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Theodore (Teddy) Fisher @borderbiologist.bsky.social · 05/08/2026

I'm particularly excited about our findings that go beyond descriptive marker expression by functionally testing astrocyte antigen-dependent T cell responses and their downstream effects. Looking forward to seeing the evolution of this study, and I'd love to hear your thoughts and feedback!

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Theodore (Teddy) Fisher @borderbiologist.bsky.social · 05/08/2026

-Human iPSC-derived astrocytes similarly upregulate antigen-presentation-associated machinery following inflammatory stimulation, suggesting these responses are conserved across species.

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Theodore (Teddy) Fisher @borderbiologist.bsky.social · 05/08/2026

-In vitro, cytokine-stimulated astrocytes express MHC-II, costimulatory molecules, and T cell-recruiting chemokines, and can support antigen-dependent restimulation and expansion of previously activated CD4+ T cells.

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Theodore (Teddy) Fisher @borderbiologist.bsky.social · 05/08/2026

-MHC-II⁺ astrocytes emerge at neuroimmune interfaces across multiple mouse models of neuroinflammation (sepsis, EAE, infection) and are also present in human neurological disease tissue (MS, AD).

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Theodore (Teddy) Fisher @borderbiologist.bsky.social · 05/08/2026

Some of our key findings: -We identified an interferon-responsive astrocyte population enriched for antigen-presentation genes following peripheral immune challenge.

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Reposted by Theodore (Teddy) Fisher

Cell Press @cellpress.bsky.social · 18/11/2025

"Defining the molecular identity and morphology of glia limitans superficialis astrocytes in vertebrates" dlvr.it/TPKJSH @liddelowsa.bsky.social @philiphasel.bsky.social & colleagues @cp-cellreports.bsky.social #SfN2025

Defining the molecular identity and morphology of glia limitans superficialis astrocytes in vertebrates, Cell Reports

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Reposted by Theodore (Teddy) Fisher

Shane Liddelow @liddelowsa.bsky.social · 17/11/2025

#SfN25 #SocietyForGlia #Astrocytes Monday is a BUSY day - see you all out there! (apologies for anyone's presentation I missed - please comment below with details)

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Reposted by Theodore (Teddy) Fisher

NYULH Neuroscience @nyulhneuro.bsky.social · 16/11/2025

Great to see @borderbiologist.bsky.social’s poster on antigen presenting reactive astrocytes ⭐️ #SfN25

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Reposted by Theodore (Teddy) Fisher

Zoe McElligott @nanopharmnc.bsky.social · 22/01/2025

I just reached out to my senators about the NIH situation. If you need to find out how much impact NIH has in your state in terms of dollars in and their economic impact here's a link: www.unitedformedicalresearch.org/nih-in-your-...

unitedformedicalresearch.org

NIH In Your State - United For Medical Research

Select a state on the map to see the impact of NIH funding across America.

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Reposted by Theodore (Teddy) Fisher

Alyson Smith @pedsaly.bsky.social · 23/01/2025

The antidote for despair is action ❤️ * Dial (202) 224-3121 * Enter zip code * Leave voicemail * Say “My name is ___, I’m a constituent in [town]. (If clinician/scientist, say so) “The NIH freeze harms research and patients and must be lifted immediately.” Be brief. Staffers tally all calls. Go! ✅

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Reposted by Theodore (Teddy) Fisher

Samuel Marsh Ph.D. @samuelmarsh.bsky.social · 03/12/2024

Big day for single cell and neuroscience. Trio of single cell perspective pieces discussing applications, opportunities, challenges, and validation of single cell and spatial genomics in neuroscience are out now in Nature Neuroscience. Links in thread below.👇 1/n

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Theodore (Teddy) Fisher @borderbiologist.bsky.social · 21/11/2024

This is especially relevant given reactive astrocyte localization and abundance! Thanks for pointing out

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Theodore (Teddy) Fisher @borderbiologist.bsky.social · 19/11/2024

Grateful to be a part of this talented group of #glia biologists. Go follow!

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