pubs.acs.org
Alkane Dehydrogenation and H/D Exchange by a Cationic Pincer-Ir(III) Hydride: Cooperative C–H Addition and β-H Elimination Modes Induce Anomalous Selectivity
We report that the cationic iridium complex (iPrPCP)IrH+ catalyzes the transfer-dehydrogenation of alkanes to give alkenes and hydrogen isotope exchange (HIE) of alkanes and arenes. Contrary to established selectivity trends found for C–H activation by transition metal complexes, strained cycloalkanes, including cyclopentane, cycloheptane, and cyclooctane, undergo C–H addition much more readily than n-alkanes, which in turn are much more reactive than cyclohexane. Aromatic C–H bonds also undergo H/D exchange much less rapidly than those of the strained cycloalkanes, but much more favorably than cyclohexane. The order of reactivity toward dehydrogenation correlates qualitatively with the reaction thermodynamics, but the magnitude is much greater than can be explained by thermodynamics. Accordingly, the cycloalkenes corresponding to the strained cycloalkanes undergo hydrogenation much more readily than cyclohexene, despite the less favorable thermodynamics of such hydrogenations. Computational (DFT) studies allow rationalization of the origin of reactivity and the unusual selectivity. Specifically, the initial C–H addition is strongly assisted by β-agostic interactions, which are particularly favorable for the strained cycloalkanes. Subsequent to α-C–H addition, the H atom of the β-agostic C–H bond is transferred directly to the hydride ligand of (iPrPCP)IrH+ to give a dihydrogen ligand. The overall processes, C–H addition and β-H-transfer to hydride, are calculated to generally have minima on the IRC surface although not necessarily on the enthalpy or free energy surfaces; these minima are extremely shallow such that the 1,2-dehydrogenations are effectively concerted although asynchronous.
![A graphical abstract image showing the chemistry for the reduction of dinitrogen to ammonia with pincer-Mo complexes. The image shows that [MoIII]X2 undergoes N2 cleavage to form an MoIV complex with a triple bond to one nitrogen atom. This does not react further, unless protonation occurs followed by reacting with a hydrogen radical species. The introduction of H-atom donors then allows for the formation of ammonia.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:ztf52qr22zoguidj6uprs6az/bafkreigcirscyxaxzttbe5ixx6li4xtb5ytd2o5v34o5ivquke3w67qrsq)
