Protein-based biomaterials are becoming increasingly prevalent in biomedical applications that treat and prevent disease. This Perspective examines the evolution of techniques used to build and design...

Targeted drug delivery is a powerful and promising area of medicine. Therapies that pinpoint precise areas of the body can reduce the medicine dosage and avoid potentially harmful “off target”...

Plasmid PhoCoil from Dr. Cole DeForest's lab contains the insert PhoCoil and is published in Sci Adv. 2025 Aug 29;11(35):eadx3472. doi: 10.1126/sciadv.adx3472. Epub 2025 Aug 27. This plasmid is available through Addgene.

Multiscale analysis reveals that fibroblasts play a more active role in dilated cardiomyopathy than previously suspected.

Cardiomyocyte hypocontractility underlies inherited dilated cardiomyopathy (DCM). Yet, whether fibroblasts modify DCM phenotypes remains unclear despite their regulation of fibrosis, which strongly pr...

PhoCoil is a genetically encoded hydrogel that enables noninvasive delivery and subsequent user-controlled photodegradation.

Though recombinant protein therapeutics hold great potential in treating many diseases, their intravenous delivery introduces challenges with off-target effects and short circulation half-lives. Injec...

Four University of Washington students have been named Goldwater Scholars by the Goldwater Foundation, advancing the University’s tradition of undergraduate academic excellence and...

Grayscale control over local biomaterial biochemistry and mechanics can be rapidly achieved across large constructs using an inexpensive (~$300) and commercially available liquid crystal display (LCD....

Techniques to specifically modulate protein activity are needed to interrogate spatial effects in cellular processes. A genetically encoded method for site-specific protein–protein conjugation based o...