Sign in

Christopher W. Lynn

@chriswlynn.bsky.social
122 followers 75 following 38 posts

Statistical physics of the brain 🧠 & other complex systems 🦠 | Asst Prof of Physics & QBio at Yale X: @ChrisWLynn Lab: lynnlab.yale.edu/

PostsRepliesMedia
Reposted by Christopher W. Lynn
Nature Physics @natphys.nature.com · 18/05/2026
Simple input–output dependencies explain neuronal activity www.nature.com/articles/s41... #physics
nature.com
Simple input–output dependencies explain neuronal activity - Nature Physics
In neurons, the mapping from inputs to output involves complex biophysical processes. Despite this complexity, it is now shown that simple artificial models explain a large fraction of the variability...
041
Reposted by Christopher W. Lynn
Yale Kavli Institute for Neuroscience @kavliatyale.bsky.social · 21/05/2026
Congratulations to 1-@shreyasaxena.bsky.social @chriswlynn.bsky.social, @kuanawanda.bsky.social 2-@d-zen.bsky.social, Julien Berro, @sathishkrishna.bsky.social, & 3-@dlevenstein.bsky.social, @tristan-geiller.bsky.social for their Kavli Innovative Teams Awards [4/4] medicine.yale.edu/kavli/news-a...
Headshots of researchers Shreya Saxena, Christopher Lynn, and Aaron Kuan with the Kavli Institute for Neuroscience at Yale logo in the lower right-hand corner.Headshots of researchers David Zenisek, Julien Berro, and Sathish Ramakrishnan with the Kavli Institute for Neuroscience at Yale logo in the lower right-hand corner.Headshots of researchers Dan Levenstein and Tristan Geiller with the Kavli Institute for Neuroscience at Yale logo in the lower left-hand corner.
021
Reposted by Christopher W. Lynn
Wu Tsai Institute | Yale University @wutsaiyale.bsky.social · 23/03/2026
Applications are now open for WTI's Graduate Certificate in Brains, Minds, and Machines! Open to first-year Yale PhD students. Learn more: wti.yale.edu/initiatives/graduate-certificate 📅 Deadline: April 16, 2026 🚀 Cohort begins Fall 2026 #KnowTogether
045
Christopher W. Lynn @chriswlynn.bsky.social · 24/02/2026
Sign up to volunteer at the DBIO table at APS! It's a great way to meet other biophysicists (and also get a free t-shirt)
010
Reposted by Christopher W. Lynn
APS Division of Biological Physics @aps-dbio.bsky.social · 24/02/2026
Looking for a way to support DBIO (and meet other biophysicists) at the APS Global Physics Summit? Sign up to volunteer at the DBIO membership table. All volunteers get a DBIO t-shirt 👕 Sign up here: docs.google.com/spreadsheets...
docs.google.com
Volunteer DBIO tablers needed (PLEASE INCLUDE EMAIL AND APS ID)
011
Christopher W. Lynn @chriswlynn.bsky.social · 23/01/2026
Led by the awesome Nick Weaver and big shoutout to our collaborators Rick Betzel and Josh Faskowitz
010
Christopher W. Lynn @chriswlynn.bsky.social · 23/01/2026
This means that while the strongest correlations connect regions within the same cognitive system, correlations between different systems may be much more important for constraining activity than previously thought
100
Christopher W. Lynn @chriswlynn.bsky.social · 23/01/2026
This leads to optimal networks that look vastly different than the strongest correlations: They cluster less and connect the entire brain nearly as efficiently as possible
100
Christopher W. Lynn @chriswlynn.bsky.social · 23/01/2026
Counterintuitively: The most important correlations are not simply the strongest. But why? The answer lies in network structure: While strong correlations naturally cluster, the most important correlations "branch out"
100
Christopher W. Lynn @chriswlynn.bsky.social · 23/01/2026
This means that most correlations in the brain are redundant: They can be predicted from a sparse network of the most important correlations
100
Christopher W. Lynn @chriswlynn.bsky.social · 23/01/2026
We find that the compressibility of the human brain is near the theoretical maximum. 90% of the information in neural activity is packed into only 9% of the correlations
100
Christopher W. Lynn @chriswlynn.bsky.social · 23/01/2026
Given a set of correlations, the maximum entropy quantifies our uncertainty about neural activity. If we can get a large drop in entropy (uncertainty) with only a small number of correlations, then the brain is highly compressible
110
Christopher W. Lynn @chriswlynn.bsky.social · 23/01/2026
Correlations in the human brain tell us which regions are functionally "connected". But how many of these correlations do we really need to predict brain activity? Answer: "very few", thus making the human brain highly compressible 🧵👇 www.pnas.org/doi/full/10....
pnas.org
Quantifying the compressibility of the human brain | PNAS
In the human brain, the allowed patterns of activity are constrained by the correlations between brain regions. Yet it remains unclear which correl...
100
Reposted by Christopher W. Lynn
APS Division of Biological Physics @aps-dbio.bsky.social · 06/01/2026
APS DBIO invites you to submit a striking image representing diverse research in biological physics. The winning images will be advertised at the 2026 Global Physics Summit, and the winners will receive free DBIO t-shirts! Submit here by January 16: docs.google.com/forms/d/e/1F...
docs.google.com
021
Christopher W. Lynn @chriswlynn.bsky.social · 14/11/2025
Got to meet one of my heroes today. John Hopfield broke down barriers for generations of physicists: “Physics at its best is a point of view for understanding the totality of man and the Universe.”
020
Christopher W. Lynn @chriswlynn.bsky.social · 10/10/2025
First paper from the lab! 🤠 Understanding the statistical physics of the brain is hard (in part) because statistical physics is hard. We find a class of max ent models that can be solved EXACTLY in very large neural systems Led by the awesome David Carcamo www.pnas.org/doi/10.1073/...
pnas.org
Statistical physics of large-scale neural activity with loops | PNAS
As experiments advance to record from tens of thousands of neurons, statistical physics provides a framework for understanding how collective activ...
020
Reposted by Christopher W. Lynn
Wu Tsai Institute | Yale University @wutsaiyale.bsky.social · 08/10/2025
WTI's Inspiring Speaker Series continues this week with Timothy Lillicrap, “Model-based reinforcement language for reasoning in games and beyond” 10.9.25 | 10 – 11:15a 100 College St, Workshop 1116 🔗 wti.yale.edu/event/2025-10/inspiring-speaker-tim-lillicrap All Yale community members are welcome.
172
Reposted by Christopher W. Lynn
Quanta Magazine @quantamagazine.org · 08/10/2025
Adding loops into a genome is a complicated and costly business for a cell. New findings suggest that it may be the reason that ancient life became complex. @philipcball.bsky.social reports: www.quantamagazine.org/loops-of-dna...
quantamagazine.org
Loops of DNA Equipped Ancient Life To Become Complex | Quanta Magazine
New work shows that physical folding of the genome to control genes located far away may have been an early evolutionary development.
0225
Reposted by Christopher W. Lynn
Jess Cardin @jess-cardin.bsky.social · 08/10/2025
I thought we would never work on gamma oscillations again, but I was wrong 🤷‍♀️ So happy to see this work out in @nature.com! This was a truly epic project spearheaded by @q-perrenoud.bsky.social. Gamma isn't always an oscillation, but it's critical for sensory encoding and perceptual performance 🧠
0172
Reposted by Christopher W. Lynn
Quentin Perrenoud @q-perrenoud.bsky.social · 08/10/2025
(1/8) My latest study is out in @nature.com ! Kudos to coauthors especially @jess-cardin.bsky.social and to @kavliatyale.bsky.social and @wutsaiyale.bsky.social for support. We find that gamma power in mouse visual cortex is caused by brief events of visual processing www.nature.com/articles/s41...
nature.com
Flexible perceptual encoding by discrete gamma events - Nature
Using a new analytical method for tracking gamma band events in mouse visual cortex, flexible encoding of visual information according to behavioural context is shown.
2336
Reposted by Christopher W. Lynn
Santa Fe Institute @sfiscience.bsky.social · 22/09/2025
Final week to apply for the 2026 SFI Complexity Postdoctoral Fellowships If you're an early-career scholar and passionate about collaborative, transdisciplinary research beyond traditional departments, this is the postdoc fellowship for you. Deadline: Oct 1, 2025 Apply: santafe.edu/sfifellowship
01820
Reposted by Christopher W. Lynn
APS Division of Biological Physics @aps-dbio.bsky.social · 05/09/2025
Biological physics bridges the complex phenomena of life with minimal quantitative models from physics. How should we teach biophysics? Join us for an online panel on "Teaching and Learning Biological Physics" (Sep 17, 5:30pm ET). Registration:
apsphysics.zoom.us
Welcome! You are invited to join a meeting: Teaching and Learning Biological Physics. After registering, you will receive a confirmation email about joining the meeting.
Welcome! You are invited to join a meeting: Teaching and Learning Biological Physics. After registering, you will receive a confirmation email about joining the meeting.
122
Reposted by Christopher W. Lynn
APS Division of Biological Physics @aps-dbio.bsky.social · 05/09/2025
Have a striking image of your biophysics research? 🐭🐒🐛🪰🦠Submit it to the DBIO Image Contest! The winning images will be advertised on shirts and other media at the 2026 Global Physics Summit. Submit here:
forms.gle
011
Reposted by Christopher W. Lynn
APS Division of Biological Physics @aps-dbio.bsky.social · 12/08/2025
Interested in organizing a session at the 2026 APS Global Physics Summit? It's pain free and a great way to get involved in organizing! We're taking nominations for invited DBIO Symposia through August 24:
docs.google.com
Organize a DBIO Invited Symposium at the 2026 Global Physics Summit
We are seeking nominations for 'Invited Symposium' to enhance the DBIO program for the upcoming Global Physics Summit. An invited symposium consists of five 36-minute invited talks related to a topic ...
011
Reposted by Christopher W. Lynn
wbialek.bsky.social @wbialek.bsky.social · 09/08/2025
It was an honor to write this, but also great fun. A chance to look back at the classics, and think about the path forward. #Physics is a beautiful human endeavor. journals.aps.org/prxlife/abst...
journals.aps.org
Emergence of Brains
This review traces how ideas from statistical physics evolved into foundational models of neural computation, shaping modern AI and culminating in the 2024 Nobel Prize in Physics.
16418
Reposted by Christopher W. Lynn
Emily Badger @emmbadger.bsky.social · 02/07/2025
Republicans want states to cut food aid errors. Their bill could do the opposite: www.nytimes.com/2025/07/02/u...
nytimes.com
Republicans Want States to Cut Food Aid Errors. Their Bill Could Do the Opposite.
89319
Reposted by Christopher W. Lynn
Marcelo Mattar @marcelomattar.bsky.social · 02/07/2025
Thrilled to see our TinyRNN paper in @nature! We show how tiny RNNs predict choices of individual subjects accurately while staying fully interpretable. This approach can transform how we model cognitive processes in both healthy and disordered decisions. doi.org/10.1038/s415...
doi.org
Discovering cognitive strategies with tiny recurrent neural networks - Nature
Modelling biological decision-making with tiny recurrent neural networks enables more accurate predictions of animal choices than classical cognitive models and offers insights into the underlying cog...
8328140
Reposted by Christopher W. Lynn
mleighton.bsky.social @mleighton.bsky.social · 05/06/2025
Interested in coarse-graining, irreversibility, or neural activity in the hippocampus? If so, check out our new preprint exploring how maximizing the irreversibility preserved from microscopic dynamics leads to interpretable coarse-grained descriptions of biological systems!
051
Reposted by Christopher W. Lynn
Qiwei Yu @qiweiyu.bsky.social · 05/06/2025
Living systems operate nonequilibrium processes across many scales in space and time. Is there a model-free way to bridge the descriptions at different levels of coarse-graining? Here we find that preserving the evidence of time-reversal symmetry breaking works remarkably well!
081
Christopher W. Lynn @chriswlynn.bsky.social · 05/06/2025
Check out the preprint for much more: "Coarse-graining dynamics to maximize irreversibility" And a massive shout out to the leaders of the project: Qiwei Yu (@qiweiyu.bsky.social‬) and Matt Leighton (@mleighton.bsky.social‬)
010
Christopher W. Lynn @chriswlynn.bsky.social · 05/06/2025
In neural dynamics in the hippocampus, the maximum irreversibility coarse-graining uncovers a large-scale loop of flux in neural space that is directly driven by the animal's movement in physical space.
120
Christopher W. Lynn @chriswlynn.bsky.social · 05/06/2025
In chemical oscillators, the maximum irreversibility coarse-graining picks out macroscopic loops of flux that dominate the dynamics.
110
Christopher W. Lynn @chriswlynn.bsky.social · 05/06/2025
Across a range of living systems, this maximum irreversibility coarse-graining uncovers key biological functions. For example, in models of kinesin (a motor protein that ships cargo inside your cells), we can derive simplified dynamics without losing any irreversibility.
110
Christopher W. Lynn @chriswlynn.bsky.social · 05/06/2025
When living systems burn energy, they drive irreversible dynamics and produce entropy. Under coarse-graining, the apparent irreversibility can only decrease. This means that -- at every level of description -- there's a unique coarse-graining with maximum irreversibility.
110
Christopher W. Lynn @chriswlynn.bsky.social · 05/06/2025
Biology consumes energy at the microscale to power functions across all scales: From proteins and cells to entire populations of animals. Led by @qiweiyu.bsky.social‬ and @mleighton.bsky.social‬, we study how coarse-graining can help to bridge this gap 👇🧵 arxiv.org/abs/2506.01909
162
Christopher W. Lynn @chriswlynn.bsky.social · 05/06/2025
Check out the preprint for much more: "Coarse-graining dynamics to maximize irreversibility" And a massive shout out to the leaders of the project: Qiwei Yu (@qiweiyu.bsky.social) and Matt Leighton arxiv.org/abs/2506.01909
arxiv.org
Coarse-graining dynamics to maximize irreversibility
In many far-from-equilibrium biological systems, energy injected by irreversible processes at microscopic scales propagates to larger scales to fulfill important biological functions. But given dissip...
000
Christopher W. Lynn @chriswlynn.bsky.social · 05/06/2025
In neural dynamics in the hippocampus, the maximum irreversibility coarse-graining uncovers a large-scale loop of flux in neural space that is directly driven by the animal's movement in physical space.
100
Christopher W. Lynn @chriswlynn.bsky.social · 05/06/2025
In chemical oscillators, the maximum irreversibility coarse-graining picks out macroscopic loops of flux that dominate the dynamics.
100
Christopher W. Lynn @chriswlynn.bsky.social · 05/06/2025
Across a range of living systems, this maximum irreversibility coarse-graining uncovers key biological functions. For example, in models of kinesin (a motor protein that ships cargo inside your cells), we can derive simplified dynamics without losing any irreversibility.
100
Christopher W. Lynn @chriswlynn.bsky.social · 05/06/2025
When living systems burn energy, they drive irreversible dynamics and produce entropy. Under coarse-graining, the apparent irreversibility can only decrease. This means that -- at every level of description -- there's a unique coarse-graining with maximum irreversibility.
100
Reposted by Christopher W. Lynn
APS Division of Biological Physics @aps-dbio.bsky.social · 02/06/2025
Science is built on public trust, federal funding, and academic freedom. All of these are currently being eroded, but what can we do? Join us for an online panel on "Being a Voice for Science" (June 11, 2-3pm ET). Info and registration: engage.aps.org/dbio/resourc...
engage.aps.org
Resources - Unit - DBIO
112
Reposted by Christopher W. Lynn
APS Division of Biological Physics @aps-dbio.bsky.social · 16/05/2025
Apply or nominate for DBIO awards by June 2! Awards include: APS Fellowship Max Delbrück Prize in Biological Physics Award for Outstanding Doctoral Thesis Research in Biological Physics
121
Christopher W. Lynn @chriswlynn.bsky.social · 16/05/2025
Huge shoutout to my student David Carcamo for leading this paper, and Nick Weaver and Purushottam Dixit for invaluable contributions! ❤️
000
Christopher W. Lynn @chriswlynn.bsky.social · 16/05/2025
...but these applications are limited by our ability to solve difficult statistical physics problems! We thus need new creative methods in order to construct optimal compressions of complex systems.
100
Christopher W. Lynn @chriswlynn.bsky.social · 16/05/2025
We review emerging applications, which range from neuroscience and biology to machine learning and engineering...
100
Christopher W. Lynn @chriswlynn.bsky.social · 16/05/2025
Starting only with MDL, we show that the optimal details provide as much information about the data as possible while remaining maximally random with regard to all unobserved details This "minimax entropy" principle was proposed 25 years ago but remains largely unexplored
100
Christopher W. Lynn @chriswlynn.bsky.social · 16/05/2025
Information theory makes these intuitions concrete: Each model gives us an encoding of the data, and the shortest code provides the best compression of the data. This is the minimum description length (MDL) principle
120
Christopher W. Lynn @chriswlynn.bsky.social · 16/05/2025
When constructing models of the world, we aim for good compressions: models that are as accurate as possible with as few details as possible. But which details should we include in a model? An answer lies in the "minimax entropy" principle 👇 arxiv.org/abs/2505.01607
110
Christopher W. Lynn @chriswlynn.bsky.social · 16/05/2025
What is the connection between information theory and statistical physics? And how can this connection help us understand the brain? Final installment with the Simplifying Complexity podcast ( @bhcomplexity.bsky.social) podcasts.apple.com/us/podcast/w...
podcasts.apple.com
What can physics tell us about the brain? - Part 2
Podcast Episode · Simplifying Complexity · 05/12/2025 · 31m
030
Christopher W. Lynn @chriswlynn.bsky.social · 28/04/2025
Statistical physics and information theory may seem daunting, but with a little insight they can become intuitive and are actually deeply related. A fun chat on the Simplifying Complexity podcast (@bhcomplexity.bsky.social) podcasts.apple.com/us/podcast/w...
podcasts.apple.com
What can physics tell us about the brain? - Part 1
Podcast Episode · Simplifying Complexity · 04/28/2025 · 35m
031