Nature Reviews Molecular Cell Biology, Published online: 08 December 2025; doi:10.1038/s41580-025-00941-1Jamieson and colleagues report the effects of spaceflight on haematopoietic stem and progenitor cells isolated from astronauts.

INTRODUCTION Mutations in SORL1, encoding the sorting receptor Sortilin-related receptor with A-type repeats (SORLA), are found in individuals with Alzheimer's disease (AD). We studied SORLAN1358S, .....

CO2 fertilization of the terrestrial biosphere is limited by nitrogen. Biological nitrogen fixation (BNF) is the dominant natural nitrogen source t...

„... aber das würden wir so nie sagen“: Der Umweltmediziner Hans-Peter Hutter und der Journalist Raoul Mazhar über die faszinierende Welt schnorrender Viren, Würmer und Pilze, die sie in einem neuen B...

„... aber das würden wir so nie sagen“: Der Umweltmediziner Hans-Peter Hutter und der Journalist Raoul Mazhar über die faszinierende Welt schnorrender Viren, Würmer und Pilze, die sie in einem neuen Buch erkunden

People do not have to dismiss or exaggerate the climate threat to justify concerted action.

Hackers are ramping up attacks on academic institutions to access valuable data and to demand ransoms.

Hackers are ramping up attacks on academic institutions to access valuable data and to demand ransoms.

The fast skin-permeable polyzwitterion poly[2-(N-oxide-N,N-dimethylamino)ethyl methacrylate] may enable non-invasive transdermal delivery of insulin, and potentially facilitate the use of other protei...

The fast skin-permeable polyzwitterion poly[2-(N-oxide-N,N-dimethylamino)ethyl methacrylate] may enable non-invasive transdermal delivery of insulin, and potentially facilitate the use of other protei...

Subtle genomic variations between humans and Neanderthals provide clues to how DNA shapes our facial features.

Technique could be used as a cheap way to boost ability of other AI models.

Technique could be used as a cheap way to boost ability of other AI models.

Analyses of fossils and ancient genomics reveal how early human populations bred less wolf-like companions, and might have traded them around the world.

Analyses of fossils and ancient genomics reveal how early human populations bred less wolf-like companions, and might have traded them around the world.

Warum überlebte der moderne Mensch, während der Neandertaler ausstarb? An der Med Uni Graz wird daran geforscht.

Von Michael Nikbakhsh und Edith Meinhart. In der #195 Ausgabe ist Alexander Warzilek zu Gast. Er ist der Geschäftsführer des Österreichischen Presserats und dieses wichtige Instrument der Selbstkontro...

Large language models perform well in self-interested games such as the iterated Prisoner’s Dilemma but struggle in games that require coordination. Social reasoning strategies can improve cooperative...

Worüber jemand lacht, zeigt, wer er wirklich ist. Wir haben nachgezählt: Im Bundestag lacht keine Fraktion so oft wie die AfD.

The spectacle of Roman gladiatorial combat captures the public imagination and elicits significant scholarly interest. Skeletal evidence associated with gladiatorial combat is rare, with most evidence...

The spectacle of Roman gladiatorial combat captures the public imagination and elicits significant scholarly interest. Skeletal evidence associated with gladiatorial combat is rare, with most evidence...

Leptospirosis is a zoonotic bacterial infection that causes considerable morbidity and mortality worldwide. In this Primer, Rajapakse et al. review the epidemiology and pathogenesis of the disease; di...

There is growing concern about rubber-derived compounds (RDCs), predominantly originating from tire and road wear particles. Other consumer products, including sports equipment, also contain RDCs, and human exposure to these compounds is of particular interest due to demonstrated toxicity to animal species. In this study, we investigated RDCs intentionally incorporated into climbing shoes for enhanced performance. We found high concentrations of 15 RDCs in shoe sole samples (Σ15 RDCs: 25–3405 μg/g), aerosol particulate matter (Σ15 RDCs: 2.6–37 μg/g), and settled dust (Σ15 RDCs: 1.5–55 μg/g) in indoor climbing halls. The estimated daily intake via inhalation/ingestion of Σ15 RDCs for climbers and employees in some of these facilities ranged from 1.7 to 48 ng/kg/day, exceeding known intake levels of RDCs from other sources. Abrasion powder resulting from friction between climbing shoes and footholds is the likeliest source of high concentrations of RDCs observed in aerosol particulate matter and settled dust. These findings reveal a previously unknown human exposure route of RDCs.

There is growing concern about rubber-derived compounds (RDCs), predominantly originating from tire and road wear particles. Other consumer products, including sports equipment, also contain RDCs, and human exposure to these compounds is of particular interest due to demonstrated toxicity to animal species. In this study, we investigated RDCs intentionally incorporated into climbing shoes for enhanced performance. We found high concentrations of 15 RDCs in shoe sole samples (Σ15 RDCs: 25–3405 μg/g), aerosol particulate matter (Σ15 RDCs: 2.6–37 μg/g), and settled dust (Σ15 RDCs: 1.5–55 μg/g) in indoor climbing halls. The estimated daily intake via inhalation/ingestion of Σ15 RDCs for climbers and employees in some of these facilities ranged from 1.7 to 48 ng/kg/day, exceeding known intake levels of RDCs from other sources. Abrasion powder resulting from friction between climbing shoes and footholds is the likeliest source of high concentrations of RDCs observed in aerosol particulate matter and settled dust. These findings reveal a previously unknown human exposure route of RDCs.