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Reposted by ComplexPortal

ComplexPortal @complexportal.bsky.social · 27/04/2026

One example: the multi-aminoacyl-tRNA synthetase complex (MSC), CPX-2469 which streamlines tRNA charging and integrates regulatory signals. Its AIMP and ARS components go beyond translation, shaping immunity and cancer, with roles in tumour suppression and tumorigenesis. See tinyurl.com/38xvav39

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ComplexPortal @complexportal.bsky.social · 27/04/2026

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ComplexPortal @complexportal.bsky.social · 27/04/2026

Visit the Complex Portal to see how these interactions are organized into defined molecular assemblies that make translation more efficient, accurate, and responsive to cellular needs.

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ComplexPortal @complexportal.bsky.social · 27/04/2026

tRNAs may be small, but they’re essential for turning genetic code into proteins -matching specific amino acids to corresponding codons on mRNA, tRNAs ensure that the genetic code is executed with precision.

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Reposted by ComplexPortal

ComplexPortal @complexportal.bsky.social · 02/03/2026

🧬 Oncogenic KRAS mutations (pancreatic, colorectal, lung cancers) stabilize these complexes, sustaining growth signalling. Explore RAS at the complex level → new therapeutic insights. #RAS #KRAS #RASopathies #CancerBiology #ComplexPortal

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ComplexPortal @complexportal.bsky.social · 02/03/2026

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ComplexPortal @complexportal.bsky.social · 02/03/2026

Now curated: • SHOC2-MRAS-PP1 phosphatase complexes (RAF activation; linked to RASopathies incl. Noonan-like syndromes) • KRAS/HRAS-SOS1 activation complexes • KRAS-RAF1 & KRAS/MRAS-PIK3CA effector complexes

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ComplexPortal @complexportal.bsky.social · 02/03/2026

🔬 𝑵𝒆𝒘! 𝐑𝐀𝐒 𝐬𝐢𝐠𝐧𝐚𝐥𝐥𝐢𝐧𝐠 𝐜𝐨𝐦𝐩𝐥𝐞𝐱𝐞𝐬 𝐢𝐧 𝐭𝐡𝐞 𝐂𝐨𝐦𝐩𝐥𝐞𝐱 𝐏𝐨𝐫𝐭𝐚𝐥 RAS proteins function in multi-protein assemblies that drive MAPK & PI3K signalling.

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ComplexPortal @complexportal.bsky.social · 02/03/2026

Integrating of disease reference resources like MONDO, OMIM & EFO into the Complex Portal helps map diseases to complexes a powerful lens for research and clinical insight. #RareDiseaseDay #Genetics #MolecularComplexes #CMT #SAVI

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ComplexPortal @complexportal.bsky.social · 02/03/2026

🔬 Dynein complex variants (e.g. DYNC1H1) impair axonal transport → Charcot-Marie-Tooth disease (CMT). 🔥 STING gain-of-function variants hyperactivate interferon signalling → SAVI.

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ComplexPortal @complexportal.bsky.social · 02/03/2026

💜 Individually rare, collectively affecting millions. Linking variants → protein complexes → phenotypes is key for diagnosis and therapy. Visit the Complex Portal to explore complexes such as the Dynein & STING complexes. tinyurl.com/3whub3ey

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ComplexPortal @complexportal.bsky.social · 02/03/2026

🌍 Rare Disease Day: When Molecular Complexes Break Rare diseases aren’t just “gene disorders” - many disrupt macromolecular complexes, the molecular machines that keep cells running.

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ComplexPortal @complexportal.bsky.social · 16/02/2026

Bridging experimental curation & structural prediction to expand insight into complex composition and architecture. #ComplexPortal #ProteinComplexes #StructuralBiology #huMAP30 #MuSIC #QSProteome

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ComplexPortal @complexportal.bsky.social · 16/02/2026

🔎 Exploring predicted complexes in the Complex Portal Beyond curated entries, the portal also includes computationally predicted protein complexes. Quick tour: tinyurl.com/2wph5wua Includes: 🧬 hu.MAP 3.0 🎵 MuSIC 🧪 QSProteome

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ComplexPortal @complexportal.bsky.social · 09/02/2026

🌉By integrating QSProteome, the Complex Portal bridges experiment-based curation & computational prediction, empowering exploration of alternative structural data. 📖Edward Catoiu et al.,PMID: 41163446 👉 tinyurl.com/4578uktz #ComplexPortal #QSProteome #ProteinComplexes #StructuralBiology #PalssonLab

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ComplexPortal @complexportal.bsky.social · 09/02/2026

🔗 References are available for 4,000 manually curated and 12,960 predicted complexes, with 🧊 interactive 3D models, 📊 quality metrics (pLDDT, ipTM, PAE), 🧾 functional annotations, and 🛠️ community curation.

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ComplexPortal @complexportal.bsky.social · 09/02/2026

🎉 Update from the Complex Portal! 🧬 The Complex Portal now links to QSProteome, a community-driven resource for predicted protein complex structures.

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ComplexPortal @complexportal.bsky.social · 19/01/2026

👏 Thanks to our collaborators and the Complex Portal community! 🔗 Explore: www.ebi.ac.uk/complexporta... #ComplexPortal #ProteinComplexes #IntAct #UniProt #OpenScience #FAIRdata #EMBL_EBI 🎊

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ComplexPortal @complexportal.bsky.social · 19/01/2026

🎉 Complex Portal release 252 is out! 🎉 5,296 manually curated biological complexes are now live, in sync with UniProt 2026_01 🚀 Highlights by species: 🧬 Homo sapiens – 2,499 🌱 Arabidopsis thaliana – 228 🧫 Saccharomyces cerevisiae – 634 🧬 Schizosaccharomyces pombe – 145

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ComplexPortal @complexportal.bsky.social · 14/01/2026

Complex Portal release 252 is out! 5,296 manually curated biological complexes. www.ebi.ac.uk/complexporta... (in sync with UniProt release 2026_01)

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Reposted by ComplexPortal

EMBL Events @events.embl.org · 09/01/2026

Are you working on challenging projects in structural biology? #EMBOMacromolecular will highlight the strategic use of cutting-edge protein structure prediction methods, and recent advances in in situ structural biology. Apply by 18 Feb to join us at EMBL Grenoble! 🧬 s.embl.org/mmo26-01-bl

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ComplexPortal @complexportal.bsky.social · 06/01/2026

👩‍🔬 𝐒𝐨 𝐭𝐡𝐢𝐬 𝐍𝐞𝐰 𝐘𝐞𝐚𝐫, let’s resolve not just to feel healthier, but to understand how our biology really works - guided by evidence, tools, and data that are openly accessible and citable. 🧠✨ #COMPLEXPORTAL #IntAct #UniProt #EMBLEBI #NEWYEAR2026

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ComplexPortal @complexportal.bsky.social · 06/01/2026

Explore key blood & circulation complexes: 1. 🩸 Haemoglobin 🔗 tinyurl.com/3rdhwk3h 2. 🧴 Cholesterol homeostasis 🔗 tinyurl.com/23hvtnzx 3. 🧪 Prothrombinase (coagulation) 🔗 tinyurl.com/34m7f5e7 4. 🛡 Complement C3/C5 convertases 🔗 tinyurl.com/mujtd345

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ComplexPortal @complexportal.bsky.social · 06/01/2026

At the Complex Portal, we curate assemblies from haemoglobin complexes (CPX-2158, CPX-2159, CPX-2160) that carry oxygen, to complexes regulating coagulation (CPX-6221), cholesterol homeostasis (CPX-632), and immune clearance - all essential for healthy circulation.

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ComplexPortal @complexportal.bsky.social · 06/01/2026

🧬 New Year, new health goals - let’s get real: exercise fads, diets & oxygen therapies promise “blood cleansing,” but oxygen transport, circulation, cholesterol, and immune defence rely on real macromolecular complexes, not detox trends.

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Reposted by ComplexPortal

ComplexPortal @complexportal.bsky.social · 02/12/2025

🌿 Why it matters • Excess NH₄⁺ disrupts growth and cellular balance • Species differ in ammonium tolerance, influencing biodiversity • Human-driven nitrogen favours ammonium-tolerant species 💡 Plants aren’t passive nitrogen absorbers-they actively regulate uptake to balance nutrition and stress.

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Reposted by ComplexPortal

ComplexPortal @complexportal.bsky.social · 02/12/2025

🌱 Balancing Act: Plants & Ammonium Plants constantly adjust to shifting nitrogen levels. Ammonium transporters (AMTs) mediate NH₄⁺ uptake, redistribution, & sensing. 💡At high ammonium, AMT complexes rapidly shut down uptake via phosphorylation & later reduce AMT gene expression.

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ComplexPortal @complexportal.bsky.social · 02/12/2025

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ComplexPortal @complexportal.bsky.social · 02/12/2025

This protects plants from ammonium toxicity and shapes species fitness across different nitrogen environments. Learn more via the Complex Portal: tinyurl.com/yn9zzfav

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ComplexPortal @complexportal.bsky.social · 02/12/2025

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Reposted by ComplexPortal

IntAct @intact-ebi.bsky.social · 24/11/2025

Registration is free but essential: tinyurl.com/4v3jf4e9 Speakers: Susie H. and Eliot Ragueneau #Bioinformatics #IntAct #Modelling #BiologicalNetworks #Cytoscape

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Reposted by ComplexPortal

IntAct @intact-ebi.bsky.social · 24/11/2025

Would you like to learn more about molecular interactions and how to explore them across organisms? Join us next week for an introductory webinar where we will walk through the IntAct Portal's approach to molecular network modelling and show how this is implemented within the IntAct Cytoscape app.

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Reposted by ComplexPortal

EMBL-EBI @ebi.embl.org · 25/11/2025

From a farm in the north of England to the frontiers of bioinformatics, our Group Leader Sandra Orchard reflects on a career building the data foundations of modern biology: “AI is showing how vital data curation really is.” www.ebi.ac.uk/about/news/p... 🖥️🧬

ebi.ac.uk

Sandra Orchard: what I’ve learned

EMBL-EBI Team Leader Sandra Orchard reflects on a life in protein science, UniProt data curation, and championing open data standards.

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Reposted by ComplexPortal

EMBL-EBI @ebi.embl.org · 25/11/2025

Upon her retirement from EMBL-EBI, we thank Sandra for her dedication and foundational work on important open data resources including: UniProt Complex Portal @complexportal.bsky.social Gene Ontology @geneontology.bsky.social IntAct @intact-ebi.bsky.social InterPro @interprodb.bsky.social

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Reposted by ComplexPortal

ComplexPortal @complexportal.bsky.social · 06/11/2025

Follow the link to uncover: 🧩 what the complex does in the cell 🔄 pathways it participates in (Reactome) 🧬 and curated disease links (EFO, MONDO, OMIM). PDBe gives the structure — the Complex Portal adds the biology. Together they tell the full story: structure → function → system.

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ComplexPortal @complexportal.bsky.social · 06/11/2025

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ComplexPortal @complexportal.bsky.social · 06/11/2025

🔬 Noticed the new look PDBe? The refreshed Protein Data Bank in Europe now includes direct links to the Complex Portal! Example: PDB 6OOY → TNFA complex (CPX-8826).

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Reposted by ComplexPortal

IntAct @intact-ebi.bsky.social · 05/11/2025

🧫 Explore the curated dataset in IntAct ➡️ tinyurl.com/candidalysin 🎨IntAct Cytoscape visualisation: Candida albicans ECE1 peptides (orange) and their human protein targets (blue) #IntActEBI #Interactome #EMBL

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ComplexPortal @complexportal.bsky.social · 19/10/2025

Let’s make your science more FAIR - Findable, Accessible, Interoperable, and Reusable. #Biocuration #FromBenchToDatabase #FAIRdata #ProteinInteractions #EMBL-EBI #IntAct-EBI #OpenScience #UniProt #DataMatters

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ComplexPortal @complexportal.bsky.social · 19/10/2025

📥 Submit your data here: 🔹 IntAct: tinyurl.com/zzrcx742

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ComplexPortal @complexportal.bsky.social · 19/10/2025

Want your PPI or structural data to make an impact? ✅ Use Identifierss ✅ Include structured tables (e.g. Niri et al. 2021 - PMID: 34197713) ✅ Submit to EMBL-EBI's data resources - IntAct 👉 See Niri’s dataset in IntAct: tinyurl.com/yp8ddheh

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ComplexPortal @complexportal.bsky.social · 19/10/2025

Don’t just publish - be found! 🔍 I didn’t realize how vital biocuration was until I became a curator. A well-curated dataset doesn’t just sit in a paper - it lives on in databases and fuels new discoveries.

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ComplexPortal @complexportal.bsky.social · 12/10/2025

🔗 Explore CPX-6502 (tinyurl.com/wm9vz558) via the @emblebi Complex Portal - mapping all biologically functional protein complexes. #GlobalPNHAwarenessDay #PNH #RareDisease #GPIAnchors #ComplementSystem #GpiGnT #ComplexPortal #EMBLEBI

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ComplexPortal @complexportal.bsky.social · 12/10/2025

🧬 On #GlobalPNHAwarenessDay, we spotlight the GPI-GnT complex - a key enzyme disrupted in PNH, a rare and life-threatening blood disorder. 🧩 Its failure (often via PIGA mutations) removes GPI-anchored proteins, leaving blood cells unprotected from complement attack.

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IntAct @intact-ebi.bsky.social · 01/10/2025

🕸️ Explore the interactome on the IntAct tinyurl.com/35922511. 🆕 New feature: You can now group nodes by orthology 🧩 — stay tuned for more details! #Immunology #Proteomics #MolecularInteractions #HumanImmuneSystem

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