Mobile membrane tethers dynamically alter wetting properties, driving the localization and organization of biomolecular condensates along complex cellular membrane geometries.

Predicting the effect of a genetic mutation on fitness is a major challenge in evolutionary biology. This study uses fitness effects of a large collection of adaptive yeast mutants in multiple lab env...

Chromosomal topology and transcription are tightly coupled, yet the quantitative impact of topological constraints on transcription, supercoiling, and the potential coupling between neighboring genes ...

Motivated by recent observations that mutation rates can be correlated with individual fitness, we analyze an evolutionary hill-climbing model with fitness-dependent mutation rates. Our results show t...

Spatially segregated rRNA processing dictates nucleolar morphology and drives outward progression of pre-ribosomal RNA through nucleolar phases.

Spatially segregated rRNA processing dictates nucleolar morphology and drives outward progression of pre-ribosomal RNA through nucleolar phases.