iiinova — where your digital self keeps evolving

ComplexPortal @complexportal.bsky.social · 27/04/2026

One example: the multi-aminoacyl-tRNA synthetase complex (MSC), CPX-2469 which streamlines tRNA charging and integrates regulatory signals. Its AIMP and ARS components go beyond translation, shaping immunity and cancer, with roles in tumour suppression and tumorigenesis. See tinyurl.com/38xvav39

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ComplexPortal @complexportal.bsky.social · 02/03/2026

🧬 Oncogenic KRAS mutations (pancreatic, colorectal, lung cancers) stabilize these complexes, sustaining growth signalling. Explore RAS at the complex level → new therapeutic insights. #RAS #KRAS #RASopathies #CancerBiology #ComplexPortal

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ComplexPortal @complexportal.bsky.social · 16/02/2026

Bridging experimental curation & structural prediction to expand insight into complex composition and architecture. #ComplexPortal #ProteinComplexes #StructuralBiology #huMAP30 #MuSIC #QSProteome

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ComplexPortal @complexportal.bsky.social · 06/01/2026

👩‍🔬 𝐒𝐨 𝐭𝐡𝐢𝐬 𝐍𝐞𝐰 𝐘𝐞𝐚𝐫, let’s resolve not just to feel healthier, but to understand how our biology really works - guided by evidence, tools, and data that are openly accessible and citable. 🧠✨ #COMPLEXPORTAL #IntAct #UniProt #EMBLEBI #NEWYEAR2026

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ComplexPortal @complexportal.bsky.social · 19/10/2025

Want your PPI or structural data to make an impact? ✅ Use Identifierss ✅ Include structured tables (e.g. Niri et al. 2021 - PMID: 34197713) ✅ Submit to EMBL-EBI's data resources - IntAct 👉 See Niri’s dataset in IntAct: tinyurl.com/yp8ddheh

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ComplexPortal @complexportal.bsky.social · 12/10/2025

🧬 On #GlobalPNHAwarenessDay, we spotlight the GPI-GnT complex - a key enzyme disrupted in PNH, a rare and life-threatening blood disorder. 🧩 Its failure (often via PIGA mutations) removes GPI-anchored proteins, leaving blood cells unprotected from complement attack.

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ComplexPortal @complexportal.bsky.social · 22/09/2025

🧠 Today is #WorldAlzheimersDay. 📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression (tinyurl.com/37exu532). #WorldAlzheimersDay #AlzheimersSociety #Complexportal

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ComplexPortal @complexportal.bsky.social · 28/08/2025

🧠 Ever wonder how your tongue detects umami or sweetness? 🧂 Umami is sensed by a GPCR made of TAS1R1 + TAS1R3; sweet by TAS1R2 + TAS1R3. 🍜 Both trigger gustducin proteins, sending signals to your brain (and beyond). 🔬 Learn more: Complex Portal: tinyurl.com/ymd4ews9 #TasteReceptors #GPCR

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ComplexPortal @complexportal.bsky.social · 17/07/2025

🐍 From Dark Myths to Eco Allies: Celebrating #WorldSnakeDay Complex Portal holds several curated venom complexes from Crotalus durissus terrificus, a South American rattlesnake known for its pharmacologically active venom proteins. 🔬 Explore these fascinating complexes: (See tinyurl.com/mz5hmzdf)

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ComplexPortal @complexportal.bsky.social · 02/07/2025

Intronic repeats play big roles evolution, gene regulation & disease. They're linked to disorders like Haemophilia & cancer. Cells keep them in check through RNAi-driven heterochromatin formation. See the S. pombe CLR4 complex (CPX-9241) & learn about its involvement in transcriptional silencing.

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ComplexPortal @complexportal.bsky.social · 27/06/2025

Do you want to learn more about macromolecular complexes? Register for our webinar taking place on 𝗝𝘂𝗹𝘆 𝟵𝘁𝗵, 𝟮𝟬𝟮𝟱! 📅 🔍 Discover more about our latest updates including the Complex Navigator & the integration of ML-predicted complexes (huMap3.0 and MuSIC). ➡️ Register now: tinyurl.com/bdy6wttv

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ComplexPortal @complexportal.bsky.social · 03/06/2025

This month features CUL4A (Q13619). Cullin4-RING E3 ubiquitin ligases (CRL4s) regulate processes including facilitating stalled fork stability & genome integrity. Search the CP using GO:0080008 (tinyurl.com/2zhsy43s) & use the Navigator to explore our range of CRL4 complexes! #MolBiol, #ubiquitin

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ComplexPortal @complexportal.bsky.social · 21/05/2025

May is skin cancer awareness month! We're highlighting Telomerase holoenzyme complex (CPX-265) featuring TERT(UniProt:O14746). ComplexPortal: tinyurl.com/mt7u4wbs & visit UniProt for all melanoma-linked proteins tinyurl.com/mryjvyu7 #MelanomaAwareness, #ComplexPortal, #IntAct-EBI, #UniProt

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ComplexPortal @complexportal.bsky.social · 02/05/2025

We're excited to promote our range of Dynactin & Dynein complexes this month! Visit the Complex Portal to explore the respective orthologous and paralogous complexes! (ebi.ac.uk/complexporta...) #Dynactin, #Dynein, #Intracellulartransport

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ComplexPortal @complexportal.bsky.social · 11/04/2025

Hello Spliceosome enthusiasts! Explore the Spliceosome's catalytic activity on pre-mRNA through a highly dynamic series of compositional states. Visit the CP & use the Navigator tool to compare human Major Spliceosome complexes from various points in their lifecycle (tinyurl.com/yy4fbcp2).

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ComplexPortal @complexportal.bsky.social · 10/04/2025

Complex Portal release 250 is out! 5,049 manually curated biological complexes. www.ebi.ac.uk/complexportal (in sync with UniProt release 2025_02). Come explore our high quality manually-curated complexes!!

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ComplexPortal @complexportal.bsky.social · 04/03/2025

Interested in RASopathy and RAS-driven cancers? This month we feature SHOC-MRAS holophosphatase complexes.....CPX-25716, CPX-25719, CPX-25720. Visit the Complex Portal (www.ebi.ac.uk/complexporta...) to learn more!

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ComplexPortal @complexportal.bsky.social · 12/02/2025

👩‍🔬 Today is International Women and Girls in Science day! 🧪 To celebrate we’re shining the spotlight on two biocurators at the Complex Portal.

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ComplexPortal @complexportal.bsky.social · 12/02/2025

👩‍🔬 Today is International Women and Girls in Science day! 🧪 To celebrate we’re shining the spotlight on two biocurators at the Complex Portal.

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ComplexPortal @complexportal.bsky.social · 31/01/2025

Start 2025 with a look at the Prefoldin-like co-chaperone complex (tinyurl.com/3p8b2arh), it’s multi-functional with roles in proteostasis, protein folding, assembly and stabilization. Visit us to learn more about this and Prefoldin (CPX-6149) & PAQosome (CPX-6145) complexes!

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ComplexPortal @complexportal.bsky.social · 29/01/2025

Want to learn more about our expanded coverage of human complexes, new tools and our new User Interface....come take a Quick Tour!!! www.ebi.ac.uk/training/onl...

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ComplexPortal @complexportal.bsky.social · 02/01/2025

Expertly curated context-specific complexes based on combinatorial experimental and computational approaches from PMID:36179048 (www.pnas.org/doi/full/10....). See Complex Portal for CPX-8828 and related TNF complexes (www.ebi.ac.uk/complexporta...).

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ComplexPortal @complexportal.bsky.social · 12/12/2024

The Complex Portal is now on LinkedIn....come follow us!

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ComplexPortal @complexportal.bsky.social · 10/12/2024

Excited to announce the addition of MuSIC (www.nature.com/articles/s41...) complexes in our latest release of the Complex Portal! Visit the Complex Portal (www.ebi.ac.uk/complexporta...) to learn more….

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ComplexPortal @complexportal.bsky.social · 03/12/2024

A focus on the Myddosome core complex (www.ebi.ac.uk/complexporta...), an innate immune signalling platform which transmits inflammatory signals as a result of TLR/IL1R activation. Search the Complex Portal to find complexes involved in inflammatory responses (www.ebi.ac.uk/complexporta...)

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ComplexPortal @complexportal.bsky.social · 03/12/2024

Very excited to share our latest NAR publication (academic.oup.com/nar/advance-...) describing the addition of predicted complexes from Hu.Map3.0..@kdrew ..and updated features to our User interface

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ComplexPortal @complexportal.bsky.social · 08/03/2021

Our #CotM on #InternationalWomensDay #IWD2021 celebrates @KowaEva's team @EMBL for solving the @yeastgenome cytoplasmic exosome complex:The cytoplasmic exosome is a 3' to 5' exo- and endoribonuclease that is involved in RNA maturation & degradation ebi.ac.uk/complexportal/…

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ComplexPortal @complexportal.bsky.social · 02/02/2021

#CotM: Mitochondrial succinyl-CoA synthetase complex which catalyzes the reversible phosphorylation/dephosphorylation of Succinyl-CoA in the #Krebscycle ebi.ac.uk/complexportal/…

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ComplexPortal @complexportal.bsky.social · 18/01/2021

We've updated the #ComplexTab file: - filename = NCBI Taxon ID - Stoichiometry consistently collapsed - New column: all protein participants identified with @uniprot IDs even if these are members of subcomplexes or protein sets - Readme file updated ebi.ac.uk/complexportal/…

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ComplexPortal @complexportal.bsky.social · 17/11/2020

#CotM: the Membane Attack Complex is the final complex of all 3 #complementPathways of the #innateImmuneSystem. All complexes of the classical, alternative and lectin pathway are now available for #human.Activated by most pathogens 🦠, incl. #SARSCoV2 ebi.ac.uk/complexportal/…

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ComplexPortal @complexportal.bsky.social · 05/11/2020

#YeastComplexome: ~600 complexes with added metadata: stoichiometry, topology, structures, @news4go annotations. Std format, #openaccess #OpenData with @yeastgenome @irbbarcelona @ptck72 @uniprot @PerfettoLivia @pporras @hhermjakob @bmeldal @yeast_papers biorxiv.org/content/10.110…

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ComplexPortal @complexportal.bsky.social · 06/10/2020

#CotM: Luteinizing hormone complexSynthesized & secreted by gonadotropic cells in anterior pituitary gland. Triggers ovulation & development of corpus luteum👩and stimulates Leydig cell production of testosterone👨. See also related FSH complex (CPX-665). ebi.ac.uk/complexportal/…

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ComplexPortal @complexportal.bsky.social · 29/09/2020

First draft of the E.coli complexsome now available with 321 stable protein complexes.Please feedback if you think we have missed any which should be on the list ebi.ac.uk/complexportal/…

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ComplexPortal @complexportal.bsky.social · 16/07/2020

#CotM is Eukaryotic translation initiation factor 4F, #eIF4F, that loads m7GTP-capped mRNAs onto the 40S ribosomal subunit. e.g.structure: #4aza @PDBeurope pathway: R-HSA-72613 @reactome May be involved in #viralreplication of #SARSCoV2. ebi.ac.uk/complexportal/…

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ComplexPortal @complexportal.bsky.social · 18/06/2020

#CotM: for #FathersDay we give you the Oligosaccharyl transferase complex in C. elegans. It contains #dad1 and transfers #sugar (well, glycans) in the first step of protein N-glycosylation 🍫🍪🍰@PDBeurope has the human structure ebi.ac.uk/pdbe/entry/pdb… ebi.ac.uk/complexportal/…

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ComplexPortal @complexportal.bsky.social · 04/05/2020

#CotM: There are now 12 #SARSCoV2 and 12 #SARSCoV (2003) complexes in our latest release. Now also with full @news4go annotations. Here is the RNA-directed RNA polymerase in #SARSCoV (2003):#6nur @PDBeuropeNext release: #MERS ebi.ac.uk/pdbe/entry/pdb… ebi.ac.uk/complexportal/…

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ComplexPortal @complexportal.bsky.social · 16/04/2020

#ComplexViewer Updates: 1. Complexes as participants are displayed by default and colour-coded, e.g. #SARSCoV2 Spike-hACE2 complex (CPX-5683 or the 3-tier CMG-Pol epsilon complex (CPX-1556. 1/2 ebi.ac.uk/complexportal/… ebi.ac.uk/complexportal/…

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ComplexPortal @complexportal.bsky.social · 06/04/2020

Today we announce the release of #CoronavirusComplexes, a collection of 11 complexes of #SARSCoV2 / #COVID19 virus incl complex of Spike-ACE2 (see link) and 3 #SARS complexes. More coronavirus complexes coming in the next release.figure: @PDBeurope #6vw1 ebi.ac.uk/complexportal/…

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ComplexPortal @complexportal.bsky.social · 02/03/2020

CofM: human nuclear (CPX-5223, CPX-5183) and mitochondrial (CPX-5225, CPX-5226) ribosomes, e.g. nuclear 40S subunit:Here is the crystal structure of the mitochondrial 39S: 3j7y ebi.ac.uk/complexportal/…

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ComplexPortal @complexportal.bsky.social · 04/02/2020

Check out the hyperlinks which link you directly from text to complex in @complexportal from this recent article in @FEBSJournal febs.onlinelibrary.wiley.com/doi/full/10.11…

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ComplexPortal @complexportal.bsky.social · 01/01/2020

#CofM (a bit late due to holidays): The Christmas Factor 🎄, i.e. Coagulations factor IXa. Named after Stephen Christmas, the patient in which Factor IX was first described. We wish all our users a Happy New Year 🎉🎇

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ComplexPortal @complexportal.bsky.social · 15/09/2019

Ruedi Aebersold - protein complex formation buffers the proteome from genomic copy number variation #HUPO2019 Use @complexportal to identify #ProteinComplexes in your #proteomics samples ebi.ac.uk/complexportal

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ComplexPortal @complexportal.bsky.social · 09/09/2019

#CotM: is the Minichromosome maintenance 2-7 (MCM2-7) complex, essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Find it in 7 model organisms (human, mouse, frog, fly, worm, budding and fission yeast) by searching with GO:0042555

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ComplexPortal @complexportal.bsky.social · 23/07/2019

Attending #ISMBECCB #ISMBECCB19 #ISMB19 #ISMBECCB2019 #ISMB2019? Visit us at poster #M32 to find out what @emblebi @complexportal can do for you and meet our new team member Kalpana!

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ComplexPortal @complexportal.bsky.social · 03/06/2019

#CotM: Gamma-secretase, GO:0070765,cleaves integral membrane proteins. Responsible for generating the carboxyl terminus of the amyloid beta-protein from precursor APP (P05067), linked to #Alzheimers @alzheimerssoc #ENDALZ @ARUKnews Fig @PDBeurope #5fn2 ebi.ac.uk/complexportal/…

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ComplexPortal @complexportal.bsky.social · 04/04/2019

#CotM: In the spirit of #Easter we proudly present the #EggComplex: Egg-3/4/5 MBK-2 complexPseudophosphatase complex required for oocyte-to-zygote transition that sequesters and modulates the kinase activity of mbk-2 before and during meiosis. ebi.ac.uk/complexportal/…

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ComplexPortal @complexportal.bsky.social · 01/03/2019

CofM: E. coli ATP synthase complexNice structures in @PDBeurope e.g.:and @EMDB_EMPIAR e.g.: ebi.ac.uk/pdbe/entry/emd… ebi.ac.uk/pdbe/entry/pdb… ebi.ac.uk/complexportal/…

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