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Bose Lab Sheffield

@bose-lab.bsky.social
104 followers 71 following 1 posts

Working on mechanistic enhancer biology at the University of Sheffield, UK. Part of Sheffield Nucleic Acids Institute and Centre for Single Molecule Biology See also @danbose.bsky.social

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Bose Lab Sheffield @bose-lab.bsky.social · 29/01/2025
Exciting new packages!! Very cool ❄️ to see the new microscope (JEMma) added to the cryoEM facility to keep @AvaArctica company @sheffielduni.bsky.social @mcb-sheffield.bsky.social! (Ok, it does look a little bit like a washing machine!) lookout for more details soon!
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Reposted by Bose Lab Sheffield
Dan Bose @danbose.bsky.social · 20/12/2024
Amazing #RNA structural ensembles! Really highlights how important #singlemolecule approaches are for finding mechanism in sustems and models that move! www.nature.com/articles/s41...
nature.com
The conformational space of RNase P RNA in solution - Nature
Using a deep neural network and statistical analyses of atomic force microscopy images of individual RNA molecules enables the mapping of RNA conformational space in solution.
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Dan Bose @danbose.bsky.social · 08/11/2024
Posting this awesome work from the summer led by Katie in our team- currently undergoing some exciting new upgrades :) www.biorxiv.org/content/10.1...
biorxiv.org
Cooperation between Intrinsically Disordered Regions regulates CBP condensate behaviour
Creb binding protein (CBP) and EP300 (p300) are transcription coactivators that bind at cis -regulatory elements and regulate gene expression in multicellular organisms. They contain large intrinsical...
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Duncan Sproul @sproullab.bsky.social · 01/11/2024
With some help from @raduzabet.bsky.social, I've created a starter pack of researchers working on #Epigenetics, Chromatin and Gene Regulation who are active on here: go.bsky.app/TKp9YAn I've likely missed many people so let me know if you want to be added. Similarly if you would like to be removed.
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Dan Bose @danbose.bsky.social · 13/11/2024
Fantastic, well articulated review reconciling how regulatory complexes at the molecular level function in the context of transcriptional condensates.
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Reposted by Bose Lab Sheffield
adam grieve @adamgrieve.bsky.social · 15/11/2024
Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c
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Danny IncaRNAto @incarnatolab.bsky.social · 15/11/2024
Fellow #RNA lovers, please repost 🙏: 2 ERC-funded Post-doc positions are available in our lab to investigate #RNA structural ensemble and their dynamics in living cells. Application link: t.co/pYJ3H3j705
t.co
https://www.rug.nl/about-ug/work-with-us/job-opportunities/?details=00347-02S000B06P
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Dan Bose @danbose.bsky.social · 15/11/2024
Bringing the lab account over too!! Check us out at @bose-lab.bsky.social 🧬🥼🧪⚗️🔬🪴
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