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Maggie Chen

@chenmaggiesy.bsky.social
274 followers 264 following 4 posts

md-phd'ing at stanford and writing words in fun places 🌈 maggiesychen.github.io

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Reposted by Maggie Chen
Andreas Gschwind @argschwind.bsky.social · 15/07/2026
Thrilled to share that our ENCODE enhancer–gene mapping paper is now out in Nature! An encyclopedia of human enhancer–gene regulatory interactions: www.nature.com/articles/s41... Thread 👇 1/
nature.com
An encyclopedia of human enhancer–gene regulatory interactions - Nature
An encyclopedia of more than 92 million enhancer–gene regulatory interactions created as part of the ENCODE4 project provides a valuable resource for future studies of gene regulation and human geneti...
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Reposted by Maggie Chen
Jason Tan @yjtan.bsky.social · 30/06/2026
Does every enhancer work with every promoter? With @jengreitz.bsky.social and Will Greenleaf, we revisit this long-debated question and resolve an outstanding contradiction in the field. A tour 🧵👇 www.biorxiv.org/content/10.6...
biorxiv.org
Intrinsic promoter responsiveness dictates sensitivity to transcriptional activation by enhancers
Enhancers activate specific target promoters, but whether intrinsic enhancer-promoter compatibility contributes to this specificity is debated. Recent studies using different reporter assays have reac...
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Reposted by Maggie Chen
Jesse Engreitz @jengreitz.bsky.social · 14/05/2026
Why do guinea pigs have so many natural bypass arteries — and mice and humans almost none? We develop in vivo Perturb-seq for endothelial cells to ask how protective collateral arteries are built. Preprint with by Irene Fan, Ronghao Zhou, and Kristy Red-Horse: www.biorxiv.org/content/10.6...
A Perturb-seq screen guided by species divergence uncovers pathways for collateral artery formation
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Maggie Chen @chenmaggiesy.bsky.social · 24/03/2026
Glad to finally see this fun little story out in @ahascience.bsky.social! Led by the indomitable Anthony Zhu, we were curious to better understand the mechanisms of complement signaling post cardiac injury. www.ahajournals.org/doi/10.1161/...
ahajournals.org
Epicardial Complement C3 Activation in Neonatal Cardiac Regeneration | Circulation
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Reposted by Maggie Chen
Yannick Lee-yow @yleeyow.bsky.social · 17/01/2026
How can we identify circRNAs that might be functional? Together with @jengreitz.bsky.social, Howard Chang, and team, we found that answering this question is much more challenging than previously thought! academic.oup.com/nar/article/... See thread below:
academic.oup.com
Junction-targeting designs limit the application of CRISPR-Cas13d in circular RNA perturbation studies
Abstract. Circular RNAs (circRNAs) are RNA molecules formed through the backsplicing of linear exons. Several thousand have been identified, yet relatively
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Reposted by Maggie Chen
Jesse Engreitz @jengreitz.bsky.social · 19/09/2025
New preprint from our lab! What can we learn about the properties of gene regulatory elements by CRISPR’ing a random set of accessible sites in human cells? Find out here: www.biorxiv.org/content/10.1... 👇 1/
bioRxiv - An unbiased survey of distal element-gene regulatory interactions with direct-capture targeted Perturb-seq
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Reposted by Maggie Chen
Jesse Engreitz @jengreitz.bsky.social · 18/09/2025
Excited for a major milestone in our efforts to map enhancers and interpret variants in the human genome: The E2G Portal! e2g.stanford.edu This collates our predictions of enhancer-gene regulatory interactions across >1,600 cell types and tissues. Uses cases 👇 1/
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Maggie Chen @chenmaggiesy.bsky.social · 24/05/2025
nothing like when your brilliant wonderful high school science fair partner-in-crime publishes a fascinating scientific story!! Congratulations Liana!! 🧬
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Reposted by Maggie Chen
AAAS Mass Media Fellowship @aaasmassmedia.bsky.social · 24/04/2025
This news is hot off the press! We are so excited to present the 2025 #MassMediaFellows! These 17 scientists will spend their summer writing, reporting, and working on their #SciComm skills in news outlets across the country! Learn more about the #MMF50th class here: www.aaas.org/news/aaas-ma...
Headshots of the 2025 AAAS Mass Media Science & Engineering Fellows
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Reposted by Maggie Chen
Jesse Engreitz @jengreitz.bsky.social · 17/04/2025
Our latest work now online in Cell: Rewriting regulatory DNA to dissect and reprogram gene expression Our new method (Variant-EFFECTS) uses high-throughput prime editing + flow sorting + sequencing to precisely measure effects of noncoding variants on gene expression Thread 👇
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Reposted by Maggie Chen
Michael Montgomery @michaeltmont.bsky.social · 17/04/2025
I am elated to share that our manuscript describing Variant-EFFECTS, a high-throughput technology we developed to precisely and quantitatively measure the effects of CRISPR-mediated edits on gene expression, is now published at @cellpress.bsky.social: authors.elsevier.com/c/1kxgiL7PXu...
authors.elsevier.com
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Reposted by Maggie Chen
WIRED @wired.com · 24/03/2025
As graduate programs lose spots and labs face shutdowns following Trump administration cuts to science funding, students and researchers are left to figure out what's next.
wrd.cm
The Chaos of NIH Cuts Has Left Early-Career Scientists Scrambling
As graduate programs lose spots and labs face shutdowns following Trump administration cuts to science funding, students and researchers are left to figure out what's next.
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