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Chase Bolt

@chasebolt.bsky.social
126 followers 217 following 36 posts

Chromatin - transcription - genetics - biotech Dinosaurs and UFOs Stabby horror movies

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Chase Bolt @chasebolt.bsky.social · 03/02/2026
Can we just start a gofundme, we collect 1 billion dollars, then we just give it to trump as quid pro quo to end ICE raids? I think he would do it.
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Chase Bolt @chasebolt.bsky.social · 09/01/2026
"Biopharma people are shockingly the most reserved" Shockingly, the people that know the most about the dangers of injecting random shit into your body are most averse to injecting random shit in your body.
nytimes.com
‘Chinese Peptides’ Are the Latest Biohacking Trend in the Tech World
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Chase Bolt @chasebolt.bsky.social · 08/01/2026
weather forecast for freezing fog tonight.
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Chase Bolt @chasebolt.bsky.social · 29/12/2025
I hope all the boomers that voted for Trump enjoy getting their medical care from robots in their sunset years.
nytimes.com
What America Might Look Like With Zero Immigration
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Chase Bolt @chasebolt.bsky.social · 26/12/2025
I want to thank all of the people that said that Trump wouldn't be as bad as Kamala.
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Chase Bolt @chasebolt.bsky.social · 19/12/2025
I haven’t been in the field for a few years but all of the major claims made in the abstract have been demonstrated before. But I haven’t read past the abstract so they may explain in better detail why their findings are new
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Chase Bolt @chasebolt.bsky.social · 19/12/2025
They said there would be wind. I came for the wind.
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Chase Bolt @chasebolt.bsky.social · 07/11/2025
synthetic organisms will give good instruction on what is needed to build it. novel ideas on how evolution of species can happen new databases holding compendia of molecular interactions. scored, annotated and modeled, with convenient links to vendors for synthesis. #biotech #AI
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Chase Bolt @chasebolt.bsky.social · 07/11/2025
This is the kind of thing that makes me want to go back to academia. The future of experiments is incredible. Just some ideas: #biotech #AI
arc-website-git-foundation-model-tool-arc-institute.vercel.app
Evo: DNA foundation modeling from molecular to genome scale | Arc Institute
Introducing Evo, a biological foundation model that generalizes across the fundamental languages of biology: DNA, RNA and proteins. Evo is capable of both prediction tasks, and generative design from ...
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Chase Bolt @chasebolt.bsky.social · 04/11/2025
Ultimately, will people tolerate being given a diagnosis by an AI? I'm not sure. #ai-future
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Chase Bolt @chasebolt.bsky.social · 31/10/2025
Fuck. He is back. Cruising. #halloween
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Chase Bolt @chasebolt.bsky.social · 31/10/2025
There are a bunch of kids going down the street trick or treating and a car went past real slow blaring the Halloween theme song. It was fucking awesome. 🎃👻
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Chase Bolt @chasebolt.bsky.social · 06/10/2025
The enshitification continues. I'm not even a Conservative, I just think it is fucking stupid to remove a gun from a picture when the 27 movies are just two hours of guns. There is a person in this world that gets paid - probably a shit ton of money - to make these meaningless decisions.
joblo.com
Amazon/MGM removes all guns from James Bond digital posters on Prime
007 is without his Walther PPK on the latest digital posters featured on Prime Video for the James Bond series.
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Chase Bolt @chasebolt.bsky.social · 05/10/2025
Here is a clue, make anything other than a fucking IPA.
nytimes.com
Craft Breweries Struggle as Sales and Appetites Wane
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Chase Bolt @chasebolt.bsky.social · 20/09/2025
Thank you Marian!
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Reposted by Chase Bolt
Ars Technica @arstechnica.com · 17/09/2025
arstechnica.com
Distinct digits may have evolved by using DNA that makes the cloaca
Making digits seems to involve gene activity that was needed to make a cloaca.
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Chase Bolt @chasebolt.bsky.social · 18/09/2025
There is only #babyshark
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Chase Bolt @chasebolt.bsky.social · 18/09/2025
Thanks Olga!
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Chase Bolt @chasebolt.bsky.social · 18/09/2025
Thanks Dario!
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Chase Bolt @chasebolt.bsky.social · 18/09/2025
Yes they do!
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Chase Bolt @chasebolt.bsky.social · 17/09/2025
Thank you Neil!
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Chase Bolt @chasebolt.bsky.social · 17/09/2025
Link to the original work (dummy). www.nature.com/articles/s41...
nature.com
Co-option of an ancestral cloacal regulatory landscape during digit evolution - Nature
The regulatory landscape controlling Hoxd gene expression in tetrapod digit development was probably co-opted from a pre-existing cloacal regulatory mechanism, as evidenced by the effects of gene...
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Chase Bolt @chasebolt.bsky.social · 17/09/2025
Our work exploring a new explanation for the regulation of Hoxd genes and the #fin-to-limb transition. 🧪 It was an absolute joy working on this w/ @aurhin.bsky.social and @homeobox.bsky.social @denisduboule.bsky.social @neilshubin.bsky.social #evo-devo #InHoxWeTrust
nytimes.com
How Did Hands Evolve? The Answer Is Behind You.
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Chase Bolt @chasebolt.bsky.social · 17/09/2025
There is a lot of concern about leaked genetic data, but what I wonder is, can a "reputable" legal entity like a health insurance company use this information? Or the government? Wouldn't the chain of custody be unreliable? #genetic #privacy
science.org
The precarious future of consumer genetic privacy
Congress and other lawmakers must act to robustly protect direct-to-consumer genetic data and biospecimens into the future
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Chase Bolt @chasebolt.bsky.social · 14/09/2025
sequence that dude
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Chase Bolt @chasebolt.bsky.social · 12/09/2025
Merry Crispus!
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Reposted by Chase Bolt
Alex Stark @alex-stark.bsky.social · 11/09/2025
Join this year's CSH Asia Systems Biology of Gene Regulation & Genome Editing meeting in beautiful Suzhou, China, Oct 20-24. Let's bring the international communities together! Abstract deadline Sept 19! Infos and registration at csh-asia.org?content/2767. Please repost!
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Chase Bolt @chasebolt.bsky.social · 11/09/2025
"the quest for drug targets have meanwhile reduced much of cancer research from a scholarly biological discipline to a transactional operation concerned more with cataloguing molecular alterations and finding associations, than with understanding fundamental principles using formal theory." Agreed.
journals.plos.org
The end of the genetic paradigm of cancer
Genome sequencing results and single-cell transcriptomics continue to produce findings that challenge the idea that cancer is purely a ‘genetic disease’. This Essay delves into cancer omics data that ...
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Chase Bolt @chasebolt.bsky.social · 11/09/2025
Charlie Kirk is dead by assassination. This political violence needs to stop. Things will only continue to get worse. I didn't like him but no one should be killed for their beliefs and speaking them aloud.
reuters.com
Conservative influencer Charlie Kirk shot dead at Utah event
Kirk, an activist and the founder of conservative student group Turning Point USA, played a key role in driving youth support for Trump in November.
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Chase Bolt @chasebolt.bsky.social · 10/09/2025
Drivers recruit pioneer factors that then "hop" to near-3D contacts to spread active chromatin context, producing a stable active landscape.
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Chase Bolt @chasebolt.bsky.social · 10/09/2025
Euchromatin hopping explains how some enhancers seem to initiate the formation of active regulatory landscapes, and why some/many enhancer deletions don't affect transcription quantity; there are driver and passenger enhancers. #chromatin #enhancers #generegulation
biorxiv.org
Enhancers mediate euchromatin hopping at chromatin contact points
Enhancer-mediated gene activation involves the recruitment of chromatin modifiers and RNA polymerase to target promoters, but it is unknown if enhancers influence chromatin beyond their target genes. ...
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Chase Bolt @chasebolt.bsky.social · 10/09/2025
As a former #evo-devo academic that moved to industry, I can say that people with evolutionary backgrounds are very employable in #biotech. In fact, they tend to do better than people trained in more narrow topics like cell biology. Folks doing genome evo, please come to industry. We need you.
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Chase Bolt @chasebolt.bsky.social · 09/09/2025
Oh that’s already taken by the Fed.
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Reposted by Chase Bolt
Developmental Biology @devbiol.bsky.social · 03/09/2025
#DBfeature Epithelial and mesenchymal compartments of the developing bladder and urethra display spatially distinct gene expression patterns by Baraiya, D. H., Kavya, T. T., Mandal, A., Chakraborty, S., Sathish, N., Francis, C. M. R., & Joseph tiom33.short.gy/DB520,155-170
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Chase Bolt @chasebolt.bsky.social · 18/04/2025
who will republicans blame for their problems when govt no longer exists?
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Chase Bolt @chasebolt.bsky.social · 04/03/2025
@smpowers.bsky.social I found you!
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Chase Bolt @chasebolt.bsky.social · 18/02/2025
Wouldn’t a sufficiently complex system stochastically produce regions of greater complexity?
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Chase Bolt @chasebolt.bsky.social · 06/02/2025
We cut off all foreign aid, stranded 10k people, and saved 1 #%$%#&$ % of the annual budget. Awesome. www.nytimes.com/2025/02/04/u...
nytimes.com
Trump Officials to Put Almost All U.S.A.I.D. Workers on Leave
Most employees overseas have been told to return to the U.S. Democrats have denounced recent moves to shrink the agency as an illegal power grab.
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Reposted by Chase Bolt
Jason Kelly @jasonrkelly.bsky.social · 20/11/2024
Made a biotech founders starter pack, DM me to be added! go.bsky.app/LWm8uPE
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Reposted by Chase Bolt
Jon Lim, FRCP PhD @drjonlim.bsky.social · 23/11/2024
🎨 In case anyone need… The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏! Check it out 👇 bioart.niaid.nih.gov
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Chase Bolt @chasebolt.bsky.social · 24/10/2024
Can someone please train some AI on large biological datasets like this, integrate with zfin database, and let me query it? #science #zfin www.biorxiv.org/content/10.1...
biorxiv.org
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