Reposted by Maggie ChenAndreas Gschwind @argschwind.bsky.social · 15/07/2026Thrilled to share that our ENCODE enhancer–gene mapping paper is now out in Nature! An encyclopedia of human enhancer–gene regulatory interactions: www.nature.com/articles/s41... Thread 👇 1/nature.comAn encyclopedia of human enhancer–gene regulatory interactions - NatureAn encyclopedia of more than 92 million enhancer–gene regulatory interactions created as part of the ENCODE4 project provides a valuable resource for future studies of gene regulation and human geneti... 18041
Reposted by Maggie ChenJason Tan @yjtan.bsky.social · 30/06/2026Does every enhancer work with every promoter? With @jengreitz.bsky.social and Will Greenleaf, we revisit this long-debated question and resolve an outstanding contradiction in the field. A tour 🧵👇 www.biorxiv.org/content/10.6...biorxiv.orgIntrinsic promoter responsiveness dictates sensitivity to transcriptional activation by enhancersEnhancers activate specific target promoters, but whether intrinsic enhancer-promoter compatibility contributes to this specificity is debated. Recent studies using different reporter assays have reac... 37239
Reposted by Maggie ChenJesse Engreitz @jengreitz.bsky.social · 14/05/2026Why do guinea pigs have so many natural bypass arteries — and mice and humans almost none? We develop in vivo Perturb-seq for endothelial cells to ask how protective collateral arteries are built. Preprint with by Irene Fan, Ronghao Zhou, and Kristy Red-Horse: www.biorxiv.org/content/10.6... 14911
Maggie Chen @chenmaggiesy.bsky.social · 24/03/2026Glad to finally see this fun little story out in @ahascience.bsky.social! Led by the indomitable Anthony Zhu, we were curious to better understand the mechanisms of complement signaling post cardiac injury. www.ahajournals.org/doi/10.1161/...ahajournals.orgEpicardial Complement C3 Activation in Neonatal Cardiac Regeneration | Circulation 020
Reposted by Maggie ChenYannick Lee-yow @yleeyow.bsky.social · 17/01/2026How can we identify circRNAs that might be functional? Together with @jengreitz.bsky.social, Howard Chang, and team, we found that answering this question is much more challenging than previously thought! academic.oup.com/nar/article/... See thread below:academic.oup.comJunction-targeting designs limit the application of CRISPR-Cas13d in circular RNA perturbation studiesAbstract. Circular RNAs (circRNAs) are RNA molecules formed through the backsplicing of linear exons. Several thousand have been identified, yet relatively 184
Reposted by Maggie ChenJesse Engreitz @jengreitz.bsky.social · 19/09/2025New preprint from our lab! What can we learn about the properties of gene regulatory elements by CRISPR’ing a random set of accessible sites in human cells? Find out here: www.biorxiv.org/content/10.1... 👇 1/ 16018
Reposted by Maggie ChenJesse Engreitz @jengreitz.bsky.social · 18/09/2025Excited for a major milestone in our efforts to map enhancers and interpret variants in the human genome: The E2G Portal! e2g.stanford.edu This collates our predictions of enhancer-gene regulatory interactions across >1,600 cell types and tissues. Uses cases 👇 1/ 39342
Maggie Chen @chenmaggiesy.bsky.social · 24/05/2025nothing like when your brilliant wonderful high school science fair partner-in-crime publishes a fascinating scientific story!! Congratulations Liana!! 🧬 030
Reposted by Maggie ChenAAAS Mass Media Fellowship @aaasmassmedia.bsky.social · 24/04/2025This news is hot off the press! We are so excited to present the 2025 #MassMediaFellows! These 17 scientists will spend their summer writing, reporting, and working on their #SciComm skills in news outlets across the country! Learn more about the #MMF50th class here: www.aaas.org/news/aaas-ma... 12713
Reposted by Maggie ChenJesse Engreitz @jengreitz.bsky.social · 17/04/2025Our latest work now online in Cell: Rewriting regulatory DNA to dissect and reprogram gene expression Our new method (Variant-EFFECTS) uses high-throughput prime editing + flow sorting + sequencing to precisely measure effects of noncoding variants on gene expression Thread 👇 111728
Reposted by Maggie ChenMichael Montgomery @michaeltmont.bsky.social · 17/04/2025I am elated to share that our manuscript describing Variant-EFFECTS, a high-throughput technology we developed to precisely and quantitatively measure the effects of CRISPR-mediated edits on gene expression, is now published at @cellpress.bsky.social: authors.elsevier.com/c/1kxgiL7PXu...authors.elsevier.com 49635
Reposted by Maggie ChenWIRED @wired.com · 24/03/2025As graduate programs lose spots and labs face shutdowns following Trump administration cuts to science funding, students and researchers are left to figure out what's next.wrd.cmThe Chaos of NIH Cuts Has Left Early-Career Scientists ScramblingAs graduate programs lose spots and labs face shutdowns following Trump administration cuts to science funding, students and researchers are left to figure out what's next. 15517149
