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Matt Hall

@cispt2.bsky.social
1K followers 107 following 136 posts

🇦🇺 SD at NCATS, all about treatments for rare diseases, drug discovery and technologies. Views my own. Etc.

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Reposted by Matt Hall
Thiago Carvalho @cyrilpedia.bsky.social · 31/05/2026
'If a control experiment fails, does that mean that the entire experiment is poorly designed and you must restart from scratch? Often, yes— but not always. I present five examples where failed control experiments triggered entirely new fields of research.' link.springer.com/article/10.1...
link.springer.com
The controls that got out of control - EMBO Reports
EMBO Reports - When experimental controls go wrong, it does not necessarily mean your experiment is flawed. It might well be the first sign of something unexpected.
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Reposted by Matt Hall
C&EN (Chemical & Engineering News) @cenmag.bsky.social · 31/05/2026
Researchers have shown that microplastics, and even smaller nanoplastics, are lofted into the atmosphere. Now an international team of researchers has quantified the potential climate impact of atmospheric micro- and nanoplastics. #chemsky 🧪
cenm.ag
Microplastics could be making the world warmer
Bits of plastic floating in the atmosphere largely act as warming agents
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Reposted by Matt Hall
Ian M. Mackay, PhD (he/him) 🦠🤧🧬📑🦟🧀 @mackayim.bsky.social · 31/05/2026
"He urged the public and healthcare workers not to dismiss early symptoms such as vomiting and headaches, warning that misinformation leads many people to believe they have been poisoned rather than seeking hospital care." www.abc.net.au/news/2026-06...
abc.net.au
Brazil authorities investigate two possible Ebola cases as outbreak grows
The true reach of the Ebola outbreak in central Africa could be much wider than the official figures published by central African authorities, the World Health Organization is warning.
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Reposted by Matt Hall
American Thoracic Society (ATS) @atscommunity.bsky.social · 01/01/2026
NCATS’ Division of Preclinical Innovation is hosting a two-day DPI Outreach to Outstanding Research Scholars event in spring 2026! Late-stage doctoral students and early-stage postdocs are invited to a pre-application webinar on Jan. 6, 2026. Register today: nih.us5.list-manage.com/track/click?...
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Reposted by Matt Hall
Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 08/02/2026
There is currently no cure for #HSV, and patients can develop resistance to the drug used to manage symptoms. But thanks to NCATS' 3D Tissue Bioprinting Program, scientists now have the best model yet for testing new treatments. ncats.nih.gov/news-events/... #3Dprinting #bioprinting #virosky 🧪
A graphic with a quote and modified figure from the linked Nature Communications paper, “Limitations of acyclovir and identification of potent HSV antivirals using 3D bioprinted human skin equivalents” (doi: 10.1038/s41467-025-64245-w). It features Figure 2A, a schematic illustrating the following: “Dermis equivalents were 3D printed onto the apical side of transwell inserts...Keratinocytes were pipetted onto the apical surface of the dermis. In the submerged model, the tissues were infected at the apical surface. In the ALI model, tissues were brought to ALI and then infected at the basolateral surface.” Also a quote from a NCATS article published on January 27, 2026: “This collaborative research showed that the bioprinted 3-D skin tissue model closely replicates the structure and layered organization of human skin and that HSV infects these cells the same way it infects people.”
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Matt Hall @cispt2.bsky.social · 08/02/2026
Love this from Samuel Johnson: “In lexicographers, as in many other arts, naked science is too delicate for the purposes of life”
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Matt Hall @cispt2.bsky.social · 15/01/2026
Today we are hosting Dr Barbara Slusher from John’s Hopkins speaking about her drug discovery research programs - amazing scientist and a full house for her seminar !
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Matt Hall @cispt2.bsky.social · 04/01/2026
This made me happy. And happy new year!
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Matt Hall @cispt2.bsky.social · 13/11/2025
It’s buzzing like the first day of school!!!
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Matt Hall @cispt2.bsky.social · 28/10/2025
How did we get to a place where lower-case ‘l’ is an acceptable symbol for liter/litre?
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Reposted by Matt Hall
Shaun @badger2000.bsky.social · 13/10/2025
So much for another relic from my childhood: cordcuttersnews.com/mtv-is-shutt...
cordcuttersnews.com
MTV is Shutting Down Its Last Music Channels, Marking the End of an Era | Cord Cutters News
Paramount Global has delivered a devastating blow to music fans worldwide, announcing the permanent shutdown of five iconic MTV music channels by December 31, 2025 according to the BBC. For 44 years, ...
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Reposted by Matt Hall
Cell Chemical Biology @cp-cellchembiol.bsky.social · 08/10/2025
Online now! Discovery of a tau-aggregate clearing compound that covalently targets P4HB #chembiol
dlvr.it
Discovery of a tau-aggregate clearing compound that covalently targets P4HB
Conway et al. integrate phenotypic screening with chemoproteomics to discover an aminoindole that potently clears tau aggregates across multiple tauopathy models via covalently targeting of the ER enzyme P4HB, revealing potential therapeutic strategies for neurodegenerative disease.
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Reposted by Matt Hall
Chris Gorski @scigorski.bsky.social · 08/10/2025
MOFs are pretty darn cool. Here's our story, in @cenmag.bsky.social cen.acs.org/people/nobel...
cen.acs.org
The 2025 chemistry Nobel goes to MOFs
Susumu Kitagawa, Richard Robson and Omar M. Yaghi win the prize for developing metal–organic frameworks
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Reposted by Matt Hall
Cordero-Vásquez Lab @cvlab.bsky.social · 03/10/2025
Our new PNAS paper "Enhanced PIEZO1 function contributes to the pathogenesis of sickle cell disease" is out: www.pnas.org/doi/10.1073/... 1/3
pnas.org
Enhanced PIEZO1 function contributes to the pathogenesis of sickle cell disease | PNAS
Sickle cell disease (SCD), an inherited blood disorder caused by a mutation in the β-globin gene, is characterized by sickle erythrocytes that are ...
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Reposted by Matt Hall
STAT @statnews.com · 03/10/2025
Scientists believe factors like diet and chemical exposure could play a role in a condition largely driven by genetics www.statnews.com/2025/10/03/n...
statnews.com
As NIH launches new autism research effort, the focus is on environmental factors
The NIH is making a $50 million bet: Understanding environmental factors will help researchers better understand why some people have autism.
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Reposted by Matt Hall
C&EN (Chemical & Engineering News) @cenmag.bsky.social · 03/10/2025
Ice freshly ejected from Enceladus contains complex organics Reanalyzing data from Cassini's 2008 flyby reveals new, complex organic molecules in the spray from Saturn’s icy moon. cen.acs.org/physical-che... #chemsky 🧪
cen.acs.org
Ice freshly ejected from Enceladus contains complex organics
Reanalyzing data from <i>Cassini</i>'s 2008 flyby reveals new, complex organic molecules in the spray from Saturn’s icy moon
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Matt Hall @cispt2.bsky.social · 04/10/2025
www.fastcompany.com/90375683/an-...
fastcompany.com
An astrophysicist explains one of the most famous album covers of all time
You've probably seen this album art a million times, but what exactly are those wiggly lines?
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Reposted by Matt Hall
Irina Bezsonova @irinabezsonova.bsky.social · 03/10/2025
This October I’m drawing one molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social Day 2/31 Prompt WEAVE N-terminal domain of a Fibrion - a building block of silk fiber produced by silkworms. Pdb: 3UA0 Next prompt is CROWN and I would love your suggestions!
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Matt Hall @cispt2.bsky.social · 02/10/2025
As a little boy, my grandparents gave me this book. This story of Pasteur is the one that made me want to be a scientist. And it doesn’t even mention optical activity!!
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Reposted by Matt Hall
C&EN (Chemical & Engineering News) @cenmag.bsky.social · 02/10/2025
Who will win the #ChemNobel? cen.acs.org/people/nobel... #chemsky 🧪
cen.acs.org
It’s Nobel time. Experts predict who will nab the 2025 chemistry prize
The audience of C&EN's Nobel-prediction webinar votes for obesity drug pioneers to win
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Matt Hall @cispt2.bsky.social · 02/10/2025
As a little boy, my grandparents gave me this book. This story of Pasteur is the one that made me want to be a scientist. And it doesn’t even mention optical activity!!
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Reposted by Matt Hall
STAT @statnews.com · 30/09/2025
President Trump announced on Tuesday that Pfizer has agreed to offer lower prices on its drugs to the Medicaid program and directly to patients www.statnews.com/2025/09/30/t...
statnews.com
Trump strikes deal with Pfizer aimed at lowering prescription drug prices
Pfizer will offer discounted prices on some of its drugs and avoid U.S. tariffs, in a deal with President Trump.
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Reposted by Matt Hall
Matt Hall @cispt2.bsky.social · 17/09/2025
I rarely post about work, but in writing this email today asking how to be reimbursed for the cost of hosting a scientific visitor I wrote this explainer. This is not a complaint - but shows how we have to use our own salaries to enrich our environment and the commitment that takes
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Reposted by Matt Hall
The Society for Functional Precision Medicine @thesfpm.bsky.social · 29/09/2025
We want to congratulate our President, Dr. Tony Letai, on his appointment as Director of the NCI. This announcement marks an historic moment for cancer research. Dr. Letai has been a tireless advocate and visionary leader for functional precision medicine 🧵 www.nih.gov/news-events/...
nih.gov
Secretary Kennedy Swears in Dr. Anthony Letai as Director of the National Cancer Institute
Dr. Letai will serve as NCI’s 18th director.
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Matt Hall @cispt2.bsky.social · 29/09/2025
“dad can you can get me one of those retro digital cameras?”
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Matt Hall @cispt2.bsky.social · 22/09/2025
I missed this paper at the time but love this kind of study: "The total mass, number, and distribution of immune cells in the human body" "an average individual’s immune system consists of approximately 1.8 trillion cells, weighing around 1.2 kg" www.pnas.org/doi/10.1073/...
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Matt Hall @cispt2.bsky.social · 17/09/2025
I rarely post about work, but in writing this email today asking how to be reimbursed for the cost of hosting a scientific visitor I wrote this explainer. This is not a complaint - but shows how we have to use our own salaries to enrich our environment and the commitment that takes
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Reposted by Matt Hall
Matt Hall @cispt2.bsky.social · 09/09/2025
Meeting my trainee for coffee and project strategizing in the amazing NIH Clinical Center. Inspiring.
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Matt Hall @cispt2.bsky.social · 09/09/2025
Merch!
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Matt Hall @cispt2.bsky.social · 09/09/2025
But the poster sessions are buzzing - so much amazing NIH science on show! I got in trouble for standing on a ledge to take this photo….. you’re welcome
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Reposted by Matt Hall
Matt Hall @cispt2.bsky.social · 09/09/2025
It’s that time of year again - NIH Research Festival !
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Matt Hall @cispt2.bsky.social · 09/09/2025
It’s that time of year again - NIH Research Festival !
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Matt Hall @cispt2.bsky.social · 03/09/2025
I must be doing something right - daughter raided my vinyl.
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Reposted by Matt Hall
Matt Hall @cispt2.bsky.social · 22/08/2025
Biomedikum @ki.se
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Matt Hall @cispt2.bsky.social · 22/08/2025
Biomedikum @ki.se
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Matt Hall @cispt2.bsky.social · 21/08/2025
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Reposted by Matt Hall
Nature Reviews Cancer @natrevcancer.nature.com · 13/08/2025
#ResearchHighlight 🚨 In a recent study, the Nussenzweig lab investigated the mechanisms underlying #cytarabine-induced neurotoxicity and provide a mechanistic explanation for the differing neurotoxicity profiles of #gemcitabine. 📖⬇️
nature.com
Same same but different - Nature Reviews Cancer
In a recent study published in Nature, Liu, Wang, et al. investigate the mechanisms underlying cytarabine-induced neurotoxicity and provide a mechanistic explanation for the differing neurotoxicity profiles of other nucleoside analogues, such as gemcitabine.
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Matt Hall @cispt2.bsky.social · 14/08/2025
I struggled with homesickness like this, and remember crying instantly once because there was a kangaroo on TV. It was always just beneath the surface. It took years for me to get through it. www.youtube.com/watch?v=gPXG...
youtube.com
Missing Melbourne - The Frankston superboot who brought America to tears | 7NEWS
YouTube video by 7NEWS Australia
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Reposted by Matt Hall
Matt Hall @cispt2.bsky.social · 31/07/2025
I show this dedication in Volume 1 to 'Inorganic Syntheses' to the organic chemists whenever I can. Solid.
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Reposted by Matt Hall
Helen Branswell 🇨🇦 @helenbranswell.bsky.social · 31/07/2025
The NYC #Legionnaires outbreak has grown to 22 cases, with 1 death. Cases have been reported in Central Harlem (ZIP codes 10027, 10030, 10035, 10037 & 10039) & bordering communities. Sounds like cooling towers (multiple?) may be the source??? www.nyc.gov/site/doh/abo...
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Matt Hall @cispt2.bsky.social · 31/07/2025
I show this dedication in Volume 1 to 'Inorganic Syntheses' to the organic chemists whenever I can. Solid.
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Reposted by Matt Hall
Matt Hall @cispt2.bsky.social · 29/07/2025
I love getting into bed and thinking about all the things I didn’t do today
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Matt Hall @cispt2.bsky.social · 29/07/2025
I love getting into bed and thinking about all the things I didn’t do today
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Reposted by Matt Hall
STAT @statnews.com · 25/07/2025
As the Trump administration looks to reshape biomedicine, it is taking aim at one of the most universal ways scientists study disease and determine whether drugs are safe and may work in people: animal research. www.statnews.com/2025/07/25/n...
statnews.com
NIH, FDA plan to reduce animal testing draws mixed reactions among scientists
As the Trump administration reshapes biomedicine, it wants to change how scientists test drug safety: animal research.
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Matt Hall @cispt2.bsky.social · 24/07/2025
Proud of this new article from us in Nature, with long-term collaborators at Chicago and NCI "NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity" www.nature.com/articles/s41...
nature.com
NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity - Nature
An NNMT inhibitor reduces tumour burden and metastasis in multiple mouse cancer models and restores immune checkpoint blockade efficacy by decreasing cancer-associated-fibroblast-mediated recruitment ...
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Matt Hall @cispt2.bsky.social · 24/07/2025
Proud of this new article from us in Nature, with long-term collaborators at Chicago and NCI "NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity" www.nature.com/articles/s41...
nature.com
NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity - Nature
An NNMT inhibitor reduces tumour burden and metastasis in multiple mouse cancer models and restores immune checkpoint blockade efficacy by decreasing cancer-associated-fibroblast-mediated recruitment ...
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Matt Hall @cispt2.bsky.social · 21/07/2025
It’s take your kids to the gig night. My girls (15 and 13) seeing their first real gig tonight @dinosaurjr.com - AJ’s @snailmail.bsky.social who are giving wonderful Juliana Hatfield vibes !
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Lisa Jarvis @lisamjarvis.bsky.social · 19/07/2025
Wrote about becoming one of the many ladies my age who lifts--and the raft of junk science and grifts out there for perimenopausal women who are trying to stave off muscle and bone loss as we age (gift link):
bloomberg.com
The Most Valuable Menopause Fitness Hack
Middle-aged women aiming to build muscle should be skeptical of "fitfluencers," many of whom promote junk science and grifts.
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Matt Hall @cispt2.bsky.social · 17/07/2025
It's amazing to me that one letter f is the difference between UNFAIR and FUNFAIR
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Matt Hall @cispt2.bsky.social · 13/07/2025
One thing that affects me reviewing: I’m no longer spending time working out how to log in to websites. Why are there separate logins for reviewers and authors? If I can’t log in easily to provide a review (ie my unpaid work) I’m work not to spend time solving that problem.
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