Chemical Probes Portal @chemicalprobes.org · 17/07/202625 years after the human genome sequence, where are we with precision cancer medicine? Prof Paul Workman reflects on the breakthroughs that have transformed cancer drug discovery, from targeted therapies and AI approaches to the role of chemical probes in understanding and validating new targets. 100 1
Chemical Probes Portal @chemicalprobes.org · 09/07/2026The 11th #ChemicalProbesPortal Hackathon is underway today at the Department of Chemistry, @newcastleuni.bsky.social ! Students and experts working together to evaluate chemical probes. Many thanks to the @mosmedcdt.bsky.social CDT for supporting today’s event! #DrugDiscovery #OpenScience 032 3
Chemical Probes Portal @chemicalprobes.org · 06/07/2026Professor Paul Workman will deliver a keynote at #NextGenerationCancerTherapeutics in Houston this October, joining leaders from academia, biotech & pharma to explore advances in precision medicine, immunotherapy, AI-enabled drug discovery & next-generation cancer therapeutics. 110 1
Chemical Probes Portal @chemicalprobes.org · 03/06/2026The 10th #ChemicalProbes Hackathon was a great success in Naples! 👥 20 participants 🎓 7 expert reviewers 📝 16 new probe reviews produced ⏰ All in just 4 hours Thanks to @EUFEPS and SITELF for hosting—and for the real Italian espresso machine at coffee break! ☕🇮🇹 040 4
Chemical Probes Portal @chemicalprobes.org · 12/02/2026A successful PROTAC Hackathon hosted at the@crick.ac.uk: • 34 participants • 24 reviews generated • 100% reported improved understanding Organised by the Chemical Probes Portal with academic & industry collaboration. Next Hackathon: EUFEPS–SITELF 2026 in Naples 🇮🇹 #ChemicalProbes #PROTACs #EUFEPS 011 1
Chemical Probes Portal @chemicalprobes.org · 05/02/2026Excited about tomorrow! A full house at @crick.ac.uk for the 9th Chemical Probe Hackathon, with experts from GSK, @icr.ac.uk & TheCrick working with PhDs & postdocs to review chemical probes and improve research quality. #ChemicalProbes #ChemBio #OpenScience #Hackathon 050 5
Chemical Probes Portal @chemicalprobes.org · 20/10/2025We brought together 22 researchers & 6 experts for a full day of evaluating GPCR and ion channel probes — and completed 26 reviews! Lots of learning, laughter, and deep discussions about what makes a great chemical probe. #ChemicalProbes #OpenScience #DrugDiscovery #GPCR #IonChannels 140 4
Chemical Probes Portal @chemicalprobes.org · 14/10/2025We’re in Oxford today for the 1st UK Chemical Probes Hackathon! 🎯 Postdocs & PhD students join experts to assess GPCR probes and improve research quality. Hosted by @ChemProbes + @UniofOxford #ChemicalProbes #GPCRs #DrugDiscovery 010 1
Chemical Probes Portal @chemicalprobes.org · 21/07/2025🚀 On July 21, the Chemical Probes Portal celebrates 10 years! Launched after the landmark 2015 @NatChemBio paper by Arrowsmith et al., it now features >1150 compounds, >600 targets, and 1600+ expert reviews—powering better biomedical research. 🧪🔬 👉 chemicalprobes.org #ChemicalBiology @icr.ac.uk 296 9
Chemical Probes Portal @chemicalprobes.org · 28/04/2025🏅 Also, congratulations to Professor Workman on being inducted into the AACR Academy — a wonderful recognition of his contributions to cancer research. (Photos below from the AACR Academy Award Ceremony.) #AACR2025 #CancerResearch #DrugDiscovery #PrecisionOncology #PersonalizedMedicine 020 2
Chemical Probes Portal @chemicalprobes.org · 28/04/2025Reminder: Tomorrow, Professor Paul Workman will give his Meet the Expert Lecture at #AACR: Personalized Molecular Medicine Enabled by Multidisciplinary Approaches to Cancer Drug Discovery and Clinical Development. Details: www.abstractsonline.com/pp8/#!/20273... #AACR2025 #CancerResearch 120 2
Chemical Probes Portal @chemicalprobes.org · 12/03/2025📢Looking ahead to #AACR25 in Chicago — only 6 weeks away! Join the Meet-the-Expert session with Prof. Paul Workman, where he’ll emphasize the critical role of high-quality chemical probes in drug discovery. 📅 April 29, 2025 | ⏰ 5:00-5:45 PM Learn more👇 #CancerResearch 131 3
Chemical Probes Portal @chemicalprobes.org · 05/03/2025The Chemical Probes Portal now covers 601 protein targets, expanding resources for chemical biology & drug discovery! 🧪🔬 New high-quality probes target DCTPP1, MASTL, HCN1, plus E3 ligases & PROTACs for protein degradation. Learn more: www.chemicalprobes.org/news/600-tar... #ChemicalProbes 011 1
Chemical Probes Portal @chemicalprobes.org · 28/02/2025Our Cancer Cell Commentary reviews progress on chemical probes since Arrowsmith et al. (Nat Chem Biol 2015) and the launch of the Chemical Probes Portal. We highlight key issues, propose solutions, and outline a path to a quality probe for every human protein. #ChemicalProbes 012 2
Chemical Probes Portal @chemicalprobes.org · 20/02/2025🔬 The Chemical Probes Hackathon is underway in Vienna! Experts from academia & industry, along with international students, are reviewing kinase inhibitors & PROTACs—advancing biomedical research through collaboration. Excited to see today’s findings! 🚀 #EUFEPS #chemicalprobes 001 1
Chemical Probes Portal @chemicalprobes.org · 28/01/2025🔬 Calling all PhD students & postdocs in chemistry/biology! Join us at the Chemical Probes Hackathon 🧪: 🗓️ Feb 20, 2025 | 10:00–14:30 📍 Vienna, Austria 💡 Evaluate chemical probes w/ experts & improve global science 🌍. 🎓 Earn a Certificate of Attendance! Learn more & register 👇 123 3
Chemical Probes Portal @chemicalprobes.org · 27/12/2024Season’s Greetings and Best Wishes for 2025 from the Chemical Probes Portal! ✨🔬 011 1
Chemical Probes Portal @chemicalprobes.org · 17/12/2024🌟 Exciting news! Introducing #MAINFRAME, a global #OpenScience network uniting #MachineLearning & #CompChem experts to drive innovation in #DrugDiscovery. 🚀 Their mission? Open-source algorithms, real-world benchmarking, and faster, affordable medicine development. Learn more👇 110 1
Chemical Probes Portal @chemicalprobes.org · 11/12/2024Paul Workman, Sharad Verma, Timothy A. Yap, and Jerome Mettetal discussed "Developing Efficacious Drugs with Better Combinability" in a plenary session at the AACR Conference on Optimizing Therapeutic Efficacy and Tolerability through Cancer Chemistry. #AACRchem24 #AACRCICR 021 2
Chemical Probes Portal @chemicalprobes.org · 11/12/2024Paul Workman highlighted the importance of selectivity towards the protein target of interest – both for modern, molecularly-targeted drugs and also for high-quality chemical probes for use in laboratory exploration of protein function. #AACRchem24 @icrlondon.bsky.social @mdanderson.bsky.social 063 6
Chemical Probes Portal @chemicalprobes.org · 23/11/2024🚨 Just Launched! Episode 1 of the Target 2035 Podcast Series 🎧 Join @LabScribbles as they chat with @CherylArrowsmi1, a trailblazer in chemical biology and co-founder of #Target2035. Discover the story behind this ambitious initiative for #OpenScience and #DrugDiscovery. 🎙️ Listen now: Link below 👇 140 4