Simões et al. show that nanobodies originally raised against the chaperone S100B unexpectedly cross-react with Tau as potential pathway-selective modulators of Tau self-assembly.

Cell-clogging amyloids form when proteins improperly aggregate

RNA strand, made of just 45 nucleotides, performs two key reactions required for self-replication

One defining feature of complex organisms is the ability to maintain protein homeostasis beyond cellular boundaries. We review how extracellular proteostasis is organized as a hierarchical network spa...

One defining feature of complex organisms is the ability to maintain protein homeostasis beyond cellular boundaries. We review how extracellular proteostasis is organized as a hierarchical network spa...

TWIN2PIPSA Expert Seminar, por Pietro Sormanni (Yusuf Hamied Department of Chemistry, University of Cambridge, UK).

Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by the intracellular deposition of Tau protein and extracellular deposition of...

Intrinsically disordered proteins and peptides play key roles in biology, but a lack of defined structures and high variability in sequence and conformational preferences have made targeting such syst...

Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) is an early-onset neurological disorder caused by mutations in the SACS gene, resulting in the loss of sacsin function. Sacsin is a m...

Rapid sequencing technique can not only deal with proteins hundreds of amino acids long but can detect modifications

A virtual symposium of ACS Fall 2025 programmed at convenient day times of multiple regions. This Global Virtual Symposia aims to discuss these recent developments comprehensively, enhancing our unde...

Schmid and Walter train a classifier that discerns functionally relevant structure predictions in proteome-wide protein-protein interaction (PPI) screens using AlphaFold-Multimer, and they use this confidence metric to curate a database of 40,000 predicted interactions among ∼300 genome maintenance proteins.