul Dark
Critical Care Reviews @criticalcarereviews.com · 10/12/2024
Chief Investigator @darknatter.bsky.social shares insights from the #ADAPTsepsistrial at #CCRdownunder @adaptsepsis @jama.com
0187
Reposted by Paul Dark
Andrew Boyle @aboyle.bsky.social · 09/12/2024
Congratulations @darknatter.bsky.social and team!
041
Reposted by Paul Dark
Ben Millette @benmillette.bsky.social · 09/12/2024
Absolutely fantastic work from @darknatter.bsky.social and team. Looking forward to a deep dive into the paper! #ccrdownunder24
161
Reposted by Paul Dark
Critical Care Reviews @criticalcarereviews.com · 20/11/2024
Registration for the Critical Care Reviews Meeting 2025 is now open ➡️ June 11th to 13th ➡️ Titanic Belfast, Belfast, Northern Ireland The Best Critical Care Trials in the World criticalcarereviews.com/meetings/ccr25
criticalcarereviews.com
CCR25
Critical Care Reviews Meeting 2025, Titanic Belfast, June 11th to 13th. Featuring 12 major critical care trial results
1114
Paul Dark @darknatter.bsky.social · 19/11/2024
Welcome back to Manchester Critical Care Research Forum @UKCCRGroup – Tuesday 16 and Wednesday 17 September 2025 The fifteenth national forum for clinical research in critical care, emergency medicine and acute medicine Hosted by Dr Jonathan Bannard-Smith
043
Paul Dark @darknatter.bsky.social · 13/11/2024
What's your priority ? www.thelancet.com/journals/lan...
thelancet.com
Top ten research priorities for sepsis research: UK James Lind Alliance priority setting partnership
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection.1 Sepsis is a substantial global health problem due to its high incidence and associated m...
196
Paul Dark @darknatter.bsky.social · 12/11/2024
Hope to see you in person or virtually for the results of ADAPT-Sepsis criticalcarereviews.com/meetings/ccr...
criticalcarereviews.com
CCR Down Under
Critical Care Reviews Meeting Down Under - The Edge, Federation Square, Melbourne, December 10th - 11th, 2024
171