Reposted by Alessio QuaresimaMaciej Kania @kaniamaciej.bsky.social · 25/09/2026Train your model on a task, or fit it to biological data? And once it's optimized, what does it tell us about the brain? 🧠 In our #BernsteinConference satellite workshop, we'll discuss these questions through the lenses of different optimization methods. Check it out in Room 3.104! 🤓😉 44320
Reposted by Alessio QuaresimaNicole Rust @nicolecrust.bsky.social · 11/03/2026Ruffling some feathers, it's fascinating to ask: What forces drive this plot? To what degree is our community targeting important challenges and creating impactful solutions vs caught up in the inertia of curiosity and opportunity? For instance, ... /1 4113
Alessio Quaresima @bluedebris.bsky.social · 21/01/2026I mean, the only good thing about current international political affairs is that if they go all in on cannons maybe they stop building these dumbass tech 010
Alessio Quaresima @bluedebris.bsky.social · 09/01/2026Considering they re popular among tech bros it could be good news 010
Alessio Quaresima @bluedebris.bsky.social · 14/12/2025Okok, the comparison works only in ML. We can't look up the past inputs to make predictions about the future. Is reservoir just a possible memory implementation? 110
Alessio Quaresima @bluedebris.bsky.social · 14/12/2025RC is indeed quite a cool computational framework, however it has shortcomings. 1. Where is the supervised decoder? 2. How do you motivate learning? (But see recent @bconfavreux.bsky.social work) I dug the rabbit hole and found this: www.nature.com/articles/s41... You can do RC without network 🤣nature.comNext generation reservoir computing - Nature CommunicationsReservoir computers are artificial neural networks that can be trained on small data sets, but require large random matrices and numerous metaparameters. The authors propose an improved reservoir comp... 130
Reposted by Alessio QuaresimaNeurospeech Team @neurospeech.bsky.social · 15/10/2025Our review "Neuro-oscillatory models of cortical speech processing", authored by Olesia Dogonasheva, has finally been published. Check it below ⬇️ #compneuro #neuroskyence #EEGsciencedirect.comNeuro-oscillatory models of cortical speech processingIn this review, we examine computational models that explore the role of neural oscillations in speech perception, spanning from early auditory proces… 082
Alessio Quaresima @bluedebris.bsky.social · 14/10/2025When you are debugging and this song comes up three times on your playlist, you can't help but wonder, "Why do they scream OREGANO??" link.deezer.com/s/31jU4pHH39...link.deezer.comOnly God KnowsYoung Fathers - album - 2017 - 1 song 000
Alessio Quaresima @bluedebris.bsky.social · 10/10/2025Sure, in the end, everything is an RNN ;) Mongillo's model indeed requires pre-formed attractors. However, that model opens up to other sub-threshold memory mechanisms that can maintain STM when LTMs are not present, yet. 100
Alessio Quaresima @bluedebris.bsky.social · 10/10/2025So maybe if an RNN has memory that scales up with the size, it is a better model of activated LTM rather than of STM. No? 110
Alessio Quaresima @bluedebris.bsky.social · 09/10/20254-7 *new* items! If you learn to use a retrieval structure, you go pretty big - as all those crazy memorists do! online WM of novel items require variable binding, and I doubt you can get it in RNNs. Check this out for a cogsci perspective pmc.ncbi.nlm.nih.gov/articles/PMC...pmc.ncbi.nlm.nih.govShort-Term Memory and Long-Term Memory are Still DifferentA commonly expressed view is that short-term memory (STM) is nothing more than activated long-term memory. If true, this would overturn a central tenet of cognitive psychology—the idea that there are ... 100
Alessio Quaresima @bluedebris.bsky.social · 09/10/2025IMHO. Because it does not have "memory slots" ready for it, if it has memory slots, it lacks the machinery to convert them back into sensory representations. But you're the RNN expert, if you say it, I believe you ;) 100
Alessio Quaresima @bluedebris.bsky.social · 09/10/2025Can it distinguish a shape it saw once from one it never saw? And despite visual distractors? 100
Alessio Quaresima @bluedebris.bsky.social · 09/10/2025Maybe we do have five stable attractors in pfc and use them to re-cue sensory perceptions. But we need to be clear about active/silent interactions to move forward in this direction. 100
Alessio Quaresima @bluedebris.bsky.social · 09/10/2025True. However, the attractor `iff` pers. activity is the case only if we consider the firing rate as the only variable at play in the brain. Any cognitive theory of WM requires the allocation of new items on the fly. Can we build attractors through single-shot learning? Or we repurpose the same? 200
Alessio Quaresima @bluedebris.bsky.social · 09/10/2025True! However, we have learned about long-term memory formation and maintenance from snails. Divergent evolutionary paths can yet implement similar computational mechanisms. IMHO, recurrent activity is not as prominent in monkey's PFC as in fruitfly MB, but the comparison holds. 010
Alessio Quaresima @bluedebris.bsky.social · 07/10/2025If you're still updating the starter pack, add me in ;) 100
Alessio Quaresima @bluedebris.bsky.social · 07/10/2025I want to be the guy on the left. libera nos domine de AI 000
Alessio Quaresima @bluedebris.bsky.social · 07/10/2025In the image I see a mid age person with a wise face and - probably - mastering a complex software Vs a youngster with a naive smile clicking buttons on an anonymous interface while the world burns 100
Alessio Quaresima @bluedebris.bsky.social · 01/10/2025At #BernsteinConference heated debate on WM mechanisms. I love that this is still far to be settled! trained RNNs from A.Compte aligns with fruitfly direction WM data from K.Nagel: it is persistent. Large scale recording in macaque V1 in T.Moore Lab: it is not. #neuroskyence what's your take? 1130
Alessio Quaresima @bluedebris.bsky.social · 30/09/2025And concluding with a beautiful thermodynamics of learning: The correct learning rate depends on the noise of the training set (sigma eta)! 130
Alessio Quaresima @bluedebris.bsky.social · 30/09/2025And reminding the great neuroscientist **and middle east pacifist** Daniel Amit! 130
Alessio Quaresima @bluedebris.bsky.social · 30/09/2025So cool to walk from Ising models to recurrent network dynamics at the Braitenberg prize ceremony of Sara Solla! At #bernstein conference #compneurosky 1142
Alessio Quaresima @bluedebris.bsky.social · 26/09/2025The library strikes a balance between creating new models and composing them in fairly complex networks. If you would like some specific feat and cannot achieve it, just contact me and we'll find a way together! 030
Alessio Quaresima @bluedebris.bsky.social · 26/09/2025Hey #neuroskyence and #compneurosky I recently released this #Julia library for simulating Spiking Neural Networks! bit.ly/4mAbRly As with everything in Julia, it is fast, elegant, and compact! Check out the documentation and the tutorials to get an idea!bit.lySpikingNeuralNetworks.jl Documentation · Julia SpikingNeuralNetworksDocumentation for Julia SpikingNeuralNetworks. 1131
Alessio Quaresima @bluedebris.bsky.social · 17/09/2025Where do they get all this money to infest our market anyway??? 000
Alessio Quaresima @bluedebris.bsky.social · 14/09/2025Hey #neuroskyence #compneurosky I made this interactive tool for showing the phase planes of 2D neuron models to studs! Have fun :) github.com/JuliaSNN/Com... 1124
Alessio Quaresima @bluedebris.bsky.social · 12/09/2025Thank you! I wanted to feel better this mornin 🤣 000
Reposted by Alessio QuaresimaPessoaBrain @pessoabrain.bsky.social · 09/09/2025𝗕𝗿𝗮𝗶𝗻-𝘄𝗶𝗱𝗲 𝗰𝗼𝗺𝗽𝘂𝘁𝗮𝘁𝗶𝗼𝗻𝘀 Spatially distributed and regionally unbound cellular resolution brain-wide processing loops in mice 𝗕𝗿𝗮𝗶𝗻 𝗿𝗲𝗴𝗶𝗼𝗻𝘀 𝗼𝗿 𝗱𝘆𝗻𝗮𝗺𝗶𝗰 𝘁𝗵𝗿𝗲𝗮𝗱𝘀? Dynamical processing winding through most brain regions. Looks like a must read. www.biorxiv.org/content/10.1... #neuroskyencebiorxiv.orgSpatially distributed and regionally unbound cellular resolution brain-wide processing loops in miceUntil recently, it has been possible to examine activity in the brain globally through regional averaging or locally at cellular resolution. These studies characterized regions as functionally homogen... 116124
Reposted by Alessio QuaresimaNature Portfolio @natureportfolio.nature.com · 09/09/2025The International Brain Laboratory presents in Nature a brain-wide electrophysiological map that represents a resource for understanding how computations distributed across and within brain areas drive behaviour. go.nature.com/4nnnmhg 🧪 🧠📈 22815
Reposted by Alessio QuaresimaNeurofrontiers @neuro-frontiers.bsky.social · 22/08/2025Progesterone is another sex hormone best known for its effects on the female reproductive system. Similar to estrogens, however, it’s becoming increasingly clearer that progesterone impacts many more systems in the body, both in females and in males. #neuroskyence #skyence #hormonesneurofrontiers.blogProgesterone in the brain - NeurofrontiersProgesterone is a sex hormone with broad effects beyond the reproductive system, in particular in the brain. 182
Alessio Quaresima @bluedebris.bsky.social · 15/07/2025There are examples of different IPSP dependently on the location of the afferent on the postsynaptic neuron. That would do? 000
Alessio Quaresima @bluedebris.bsky.social · 05/07/2025I don't understand, whats the problem if people use chatgpt to write part of their text? Like, the write the prompt with the info in bullet points, and ask for a text. Is this any type of scientific fraud? 100
Alessio Quaresima @bluedebris.bsky.social · 04/07/2025What a time when you could title your paper like this! 000
Alessio Quaresima @bluedebris.bsky.social · 04/07/2025@imbizo.bsky.social Hey! Great school! Are teaching assistants applications still open? 000
Reposted by Alessio QuaresimaMax Planck Institute for Psycholinguistics @mpi-nl.bsky.social · 30/06/2025Nonlinear dendritic integration supports Up-Down states in single neurons. Paper by @bluedebris.bsky.social & al. With Hartmut Fitz, Peter Hagoort doi.org/10.1523/JNEUROSCI.1701-24.2025 Paper: tinyurl.com/34pptvv5doi.orgNonlinear Dendritic Integration Supports Up–Down States in Single NeuronsChanges in the activity profile of cortical neurons are due to effects at the scale of local and long-range networks. Accordingly, abrupt transitions in the state of cortical neurons—a phenomenon know... 021
Reposted by Alessio QuaresimaJames Vornov @jjvornov.bsky.social · 24/06/2025The neuroscience tale of how purple, really magenta, is a synthetic color not found on the spectrum. We don't perceive the environment, but become aware of the brain's processing of color. I conclude, Kant was right, there is a priori knowledge. But he never realized it was neuronal. #neuroskyenceopen.substack.comIf Purple isn’t real, then what is?Let’s talk epistemology. Actually, let’s have magenta and cyan bid farewell to epistemology altogether 072
Reposted by Alessio QuaresimaPenn NeuroKnow 🧠 @pennneuroknow.bsky.social · 10/06/2025How does climate change impact the brain? Spoiler alert: it’s not looking good.. Check out this week's piece where @pennngg.bsky.social student Margaret Gardner dives into this chilling topic: pennneuroknow.com/2025/06/10/c... #neuroskyence #PsychSciSky #SciCommpennneuroknow.comChanging Climate, Changing BrainsHow does climate change impact the brain? Spoiler alert: it’s not good 078
Alessio Quaresima @bluedebris.bsky.social · 23/05/2025It feels like a Harry Potter book... www.nytimes.com/2025/05/22/u...nytimes.comTrump Administration Says It Is Halting Harvard’s Ability to Enroll International Students 000
Reposted by Alessio QuaresimaDirk Gütlin @gutlin.bsky.social · 19/05/2025Dopaminergic action prediction errors serve as a value-free teaching signal www.nature.com/articles/s41...nature.comDopaminergic action prediction errors serve as a value-free teaching signal - NatureDopaminergic action prediction error signals are used by mice as a value-free teaching signal to reinforce stable sound–action associations in the tail of the striatum. 093
Alessio Quaresima @bluedebris.bsky.social · 19/05/2025I understand, but don't these apply to attractors theory too? I mean, I dunno much about PVT, just saying attractor states are a powerful abstraction and can account for permanent states on top of a biological, changing substrate 100
Alessio Quaresima @bluedebris.bsky.social · 18/05/2025what about attractor states?? Even if not still, they are permanent, self sustained states. They can also exist on longer timescales of working memory. Any memory is an example that such states exist... 130