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Chad Brambley

@chadbrambley.bsky.social
244 followers 574 following 16 posts

Computational structural immunologist. Postdoc | Baker lab | Notre Dame | 🧬💻 Father, husband, leftist. Opinions my own.

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Reposted by Chad Brambley
Baker Lab @ Notre Dame @nd-bakerlab.bsky.social · 24/10/2025
Happy to have been part of this work with Karen Hastings and team at the Univ of Arizona quantifying the impact of structure on neoAg immunogenicity. Kudos to @chadbrambley.bsky.social and the others for their awesome work. Look for modeling to improve neoAg prediction! jitc.bmj.com/content/13/1...
jitc.bmj.com
Structural changes from wild-type define tumor-rejecting neoantigens
Background Challenges in predicting which neoantigens mediate tumor rejection limit the efficacy of neoantigen vaccines to treat cancers, especially for cancers with a high mutational burden like cuta...
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Chad Brambley @chadbrambley.bsky.social · 07/06/2025
Let's go home
Photograph of Phillip Dettmer's "Immune", taken with an airport jet bridge in the background.
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Chad Brambley @chadbrambley.bsky.social · 07/06/2025
I had a blast presenting our work on T cell mimotope discovery! A huge thank you to @epivax.bsky.social for hosting such a great meeting and inviting us to speak. I don't want to leave Rhode Island!
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Chad Brambley @chadbrambley.bsky.social · 07/03/2025
It was a cold and snowy one, but today we stood up for science! The fight is just beginning though, don't let them dismantle OUR research.
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Chad Brambley @chadbrambley.bsky.social · 05/02/2025
Ok, I've GOT to share this one. Genius might be a tad strong, but who am I to refute my boss haha
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Reposted by Chad Brambley
Diego del Alamo @delalamo.xyz · 21/01/2025
PDB viewer integration into Obsidian - I need this yesterday (source in alt text)
PDB viewer integration in obsidian to look at PDB structures within a markdown file

Source: https://www.linkedin.com/posts/leonardo-castorina_protein-activity-7285934811066593280-vdBd
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Reposted by Chad Brambley
Johnny 🫧 Cowlick @jefferycowlick.bsky.social · 17/01/2025
In a world of Kid Rocks and Carrie Underwoods, be a Woody Guthrie.
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Chad Brambley @chadbrambley.bsky.social · 10/01/2025
Can NOT believe we pulled it off in regulation! #GoIrish #NotreDame
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Chad Brambley @chadbrambley.bsky.social · 03/01/2025
Marcus Freeman might just be the smartest coach in the game. This was a fun one! #goirish 🍀
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Chad Brambley @chadbrambley.bsky.social · 28/12/2024
#immunosky Anyone else wake up to good news from grant Santa? This one's an F32 fellowship, to help take on TCR cross reactivity. Honored and excited to be working on this and grateful for the support!
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Reposted by Chad Brambley
nixCraft @cyberciti.biz · 02/12/2024
Student: I want to master #Linux, but I can’t grow a beard.  Master Foo: Once you master linux you become the beard. Upon hearing this, the student was enlightened.
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Reposted by Chad Brambley
bioRxivpreprint @biorxivpreprint.bsky.social · 29/11/2024
Design of high specificity binders for peptide-MHC-I complexes www.biorxiv.org/content/10.1101/202…
biorxiv.org
Design of high specificity binders for peptide-MHC-I complexes https://www.biorxiv.org/content/10.1101/2024.11.28.625793v1
Class I MHC molecules present peptides derived from intracellular antigens on the cell surface for i
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Reposted by Chad Brambley
Srijit Seal 🇺🇸🇬🇧🇩🇪🇯🇵🇮🇳 @srijitseal.com · 28/11/2024
Will save more time that asking ChatGPT!
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Reposted by Chad Brambley
Kris Laukens @krislaukens.bsky.social · 26/11/2024
🚀 Advancing T-cell receptor (TCR) research! We developed tcrBLOSUM, a specialized substitution matrix for sensitive alignment of distant epitope-specific TCRs. Find out how our findings expand TCR analysis: doi.org/10.1093/bib/... #Bioinformatics #Immunology #AIRR with @pmeysman.bsky.social
doi.org
tcrBLOSUM: an amino acid substitution matrix for sensitive alignment of distant epitope-specific TCRs
Abstract. Deciphering the specificity of T-cell receptor (TCR) repertoires is crucial for monitoring adaptive immune responses and developing targeted immu
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Chad Brambley @chadbrambley.bsky.social · 24/11/2024
I called both Wilson and Rutherford counties home during grad school. Not exactly surprised by my former neighbors, but I am both ashamed and embarrassed for them.
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Chad Brambley @chadbrambley.bsky.social · 23/11/2024
I think this will do nicely for my inaugural skeet. Thanks boss for the shout out! Eagerly (and cautiously) excited to get this thing funded. We have work to do! #immunosky
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