iiinova — where your digital self keeps evolving

𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 30/09/2026

How do we learn how treatment resistance emerges in pancreatic cancer? As Tyler Jacks told The New York Times today: by “doing science in patients.” Today Gina Kolata looks at the work bringing together leading cancer researchers to understand resistance to KRAS inhibition directly in patients.

nytimes.com

https://www.nytimes.com/2026/09/30/science/pancreatic-cancer-drug-daraxonrasib-ben-sasse-resistance.html?unlocked_article_code=1.FFE.0hEN.9Qv5Kb5hyncV&smid=url-share

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 24/09/2026

#WorldCancerResearchDay is a reminder that progress against cancer depends on sustained investment. At Break Through Cancer, we have committed over $137M since 2021 to research in acute myeloid leukemia, pancreatic cancer, ovarian cancer, glioblastoma, lung cancer, osteosarcoma and data science.

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 17/09/2026

What if a blood test could find signs of leukemia that standard tests miss? In a new PNAS study, researchers from our Eradicating Measurable Residual Disease in AML TeamLab tested an approach that searches cell-free DNA in the blood for up to 96 mutations specific to each patient’s leukemia.

pnas.org

A plasma-based DNA test for quantification of disease burden in acute myeloid leukemia patients undergoing bone marrow transplantation | PNAS

Allogeneic hematopoietic cell transplantation is the only curative option for many patients with acute myeloid leukemia (AML). In the current study...

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 15/07/2026

This weekend, Break Through Cancer Chief Science Officer @boehmjesse.bsky.social will deliver the opening keynote at the AACR Special Conference on Breaking Barriers in the Fight Against Rare Cancers.

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 01/07/2026

Functional precision medicine has enormous potential to improve how we match the right cancer therapies to the right patients. This week, our Chief Scientific Officer @boehmjesse.bsky.social is participating in the National Cancer Institute's Precision in Practice workshop

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Reposted by 𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿

The Lustgarten Foundation @lustgarten.org · 29/06/2026

What's next for KRAS-targeted therapies? We're investing $16M with @break-cancer.bsky.social & the Cinelli Family Foundation to unite six leading institutions to find out! 💜 Read the FULL release: lfdn.org/KRAS_2

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 29/06/2026

At an exciting moment for pancreatic cancer, Break Through Cancer, and @lustgarten.org, with support from the Cinelli Family Foundation are investing $16 million to help define what's next for this deadly disease.

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 01/06/2026

Minimal residual disease remains one of the biggest challenges in #OvarianCancer. At #ASCO2026, Dr Helen Clark from our Targeting MRD in Ovarian Cancer TeamLab presents work evaluating how ctDNA may enhance detection of high-risk minimal residual disease.

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 31/05/2026

Important moment for #PancreaticCancer at today's #ASCO2026 plenary Dr. Brian Wolpin presents final analysis from the Phase 3 RASolute 302 study evaluating daraxonrasib in previously treated metastatic PDAC. Encouraging to see these advances from RevMed to improve outcomes for patients.

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 30/05/2026

Few targets have required more persistence than #KRAS. At #ASCO2026, the @AACR / @ASCO joint session, The KRAS Journey—Perseverance Pays Off, brings together leaders from across the field to reflect on decades of discovery and the advances now reaching patients.

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 29/05/2026

. #ASCO2026 kicks off today. It’s always exciting when the cancer research community comes together to share new science, challenge ideas, and learn from one another. We look forward to following the advances emerging from this year’s meeting.

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 26/05/2026

This week, the Accelerating #Glioblastoma Therapies Through Serial Biopsies TeamLab are meeting in person to dive into the data—from clinical outcomes, tumor evolution, immune response, spatial biology, and metabolomics—to shape publications, moving these insights into the #CancerResearch community.

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 24/04/2026

An energizing week at #AACR26 for 𝖡𝗋𝖾𝖺𝗄 𝘛𝘩𝘳𝘰𝘶𝘨𝘩 𝖢𝖺𝗇𝖼𝖾𝗋. We’re proud to support this community and the science they are driving forward. For our AACR recap and other updates, join our newsletter: breakthroughcancer.org/2026/04/subs...

breakthroughcancer.org

Subscribe for updates - Break Through Cancer

Explore Break Through Cancer’s 2025 Year in Review highlighting clinical trials, breakthrough research, data science innovation, and radical collaboration across glioblastoma, AML, ovarian,…

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 22/04/2026

The final day of #AACR2026 posters to catch. From #Glioblastoma oncolytic virus therapy (Abstract 7743) to #PancreaticCancer RAS biology (Abstract7330) and large-scale #CancerGenomics (Abstract 7274), these BTC posters highlight how deeper understanding is shaping precise cancer treatment.

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 22/04/2026

.#LiquidBiopsy is changing how we think about and quantify MRD. At #AACR2026, Valsamo Anagnostou presents advances in ctDNA approaches to detect, characterize, and address MRD, an area with major implications for earlier intervention and more precise cancer care. ADT04 |Ballroom 6A | 10.45am

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 21/04/2026

Personalized medicine is the future for ALK+ #LungCancer and data science is how we get there. Exciting work from our collaborators at @mdanderson.bsky.social on digital twins using #AI to model patient outcomes & guide treatment decicions. MS.BC02.01 |Ballroom 20 | 3.05pm

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 21/04/2026

In the Late Breaking session (LBMS01) Revolution Medicines highlights progress in RAS(ON) inhibition. It is an exciting time for RAS-targeted therapy in #PancreaticCancer LBM201 | Room 5 Upper Level | 2.30pm

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 21/04/2026

. #PancreaticCancer research is at a turning point with major advances in treatments, biology, and early interception. Today PIs across our PDAC TeamLabs, Shubham Pant, Will Freed-Pastor, and @anirbanmaitra.bsky.social present on therapeutic advances, cryptic antigens, and early detection. AOS10

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 20/04/2026

Exciting data from the our Accelerating GBM Therapies Through Serial Biopsies TeamLab at #AACR26: New #AI-driven approaches are advancing how we analyze imaging in #Glioblastoma to support precise, scalable tumor characterization from radiology data. PO.BCS02.04 | 2-5pm

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 20/04/2026

Understanding clonal hematopoiesis could unlock #EarlyDetection and prevention of AML. Dr. Benjamin Ebert of @danafarber.bsky.social and a leader in our AML TeamLab presents on CHIP, inflammation, and AML developments this morning at #AACR26 SY10 | Room 30 Upper Level | 11.10

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 20/04/2026

Understanding #Glioblastoma means mapping tumor architecture in high definition. At #AACR26, TeamLab PI Mario Suva presents on spatial analysis of GBM, advancing how we map tumor architecture, heterogeneity, and the biology that shapes treatment response. AOS04 | Room 15 Mezz Level | 10.15am

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 20/04/2026

The biggest opportunities in #OvarianCancer are in #EarlyDetection and #Prevention. At #AACR26, Drs Rebecca Stone, Angela Belcher, and @rdrapkin8-penn.bsky.social present a field-shaping session spanning surgical prevention to, imaging that detects tubal precursors, and the pre-cancer atlas AOS09

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 20/04/2026

AI can reshape how we study cancer biology - this is the topic of today's plenary at #AACR26 SAB member @bowang87.bsky.social speaks to foundation models that can reason across complex biological systems and where #AI in #Cancer Research is headed

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 19/04/2026

Sunday at #AACR26 and the science continues. Work from our GBM TeamLab highlights a key challenge in #Glioblastoma: biomarker signatures vary across patients—and even within the same tumor over time (abstract 1055) Looking forward to bringing our community together this evening at the BTC Social

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 18/04/2026

Residual disease is in focus at the opening #AACR2026 plenary Aaron Hata @mgbresearch.bsky.social will highlight work from the PoweRD 2 Cure ALK+ Lung Cancer TeamLab on MRD in lung cancer—underscoring how collaborative, preclinical science is shaping our understanding of MRD. #AACR26

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 18/04/2026

Today at #AACR2026, our SAB member Dr Robert Winn highlighted patient-centered approaches to bringing trials closer to the communities they serve. Dr. Winn echoes our goal to ensure the science we support drives better outcomes for all patients.

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 18/04/2026

Exciting work coming out of the 𝖡𝗋𝖾𝖺𝗄 𝘛𝘩𝘳𝘰𝘶𝘨𝘩 𝖢𝖺𝗇𝖼𝖾𝗋 community over the coming days at #AACR2026. From work advancing earlier detection, deeper understanding of tumor biology, to more precise approaches to treatment. Sure to be a great meeting - @theaacr.bsky.social

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 15/04/2026

Congratulations to the Revolution Medicines team on the important results from the RASolute302 Phase 3 clinical study of daraxonrasib in advanced #PancreaticCancer. As progress accelerates in targeting KRAS-driven tumors, the next step is understanding the effects of these therapies in patients.

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 15/04/2026

Congratulations to @boehmjesse.bsky.social, our Chief Science Officer, and @broadinstitute.org's DepMap team on their 2026 @theaacr.bsky.social Scientific Achievement Award. This team is honored for systematically mapping genetic dependencies across cancer cells to uncover specific vulnerabilities

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 07/04/2026

Congratulations to members 𝖡𝗋𝖾𝖺𝗄 𝘛𝘩𝘳𝘰𝘶𝘨𝘩 𝖢𝖺𝗇𝖼𝖾𝗋 community members named as Fellows of the @theaacr.bsky.social Academy Class of 2026! Cory Abate-Shen, Christina Curtis, Ross Levine (@rosslevinemd.bsky.social), William (Bill) Nelson, Alice Shaw, & Matthew Vander Heiden. www.aacr.org/about-the-aa...

aacr.org

AACR Announces Fellows of the AACR Academy Class of 2026

The American Association for Cancer Research (AACR) today announced its newly elected 2026 class of Fellows of the AACR Academy.

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 01/04/2026

𝗘𝗮𝗿𝗹𝘆 𝗱𝗲𝘁𝗲𝗰𝘁𝗶𝗼𝗻 𝗶𝘀 𝗼𝗻𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗯𝗶𝗴𝗴𝗲𝘀𝘁 𝗼𝗽𝗽𝗼𝗿𝘁𝘂𝗻𝗶𝘁𝗶𝗲𝘀 𝘁𝗼 𝗰𝗵𝗮𝗻𝗴𝗲 𝗰𝗮𝗻𝗰𝗲𝗿 𝗼𝘂𝘁𝗰𝗼𝗺𝗲𝘀. This year we committed $2M in partnership with @themarkfdn.bsky.social, @theaacr.bsky.social, @lustgarten.org, and @tinaswish.bsky.social to support the development of new approaches to detect deadly cancers earlier.

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 13/03/2026

𝖡𝗋𝖾𝖺𝗄 𝘛𝘩𝘳𝘰𝘶𝘨𝘩 𝖢𝖺𝗇𝖼𝖾𝗋 and our president Tyler Jacks are featured in @cancerletter.com today. The story highlights our model of Radical Collaboration™ and how we’re aligning institutions and scientists to accelerate progress against the deadliest cancers. cancerletter.com/conversation...

cancerletter.com

Break Through Cancer’s Tyler Jacks: “We’ve created a new operating model for collaborative cancer research.” - The Cancer Letter

Five years ago, Tyler Jacks took on a new challenge, becoming president of Break Through Cancer, a foundation that has pledged to spend at least $500 million to support research projects across top ti...

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𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 @break-cancer.bsky.social · 25/02/2026

As we mark five years of Break Through Cancer, we’re posting here for the first time! Five years ago, we asked: What would cancer research look like if collaboration was built into the design? #RadicalCollaboration™ is our answer. These numbers reflect the scale

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