iiinova — where your digital self keeps evolving

Reposted by Chloe Lopez-Lee

Sadaf Amin @sadafamin.bsky.social · 01/07/2025

I am thrilled to announce that I will be starting my lab at @washumedicine.bsky.social, Department of Pathology & Immunology as an Assistant Professor this month. The lab will study the role of innate immunity in neurodegeneration and brain aging. We'll be hiring at all levels. Details soon!

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Reposted by Chloe Lopez-Lee

Eileen Ruth Torres, PhD @ertorres.bsky.social · 25/06/2025

My postdoc work from the Gan Lab is out now! 👇 The incredible @sarahnaguib.bsky.social and @chloelopezlee.bsky.social drove this project to completion and I'm so proud of the work put in and grateful to all the contributions from Gan lab members and collaborators. 🧠

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Chloe Lopez-Lee @chloelopezlee.bsky.social · 25/06/2025

Grateful for the opportunity to co-lead this study with @liganlab.bsky.social, @sarahnaguib.bsky.social, and @ertorres.bsky.social! We peel back layers of the protective Christchurch mutation to identify underlying mechanisms and transfer protection to non-Christchurch models with neurotoxic tau 💫

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Reposted by Chloe Lopez-Lee

Gan Lab @liganlab.bsky.social · 24/06/2025

🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...

sciencedirect.com

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway

The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a cau…

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