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Chris Waudby

@chriswaudby.bsky.social
574 followers 484 following 28 posts

Lecturer in Biomolecular NMR at UCL School of Pharmacy. Pianist, opera lover, swimmer and cyclist with an inadvertent interest in religion and science. He/him 🏳️‍🌈 waudbylab.org orcid.org/0000-0001-7810-3753

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Reposted by Chris Waudby
Prof. Zoë Waller @drzoewaller.bsky.social · 02/07/2026
We are recruiting! We are seeking a Research Technical Specialist in Mass Spectrometry. The main purpose of this position is to provide general and specialist research support including leading on method development in relation to Mass Spectrometry.
ucl.ac.uk
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
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Chris Waudby @chriswaudby.bsky.social · 23/06/2026
Very proud to see Sophia Hazlett presenting her PhD research “Characterisation of small molecule binding using 19F NMR R1ρ relaxation dispersion” at the @ccpnmr.bsky.social conference this morning. Read more at chemrxiv.org/doi/10.26434... #nmrchat
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Reposted by Chris Waudby
Nature Structural & Molecular Biology @natsmb.nature.com · 16/06/2026
New online: Structures of protein folding intermediates on the ribosome
dlvr.it
Structures of protein folding intermediates on the ribosome
Nature Structural & Molecular Biology, Published online: 16 June 2026; doi:10.1038/s41594-026-01814-7Atomistic structural ensembles of protein folding intermediates on the ribosome are resolved by comprehensive 19F nuclear magnetic resonance analyses integrated with molecular dynamics simulations, providing insights into cotranslational folding pathways.
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Chris Waudby @chriswaudby.bsky.social · 17/06/2026
Fun day setting up our first experiments at 1.2GHz - resolution for IDPs is 😍! And a great way for Yishan to wrap up part of her MRes research in the group. @ucllifesciences.bsky.social #nmrchat
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Chris Waudby @chriswaudby.bsky.social · 11/03/2026
NMR Sample Manager for Topspin records sample information alongside your NMR experiments. We've made a one-page cheat sheet with commands and key features that you can print and put beside your spectrometers. Feedback very welcome! 
nmr-samples.github.io/topspin/quic...
nmr-samples.github.io
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Chris Waudby @chriswaudby.bsky.social · 05/03/2026
We’ve made an online version of NMR Sample Manager for viewing and annotating sample metadata outside TopSpin. It reads and writes the same JSON format and runs in Chrome or Edge. There’s still no server, all data remains private on your own computer. #nmrchat nmr-samples.github.io/online/
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Chris Waudby @chriswaudby.bsky.social · 03/03/2026
We've been testing this internally at UCL for several months (thanks @nickynak3.bsky.social!). Thanks also to the NMR centre at the Crick for additional testing. The schema is an early release. I'd welcome input from the community on what information matters. Try it out and get involved! 5/
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Chris Waudby @chriswaudby.bsky.social · 03/03/2026
The metadata format is defined by a versioned JSON schema (v0.1.0) covering solution and solid-state NMR. The goal is an open community standard for sample-level metadata that supports FAIR data practices. #FAIRdata 4/ github.com/nmr-samples/schema
github.com
GitHub - nmr-samples/schema: JSON schema definitions for NMR sample metadata, providing a standardised format for recording sample conditions
JSON schema definitions for NMR sample metadata, providing a standardised format for recording sample conditions - nmr-samples/schema
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Chris Waudby @chriswaudby.bsky.social · 03/03/2026
NMR Sample Manager for TopSpin (v3+) provides replacements for ij, ej, and sx that capture sample info at injection. The 'samples' command opens an editor, timeline and searchable catalogue. Check experiment times and SampleJet positions even without annotations. 3/ nmr-samples.github.io/topspin/
Screenshot of NMR Sample Manager for Topspin showing the experiment timeline view
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Chris Waudby @chriswaudby.bsky.social · 03/03/2026
It's designed to be lightweight so all fields are optional – record as much or as little as you need. There's no server or database, so sample metadata is as private and secure as your raw experimental data. 2/
Screenshot of NMR Sample Manager for Topspin showing sample and buffer compositions.
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Chris Waudby @chriswaudby.bsky.social · 03/03/2026
We've been developing NMR Samples, a set of open-source tools for recording sample information like composition, concentrations, labelling, buffers, tube or rotor details, as human-readable JSON files alongside experimental data directories. #nmrchat #openscience nmr-samples.github.io 1/
nmr-samples.github.io
NMR Samples
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Chris Waudby @chriswaudby.bsky.social · 03/03/2026
We are RECRUITING for maternity cover for our NMR facility at the UCL School of Pharmacy - expected from April until February. Come and join us! Details below, feel free to reach out to me informally for more information. Closing date *9 March*.
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Chris Waudby @chriswaudby.bsky.social · 20/11/2025
Weird. Is the problem happening at the same point each time or is it random? If it’s helpful you could test with my sequence (raw.githubusercontent.com/chriswaudby/...) - though the code looks very similar.
raw.githubusercontent.com
https://raw.githubusercontent.com/chriswaudby/pp/refs/heads/master/sfhmqcf2gpph.nuws.cw
;sfhmqcf2gpph.nuws.cw ;1H,13C SOFAST HMQC ;switch on NUWS with -DNUWS ;option for first-increment only with -DONE_D ;with apodisation-weighted sampling ;with exorcycle on 1H 180 ;phase sensitive ;wit...
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Chris Waudby @chriswaudby.bsky.social · 19/11/2025
What’s your direct TD? Try running with digital acquisition mode instead of baseopt? It uses less memory on the console. Is there a long enough delay for disk access in the sequence? It’s normally 30ms.
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Chris Waudby @chriswaudby.bsky.social · 18/11/2025
PhD student Sophia taking us all through the principles of relaxation dispersion in our group meeting this morning 🧲 #nmrchat @ucllifesciences.bsky.social
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Reposted by Chris Waudby
Prof. Zoë Waller @drzoewaller.bsky.social · 07/11/2025
Dr Chris Morris and I have a new paper in Nucleic Acids Research. This paper has been a long time in the making & was affected by COVID so we are proud to have it published! @shozebhaider.bsky.social @effrosynialexandr.bsky.social @chriswaudby.bsky.social academic.oup.com/nar/article/...
academic.oup.com
Affinity-selected peptide ligands specifically bind i-motif DNA and modulate c-Myc gene expression
Abstract. c-Myc is an oncogene that is dysregulated in ∼70% of cancers. Its multifaceted function complicates effective drug targeting of the protein. i-Mo
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Chris Waudby @chriswaudby.bsky.social · 24/09/2025
So excited that our lab's first home-grown paper is now available on ChemRxiv! Kinetic NMR screening: rapidly quantifying fast ligand dissociation in fragment mixtures using ¹⁹F relaxation dispersion | doi.org/10.26434/che... 🧲🧪
doi.org
Kinetic NMR screening: rapidly quantifying fast ligand dissociation in fragment mixtures using ¹⁹F relaxation dispersion
Ligand-observed NMR is a key tool for detecting weak protein-ligand interactions, but translating binding signals into meaningful affinity measurements remains difficult, limiting the ability to rank ...
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Chris Waudby @chriswaudby.bsky.social · 22/09/2025
It was recorded so I think so - will let you know!
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Chris Waudby @chriswaudby.bsky.social · 19/09/2025
Celebrating the submission of my lab’s first fully home-grown paper 🥂 Appearing on @chemrxiv.org soon!
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Chris Waudby @chriswaudby.bsky.social · 18/09/2025
Looking forward to giving a webinar tomorrow with @nickynak3.bsky.social about our efforts to establish a 19F NMR fragment screening platform at UCL. Register below and join us to find out more! Friday 19th September, 2pm (UK) www.eventbrite.co.uk/e/webinar-fr... #NMRchat #NMR @ucltro.bsky.social
eventbrite.co.uk
Webinar: Fragment Screening using 19F NMR at the UCL School of Pharmacy
Join Dr Nikita Harvey and Dr Christopher Waudby to delve into the subject and interact with research fellows.
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Chris Waudby @chriswaudby.bsky.social · 13/09/2025
Many congratulations Mirek and Tomáš - it was a pleasure to be a part of the day and I’ve come away knowing a lot more about Wnt!
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Reposted by Chris Waudby
Bryjalab @bryjalab.bsky.social · 11/09/2025
The science marathon continues. 🏃 Straight off #EBBM2025, BryjaLab is co-organizing with Tripsianes’ lab at @ceitec.eu the Milestone Minisymposium on Cell Signalling, kicking off today with great talks by @chriswaudby.bsky.social & @michaelranes.bsky.social. More talks & two PhD defenses tomorrow 🎓
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Chris Waudby @chriswaudby.bsky.social · 28/08/2025
I’m carrying out a short survey of NMR TITAN users - if you’ve made use of this tool in your research, or have suggestions for its future development, I’d be grateful for your input: forms.gle/MMXYwSozszhi... #nmrchat
forms.gle
NMR TITAN user survey
This survey aims to assess the impact of NMR TITAN on biomolecular research and identify priorities for future development. The form should take approximately 5 minutes to complete. Your responses may...
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Chris Waudby @chriswaudby.bsky.social · 14/08/2025
Thrilled to be at the opening of the UK’s first 1.2 GHz NMR spectrometer at Warwick University, soon to be followed by a second in Birmingham! A huge investment in the NMR community from @ukri.org - I can’t wait to collect my first spectra and see what new discoveries will emerge! #nmrchat
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Reposted by Chris Waudby
UCL Translational Research Office @ucltro.bsky.social · 14/08/2025
Fragment Screening using 19F NMR at the UCL School of Pharmacy: Principles, Practice, and Applications Date: Friday 19 Sep, 2-3pm Speaker: Dr Nikita Harvey, Specialist Services Manager (NMR); Dr Christopher Waudby, Lecturer in Biomolecular NMR at the School of Pharmacy ✅Register now: bit.ly/4lpBftT
bit.ly
Webinar: Fragment Screening using 19F NMR at the UCL School of Pharmacy
Join Dr Nikita Harvey and Dr Christopher Waudby to delve into the subject and interact with research fellows.
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Chris Waudby @chriswaudby.bsky.social · 08/08/2025
26 July ❤️
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Reposted by Chris Waudby
Nikita Harvey @nickynak3.bsky.social · 10/07/2025
Today we're having a cooling/heating rack installed into our NMR liquid handling robot! This should help keep protein and DNA samples stable during prep for our 19F fragment screening service #NMRchat www.ucl.ac.uk/pharmacy/abo...
Two Bruker engineers installing the cooling rack on the SamplePro Tube liquid handlerBruker SamplePro Tube liquid handler with the new cooling rack installed. The cover is open and the robot is lit by a blue LED strip.
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Reposted by Chris Waudby
xavier salvatella @xsalvatella1.bsky.social · 26/11/2024
This is a great opportunity to join our group as PhD student to investigate the role(s) of intrinsically disordered proteins in biomedicine !
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Chris Waudby @chriswaudby.bsky.social · 25/11/2024
I'll be performing in the UCL Chamber Music Club's next concert, 5.30 pm on Wed 4th Dec. Come and join us for a programme of piano music for 2 and 4 hands spanning three continents. Admission is free and open to all. www.ucl.ac.uk/chamber-musi...
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Chris Waudby @chriswaudby.bsky.social · 25/11/2024
Pushed a new update to NMRTools.jl this afternoon, with some bug fixes and improved compatibility with Windows files. Find out more at: waudbylab.org/NMRTools.jl/... 🧲 #julia
waudbylab.org
Home · NMRTools.jl
Documentation for NMRTools.jl.
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Reposted by Chris Waudby
Adam Clancy @clancylab.bsky.social · 25/11/2024
Bluesky is really taking off with STEM academics across UCL, so I thought it was time we had our own Starter Pack #academicsky #chemsky #stem #sciencesky #research #chemeng go.bsky.app/9ZnMnCd
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Chris Waudby @chriswaudby.bsky.social · 07/11/2023
Looking forward to a seminar this Thursday (9 Nov) from Xavier Salvatella, IRB Barcelona: “Kinetic stabilization of translation-repression condensates by a neuron-specific microexon”. Gavin de Beer LT, Anatomy Building, UCL, 1-2pm. #NMRchat 🧪
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Chris Waudby @chriswaudby.bsky.social · 20/10/2023
Looking forward to presenting this beautiful paper from Uli Hommel and colleagues at Novartis as a case study in biomolecular NMR to our MSc Drug Discovery students this afternoon. 🧪 #NMR
nature.com
Discovery of a selective and biologically active low-molecular weight antagonist of human interleuki...
Interleukin-1β is a pro-inflammatory cytokine of medical importance. Here the authors describe the discovery of a low-molecular weight compound that antagonizes hIL-1β function in cells, demonstrati...
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Reposted by Chris Waudby
Jake Yeston @jakeyeston.bsky.social · 21/09/2023
In Science this week, Rafal Klajn and collaborators use visible light and spatial constraints to build up the disfavored azobenzene isomer Chemsky 🧪 www.science.org/doi/full/10....
science.org
Science | AAAS
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Chris Waudby @chriswaudby.bsky.social · 21/09/2023
Disgusted by the UK government’s abandonment of its climate policy? Turn your anger into something more positive: 1. Sign your lab up to LEAF www.ucl.ac.uk/sustainable/... 2. Pledge to take trains over planes 3. Embed sustainability in your teaching 4. Vote! #AcademicSky 🧪
ucl.ac.uk
LEAF - Laboratory Efficiency Assessment Framework
LEAF is a standard set by UCL to improve the sustainability and efficiency of laboratories. Join the 85 global institutions already taking part and help address the climate and ecological emergencies
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Chris Waudby @chriswaudby.bsky.social · 20/09/2023
Hello 👋 I’m Chris, an NMR spectroscopist and protein chemist at UCL interested in protein (mis)folding and glycan quality control, as well as NMR method and software development (big fan of #julialang). May also post cute photos of our dog. More at waudbylab.org. chemsky #AcademicSky #LGBTSTEM 🧪
waudbylab.org
The Waudby Group
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Chris Waudby @chriswaudby.bsky.social · 20/09/2023
Hi @danirabaiotti.bsky.social please add me as a contributor (lecturer at UCL school of pharmacy)
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