Pain is the leading cause of disability worldwide, yet no harmonised self-reported reference framework exists to characterise how its burden is distributed across the lifespan and world regions. Here,...

The human superior temporal gyrus processes acoustic–phonetic properties of speech regardless of whether the language is familiar to the listener, but only encodes word boundaries and language-specific sound sequences if the language is known.

Genetic association tests prioritize candidate genes based on different criteria.

Fillingim et al. show that biological and psychosocial factors jointly predict conditions associated with chronic pain.

Fillingim et al. show that biological and psychosocial factors jointly predict conditions associated with chronic pain.

Fillingim et al. show that biological and psychosocial factors jointly predict conditions associated with chronic pain.

Fillingim et al. show that biological and psychosocial factors jointly predict conditions associated with chronic pain.

Nature - A small, preliminary trial and studies in mice draw links between fibromyalgia and alterations of the gut microbiome.

A genome-wide association study meta-analysis combined with multiomics data of osteoarthritis identifies 700 effector genes as well as biological processes with a convergent involvement of multiple effector genes; 10% of these genes express the target of approved drugs.

Computational modeling reveals how uncertainty transforms harmless stimuli into perceptions of pain.

The thermal grill, in which innocuous warm and cool stimuli are interlaced, can produce a paradoxical burning pain sensation—the thermal grill illusion (TGI). While the mechanisms underlying TGI remai...

A study in a mouse model of obesity and prediabetes demonstrates that recruitment of macrophages to nerves has a protective role in diet-induced peripheral neuropathy.

The posterolateral cortical amygdala and other connected brain regions have a key role in mediating the transition from investigative to aggressive behaviour in male mice.

ALT: a philadelphia flyers mascot is wearing a helmet and sunglasses

Using multimodal imaging, Tohyama et al. show that individuals with migraine have white matter damage in the trigeminal nerve. This damage is associated wi

This cohort study analyzes electroencephalography data from healthy participants to analyze and validate a cortical biomarker signature for pain, which comprised the measures sensorimotor peak alpha f...

The Acute to Chronic Pain Signatures (A2CPS) project is a large-scale, multi-site initiative aimed at identifying biomarkers and biosignatures that predict the transition from acute to chronic pain. T...