Marika Charalambous @charalambouslab.bsky.social · 09/02/2026Well done @geula.bsky.social for a lovely piece of work 010
Reposted by Marika CharalambousGeula Hanin @geula.bsky.social · 09/02/2026🎉 After a very long one (appropriately…), I’m excited to share work revealing an unexpected role for the epigenetic regulator ZFP57 - linking development, lactation, milk composition and lifelong health. Check it out: www.nature.com/articles/s41... #MammaryGlandBiology #DOHaDnature.comZFP57 is a regulator of postnatal growth and life-long health - Nature CommunicationsLactation is essential, but its genetic and epigenetic regulation is poorly understood. Here, Hanin et al. show that ZFP57 has an imprinting-independent role in controlling postnatal nutritional suppo... 4177
Marika Charalambous @charalambouslab.bsky.social · 02/02/2026Thanks @smamante.bsky.social and @brancolab.bsky.social for including us in this cool project! 020
Marika Charalambous @charalambouslab.bsky.social · 15/01/2026Overall, deletion of Dlk1 from the placental endothelial cells causes growth restriction and altered maternal metabolic adaptations to pregnancy. 000
Marika Charalambous @charalambouslab.bsky.social · 15/01/2026www.biorxiv.org/content/10.6...biorxiv.orgPlacental insufficiency causes fetal growth restriction in mice lacking Delta-like homologue 1Fetal growth restriction (FGR) affects between 3-7% of pregnancies, is associated with increased perinatal morbidity and mortality, and linked to failure of placental function. The placenta is the key... 110
Marika Charalambous @charalambouslab.bsky.social · 15/01/2026How do the mesodermally-derived cells contribute to placental function? In our new preprint we show that in the placental mesoderm the imprinted gene Dlk1 controls sensitivity to extrinsic signals via FOXO1. This regulates endothelial branching and hormone production. 100
Marika Charalambous @charalambouslab.bsky.social · 09/05/2025Thanks! Looking forward to catching up. 010
Reposted by Marika CharalambousBarral Lab @barrallab.bsky.social · 24/11/2024Our first 🦋 post! Very happy to share our latest paper just out in Cell Reports, exploring the crosstalk between immune and epithelial cells in the gut. Check it out! @vivianlilab.bsky.social @kingscollegelondon.bsky.social www.cell.com/cell-reports...cell.comIFN-γ-dependent regulation of intestinal epithelial homeostasis by NKT cellsThe crosstalk between immune and epithelial cells is vital to maintain intestinal homeostasis. Lebrusant-Fernandez et al. identify NKT cells in the small intestine as key regulators of epithelial biol... 520457