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Christina Bergonzo 🧬

@cbergonz.bsky.social
479 followers 194 following 25 posts

Research Chemist. Food motivated. Being a scientist/mom takes up all my time. She/her. #compchem Views are my own!

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Christina Bergonzo 🧬 @cbergonz.bsky.social · 04/01/2025
You have to put energy into a system to make it cyclize (form a ring). We found, using QM calculations, the amount of energy you need was proportional to how far apart the atoms start out.
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Christina Bergonzo 🧬 @cbergonz.bsky.social · 03/01/2025
My first presentation at a regional ACS meeting! April 2006!
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Reposted by Christina Bergonzo 🧬
They-Ra @xanindigo.bsky.social · 01/01/2025
new year’s resolution: be like sharks
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Christina Bergonzo 🧬 @cbergonz.bsky.social · 31/12/2024
My condolences Alex. I know how much he meant to you and the other Charmm developers. He’ll be missed by the compchem community at large.
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Christina Bergonzo 🧬 @cbergonz.bsky.social · 09/12/2024
😒 (🩶protein 🧡disulfides 💜glycans)
An intact antibodyA half exploded antibodyA fully exploded antibody
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Reposted by Christina Bergonzo 🧬
MwahahahahahadScientist @mads100tist.bsky.social · 09/12/2024
🧪
During lab meeting:
"I don't even have time to tell you how wrong you are"
Also during lab meeting:
"Actually, it's gonna bug me if I don't"
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Christina Bergonzo 🧬 @cbergonz.bsky.social · 05/12/2024
The thing about working with nucleic acids is that you’ll forget proteins can carry positive charge and need anions to neutralize 🤦🏻‍♀️
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Reposted by Christina Bergonzo 🧬
Proceedings of the National Academy of Sciences @pnas.org · 04/12/2024
Uranus and Neptune don’t have magnetic poles, according to data from NASA Voyager. The disordered magnetic field could be created by mantles with two liquid layers: one water layer and another carbon, nitrogen, and hydrogen layer. In PNAS: www.pnas.org/doi/10.1073/...
This picture of Neptune was produced from the last whole planet images taken through the green and orange filters on NASA's Voyager 2 narrow-angle camera. The images were taken at a range of 4.4 million miles from the planet, 4 days and 20 hours before closest approach. CREDIT: NASA
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Christina Bergonzo 🧬 @cbergonz.bsky.social · 03/12/2024
Using SIRAH to coarse grain my glycosylayed antibody! Hooray for (1) tutorials that work, and (2) my first foray into CG! Can I join the #glycotime club?
A close up of an IgG1 Fc domain glycan (blue) and its attachment point (green)An IgG1 antibody shown in secondary structure ribbon with coarse grained beads overlapping
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Christina Bergonzo 🧬 @cbergonz.bsky.social · 02/12/2024
Fleece lined tights! Wool and cashmere where possible - the latter is lightweight but warm
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Christina Bergonzo 🧬 @cbergonz.bsky.social · 27/11/2024
Messing around with pyrophosphates, hopefully adding them to modXNA in the near future. Then off to tackle termini mods. Then Thanksgiving prep begins. 👏🏻 checking 👏🏻those 👏🏻boxes
A picture of a Baltimore oriole from the national zoo
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Reposted by Christina Bergonzo 🧬
Alberto Perez @perezlab.bsky.social · 26/11/2024
We are looking for a #CompChem postdoc to implement MELD (Modeling Employing Limited Data) into the AMBER suite of programs and test new applications in integrative modeling. Work with @adrianroitberg.bsky.social and me at #UFChemistry! Apply here explore.jobs.ufl.edu/en-us/job/53...
explore.jobs.ufl.edu
University of Florida - Details - Post-Doctoral Associate in Computational Chemistry
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Reposted by Christina Bergonzo 🧬
Joe Yesselman @josephyesselman.bsky.social · 25/11/2024
🧬 Excited to share our new preprint! DMS chemical mapping, a key technique for studying RNA structure. Everyone assumes low DMS reactivity = Watson-Crick , high = non-WC. However, analyzing 7,500 RNA structures containing known 3D structures reveals it's not that simple. doi.org/10.1101/2024...
biorxiv.org
A quantitative framework for structural interpretation of DMS reactivity
Dimethyl sulfate (DMS) chemical mapping is widely used for probing RNA structure, with low reactivity interpreted as Watson-Crick (WC) base pairs and high reactivity as unpaired nucleotides. Despite i...
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Christina Bergonzo 🧬 @cbergonz.bsky.social · 23/11/2024
Zero slow down for the projects I use a fixed charge FF for. I need more sampling, not less. If something I’m investigating needs to include polarizeability, then the price is the price. Tagging @justinlemkulvt.bsky.social because this is something we discuss a lot!
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Christina Bergonzo 🧬 @cbergonz.bsky.social · 22/11/2024
Worm logo 4ever 💪
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Christina Bergonzo 🧬 @cbergonz.bsky.social · 22/11/2024
I read Dr. No: a novel for book club and loved it, James is on my TBR!! Check it out if you like spy thrillers :)
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Christina Bergonzo 🧬 @cbergonz.bsky.social · 22/11/2024
My students decided to try running MD with a 100 fs timestep today so we’re going to read the Ryckaert SHAKE paper
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Christina Bergonzo 🧬 @cbergonz.bsky.social · 21/11/2024
Updated ff94 atom types AND ran a 5k. The atom types were more exhausting 😩
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Christina Bergonzo 🧬 @cbergonz.bsky.social · 20/11/2024
upload.wikimedia.org/wikipedia/en...
Album cover from The Miseducation of Lauryn Hill
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Reposted by Christina Bergonzo 🧬
Guggenheim Collection @guggenheim.bsky.social · 19/11/2024
Several Circles by Vasily Kandinsky, 1926 botfrens.com/collections/212/conten…
Solomon R. Guggenheim Museum, New York
Solomon R. Guggenheim Founding Collection, By gift

© 2016 Artists Rights Society (ARS), New York/ADAGP, Paris
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Christina Bergonzo 🧬 @cbergonz.bsky.social · 19/11/2024
media.tenor.com
a close up of a white cat 's face with a sad look on its face .
ALT: a close up of a white cat 's face with a sad look on its face .
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Christina Bergonzo 🧬 @cbergonz.bsky.social · 19/11/2024
Looks great! There’s a yarn saying, “make a mistake to let your soul escape,” and I like to think it applies to both intentional and unintentional ones 😜
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Christina Bergonzo 🧬 @cbergonz.bsky.social · 15/11/2024
media.tenor.com
voldemort from harry potter is standing in front of a crowd and says he who shall not be named .
Alt: voldemort from harry potter is standing in front of a crowd and says he who shall not be named .
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Christina Bergonzo 🧬 @cbergonz.bsky.social · 15/11/2024
Each co-author on this paper individually has, in the past, spent days-weeks coming up with a single modification - annoying! Now we can get good parameters in minutes, that are built on top of the *very good* Amber nucleic acid force fields. ✌️🧬💻
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Christina Bergonzo 🧬 @cbergonz.bsky.social · 15/11/2024
I do molecular dynamics simulations of biopharmaceutical molecules, both protein and nucleic acid (RNA 4ever). Here’s a link to a recent project, modXNA, which parameterizes any combo of base/sugar/bb nucleic acid modification for an MD sim: pubs.acs.org/doi/10.1021/...
pubs.acs.org
modXNA: A Modular Approach to Parametrization of Modified Nucleic Acids for Use with Amber Force Fields
Modified nucleic acids have surged as a popular therapeutic route, emphasizing the importance of nucleic acid research in drug discovery and development. Beyond well-known RNA vaccines, antisense olig...
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Christina Bergonzo 🧬 @cbergonz.bsky.social · 15/11/2024
Hello! Im a research chemist working at NIST. This means my work supports US commerce through improving measurements of molecules. I work in a group of all types of structural biologists.
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Christina Bergonzo 🧬 @cbergonz.bsky.social · 13/11/2024
Im proud of my research, sure, but we WON THE PUMPKIN CARVING COMPETITION this year
Two pumpkins with bear faces painted to look like pandas. Celebrating the new pandas at the National Zoo!
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Christina Bergonzo 🧬 @cbergonz.bsky.social · 13/11/2024
I love a good pick up meeting.
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Christina Bergonzo 🧬 @cbergonz.bsky.social · 11/11/2024
Hahahahaha amazing, don’t we all ✌️
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Christina Bergonzo 🧬 @cbergonz.bsky.social · 11/11/2024
media.tenor.com
a lion standing on top of a rock with the words " the circle of life " below him
Alt: a lion standing on top of a rock with the words " the circle of life " below him
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Christina Bergonzo 🧬 @cbergonz.bsky.social · 09/11/2024
Hey!! So happy to see someone excited about our work!
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