iiinova — where your digital self keeps evolving

Clinical Epidemiology Basel @clinepi-basel.bsky.social · 03/03/2026

Interested in conducting meta-research with on Advancing Equity, Diversity, and Inclusion in Clinical Trials (EDICT)? Applications are open for 16 fully funded PhD positions — including two positions in Basel at the Division of Clinical Epidemiology. Find out more and apply at: www.edictproject.eu

edictproject.eu

EDICT - Advancing Equity, Diversity and Inclusion in Clinical Trials

EDICT is a Marie Skłodowska-Curie Doctoral Network training 16 PhD researchers to transform equity, diversity and inclusion in clinical trials across Europe.

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 30/10/2025

We thank Krebsliga beider Basel and @snsf.ch for the support of the study. 🤝

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 30/10/2025

The study protocol for the process evaluation substudy of the #LIQPLAT trial, which evaluates the use of ctDNA in decision-making for advanced solid cancers, is now published in #BMJOpen. 🔗 Full article: lnkd.in/eFWBhtze ℹ️ More information on the LIQPLAT trial: liqplat.com

lnkd.in

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 08/10/2025

👏 Congratulations to all co-authors 🙏 Many thanks to all participants, SHCS physicians, research personnel, and funders who made this innovation possible! @snsf.ch @FAG Basel

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 08/10/2025

Trials within Cohorts (#TwiCs) is an innovative study design that embeds randomized trials directly within ongoing cohort studies. The Swiss HIV Cohort Study (#SHCS) — a well-established, nationwide cohort — has now implemented the TwiCs design for the first time in Switzerland.

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Reposted by Clinical Epidemiology Basel

JAMA Network Open @jamanetworkopen.com · 06/09/2025

Today at #PRC10: Analysis of 347 RCTs in Europe and Canada in 2016 Co-author @schwenkej.bsky.social found industry-sponsored trials were more often completed and available. 🔗 Read the study: ja.ma/41I2etz @peerreviewcongress.bsky.social

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Reposted by Clinical Epidemiology Basel

Peer Review Congress #PRC11 Coming 2029! @peerreviewcongress.bsky.social · 05/09/2025

Nonregistration, premature discontinuation due to poor recruitment, and nonpublication of #RCT results remain major challenges, especially for nonindustry trials @schwenkej.bsky.social @clinepi-basel.bsky.social @unibas.ch @mcmasteruniversity.bsky.social #OpenScience #MetaResearch #PeerReview

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 28/08/2025

📝 New study: Mental health & substance use among adolescents in Lesotho🇱🇸 Older teens (15–17) most affected: girls → more mental health issues, boys → more substance use. Yet only 17% accessed care. Urgent need for youth-friendly services. Read more: onlinelibrary.wiley.com/doi/10.1111/...

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 30/07/2025

ART works — but strong monitoring & infant care are key to ending vertical HIV transmission. Full article: onlinelibrary.wiley.com/doi/10.1111/...

onlinelibrary.wiley.com

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 30/07/2025

The challenge? Only 44% of cases had viral load monitoring in line with guidelines. Infant testing & prevention were also inconsistent.

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 30/07/2025

In a study of 353 pregnancies among people living with HIV, vertical transmission was just 1% — far below the ~33% expected without treatment.

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 30/07/2025

🤰🤱 New data from Lesotho: Antiretroviral therapy during pregnancy & breastfeeding is preventing infants from HIV. But there’s still more to do. 🧵

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 28/07/2025

Findings show heavy burdens: Hypertension: 17% Diabetes: 4% HIV: 15%

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 28/07/2025

🚨New publication! 📝 Community-Based chronic Care Lesotho (ComBaCaL) cohort profile a cohort of 14,700+ people in rural Lesotho, uncovering the intersection of chronic disease, poverty, & care access.

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 03/07/2025

🥁Now publication on the availability of trial protocols! 🔗Check out the link for the open access paper: www.sciencedirect.com/science/arti... @jclinepi.bsky.social @unibas.ch @dkf.unibas.ch @snsf.ch

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 23/06/2025

Grace Yoon, Natalie Johnson, Moleboheng Mokebe, Palesa Mahlatsi, Malebanye Lerotholi, Niklaus Labhardt, Nadine Tschumi, Alastair van Heerden, Jennifer M. Belus, Irene Falgas-Bague

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 23/06/2025

💡 New study on behavioral health for people with HIV in Lesotho 🇱🇸: Phone-based care has pros & cons, but trusted individuals are key for support & accountability. From Butha-Buthe and Mokhotlong. 🧑‍⚕️📞👥 Read more 👉

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 20/06/2025

🌞 ClinEpi Summer Event 2025 We just wrapped up an unforgettable summer event featuring fun quizzes & games and ending off with an exciting cooking challenge 🍴 A huge thank you to everyone who joined, competed and organised this event, we are already looking forward to the next one!

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 06/06/2025

Grateful to all collaborators@snsf.ch @unibas.ch @dkf.unibas.ch @ox.ac.uk and to all participating journals from the @bmj.com! 🤝

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 06/06/2025

Our secondary analysis of 533 peer reviewer reports found that reminders about reporting guidelines increased reviewer attention—but the effect diminished due to article rejections and limited implementation by authors. 🔗Full publication@jclinepi.bsky.social : www.sciencedirect.com/science/arti...

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 19/05/2025

🚀 Join us for Geneva Digital Health Day 2025! 🌍💻 Felix Gerber will give a short presentation on digital innovation in low- and middle-income countries. 📅 Date: Thursday, 22 May 2025 🕘 Time: 09:00–17:30 CET 📍 Location: Campus Biotech, Geneva, Switzerland 🔗 Register here: gdhub.org/25gdhd/

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 16/05/2025

🚀 New study out Clinical trials often face overoptimistic budgets and funding shortfalls, leading to costly trial discontinuations. We reviewed Swiss budgeting tools and found untested, inconsistent methods without prespecified cost ranges. Article: trialsjournal.biomedcentral.com/articles/10....

trialsjournal.biomedcentral.com

Clinical trial budgeting approaches in Switzerland—a meta-research study - Trials

Background Conducting clinical trials is resource demanding. Mirroring challenges experienced elsewhere, clinical trials conducted in Switzerland often face overoptimistic budget estimations and insuf...

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Reposted by Clinical Epidemiology Basel

The Lancet Respiratory Medicine @lancetrespirmed.bsky.social · 14/05/2025

📰 New Article: Effects of Janus kinase inhibitors in adults admitted to hospital with #COVID19: a systematic review and IPD meta-analysis of randomised clinical trials Findings suggested that JAK inhibitors reduced mortality across all levels of respiratory support 🔗 tinyurl.com/2hprv99v

Research in context panel:

"Our IPDMA presents the most comprehensive summary of all existing randomised evidence (including >96% of participants recruited globally on the topic) and subgroup analyses settling the issue of discordant guidelines. JAK inhibitors seem a safe and efficacious treatment option for adults hospitalised with COVID-19 when given in addition to usual care."

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 15/04/2025

New research was presented from longstanding collaborations, including work by #SolidarMed and the Division of Clinical Epidemiology. The full list of abstracts is available here: 👉 heyzine.com/flip-book/d0...

lnkd.in

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 15/04/2025

Last week in Maseru, leaders from Lesotho’s Ministry of Health and local organisations gathered for the 13th National Health Research Symposium. 🇱🇸📊 The event highlighted the importance of locally led, evidence-based research — now more critical than ever! 🩺📚

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 31/03/2025

We had the pleasure of hosting Prof. @stephensenn.bsky.social in Basel for a public lecture on statistical principles in #RCTs. Thanks to #PPHS for making it possible — and to Prof. Senn for the inspiring talk and visit! @unibas.ch @dkf.unibas.ch

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 14/03/2025

🌍 EVENT: Challenges & Opportunities in Global Mental Health 🧠 Join us at the @swisstph.ch on June 3, 2025 (2:00 PM – 5:00 PM) for a discussion with experts from @columbiauniversity.bsky.social , @uzh-ch.bsky.social, @swisstph.ch , and University Hospital Basel! 🔗 RSVP: nat.johnson@unibas.ch

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 03/03/2025

📅 So please join us on March 26th, 16:15–17:45 in the nicest seminar room at the University of Basel, Seminarraum 201 der alten Universität, Rheinsprung 9.

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 03/03/2025

🚨Save the date! March 26th, Prof. @stephensenn.bsky.social will travel to #Basel and give a presentation on methodology and statistics in #RCTs. He will share his insights on why we randomize trials, the value of balance, whether trials should be representative, and much more.

Seminarraum 201, Alte Universität Basel, Rheinsprung 201, Basel

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 28/02/2025

📢 New publication: Prevalence and factors associated with dementia in Lesotho We found a probable dementia prevalence of 5% in Lesotho, aligning with regional estimates for Africa. 🧠 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

alz-journals.onlinelibrary.wiley.com

Prevalence and factors associated with dementia in Lesotho: A cross‐sectional, population‐based study

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 14/02/2025

— J Brown, L Motaboli, M Lerotholi, M Kohler, K Hänggi, M Mokete, M Chakela, M Kao, M Kopo, M Mokebe, L Urda, B Nsakala, B Lukau, I Ayakaka, A Amstutz, J Ehmer, A Klicpera, T Klimkait, T Glass, J Muhairwe, F Chammartin, N Tschumi, N Labhardt

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 14/02/2025

Looking ahead, we plan to expand drug resistance testing and focus on comorbidities and aging in people living with HIV. (4/4)

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 14/02/2025

We've gathered data on full coverage of HIV viral load testing across two districts in Lesotho, shedding light on gaps in the care cascade and the rollout of dolutegravir. (3/4)

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 14/02/2025

Prospective cohorts, like the Viral Load Cohort North-East Lesotho (VICONEL), are crucial for monitoring service delivery and health outcomes in HIV programs. Our goal: Generate evidence to improve HIV care in Lesotho & beyond. (2/4)

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 11/02/2025

Read the full article here: www.sciencedirect.com/science/arti... (4/4) — Jennifer Belus, Kristen Regenauer, Thanh Lu, Sean Murphy, Alexandra Rose, Yvonne Ochieng, John Joska, Hlombekazi Sybil Majokweni, Lena Skovgaard Andersen, Bronwyn Meyers, Steven Safren, Jessica Magidson

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 11/02/2025

These findings suggest that addressing behavioral health could lead to broader improvements, like higher employment, in populations facing substance use and HIV challenges. (3/4)

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 11/02/2025

The employment rate in the intervention group increased from 13% to 59% over 6 months! Meanwhile, the group receiving only substance use treatment referrals showed a smaller increase (29% to 38%). (2/4)

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 11/02/2025

📊 New study on the effectiveness of behavioral interventions for substance use & HIV. Our pilot study, 'Khanya', shows how brief, skills-based interventions can also improve employment rates! 🧵 (1/4)

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 10/02/2025

🦠 New publication from COVERALL (Corona Vaccine Platform Trial): Low agreement & frequent invalid controls in 2 SARS-CoV-2 T-cell assays in people with compromised immune function. This work honours Annette Audigé for her passion & dedication to research!👏🕊️ journals.plos.org/plosone/arti...

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 04/02/2025

Read the full article here: journals.sagepub.com/doi/10.1177/... (4/4) — Jennifer M. Belus, Alastair van Heerden, Abigail Hines, Thembelihle Pita, YVONNE MDAKANE, Jessica Magidson, Heidi van Rooyen, Ruanne Barnabas

journals.sagepub.com

Sage Journals: Discover world-class research

Subscription and open access journals from Sage, the world's leading independent academic publisher.

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