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Ben Kellman

@bkell1123.bsky.social
1.3K followers 1.4K following 26 posts

Bioinformatics PhD @ UCSD | Research Fellow @ Ragon Institute at MGH, MIT, and Harvard | Founder glycan metabolism, gene expression, NGS, pathology (he/him) Boston MA, San Diego CA, Rochester NY, NYC NY

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Ben Kellman @bkell1123.bsky.social · 06/05/2025
What is the most appropriate platform for roasting a #bioinformatics colleague? You simply put them on BLAST
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Ben Kellman @bkell1123.bsky.social · 12/04/2025
Important work! Generally we either think about specialized glycan binding proteins (lectins) or we don't think about glycans. Canner et al help us see the massive world proteins, 35-40%, that also bind glycans! Thanks Sam for bringing glycan-protein interactions into focus!
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Ben Kellman @bkell1123.bsky.social · 18/11/2024
Sorry I don't run the list. Usually, it's the first person on the list.
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Reposted by Ben Kellman
Richard Ferro, MD MSc @richferro.com · 18/11/2024
#Medsky update: I've added label support to the following feeds: Family Medicine: bsky.app/profile/meds... Cardiology: bsky.app/profile/meds... Int Medicine: bsky.app/profile/meds... Nephrology: bsky.app/profile/meds... Gastro: bsky.app/profile/meds... Rheum: bsky.app/profile/meds...
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Reposted by Ben Kellman
Anshul Kundaje @anshulkundaje.bsky.social · 18/11/2024
Boltz-1: Open source (MIT license) protein + PPI + PLI structure prediction method performs on par with AlphaFold3 by Gabriel Corso, Barzilay et al. & Genesis Therapeutics Blog-post jclinic.mit.edu/boltz-1/ Technical report: t.co/px0spnTA0S Model and code: github.com/jwohlwend/boltz
jclinic.mit.edu
Introducing Boltz-1: Democratizing Biomolecular Interaction Modeling – MIT Jameel Clinic
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Ben Kellman @bkell1123.bsky.social · 18/11/2024
Important numbers to know for the difficult years ahead. Also worth asking if the "next dollar" will yield similar returns. How much more would we need to invest in research to see less than a 250% return?
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Ben Kellman @bkell1123.bsky.social · 17/11/2024
Cancer biology go.bsky.app/7xTwrrn
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Ben Kellman @bkell1123.bsky.social · 17/11/2024
5/5 Manuscript two functionalizes the discovered glycan-genetic encoding to an easy-to-use and accurate neural network, the INterloping Saccharide Neural Network Extrapolation (InSaNNe), for predicting glycans on the membranes www.biorxiv.org/content/10.1...
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Ben Kellman @bkell1123.bsky.social · 17/11/2024
4/5 Manuscript one details the discovery of the “GlycoTemplate,” the protein structural constraints on glycan biosynthesis. www.biorxiv.org/content/10.1...
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Ben Kellman @bkell1123.bsky.social · 17/11/2024
3/5 Glycosylation, like all biosynthesis, depends on environmental conditions. However, in contrast to non-templated glycan biosynthesis, we have discovered a comprehensive mapping of protein structure to specific glycosylation events.
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Ben Kellman @bkell1123.bsky.social · 17/11/2024
2/5 Glycosylation is classically considered to be non-templated. Classically, glycans are determined by the cellular environment and NOT the genome.
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Ben Kellman @bkell1123.bsky.social · 17/11/2024
Thanks and yes of course, I'll pass his name along there.
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Ben Kellman @bkell1123.bsky.social · 17/11/2024
Single cell go.bsky.app/GmS1cH
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Ben Kellman @bkell1123.bsky.social · 17/11/2024
Hi Rod, I'm a new immunoligist at Ragon with some published work in vaccine and humoral immunity. Would you consider adding me?
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Ben Kellman @bkell1123.bsky.social · 17/11/2024
Love your list! Im not a card carrying structural bio person but i think my main project is relevant to the space (predicting glycans from protein structure). Would you consider adding me and/or my former pi (bsky.app/profile/nate...) to your list?
bsky.app
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Ben Kellman @bkell1123.bsky.social · 17/11/2024
Love your list! Im not a card carrying structural bio person but i think my main project is relevant to the space (predicting glycans from protein structure). Would you consider adding me and my former pi (bsky.app/profile/nate...) to your list?
bsky.app
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Ben Kellman @bkell1123.bsky.social · 17/11/2024
More structural bio bsky.app/starter-pack... bsky.app/starter-pack...
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Ben Kellman @bkell1123.bsky.social · 17/11/2024
AI blueskydirectory.com/starter-pack...
blueskydirectory.com
Data Science Ai Ml Infrastructure - Bluesky Directory
A curated collection of all things relating to the Blue Sky social media platform.
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Ben Kellman @bkell1123.bsky.social · 17/11/2024
Immunology bsky.app/starter-pack... bsky.app/starter-pack... bsky.app/starter-pack... bsky.app/starter-pack... bsky.app/starter-pack...
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Ben Kellman @bkell1123.bsky.social · 17/11/2024
Biostatistics bsky.app/starter-pack... bsky.app/starter-pack...
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Ben Kellman @bkell1123.bsky.social · 17/11/2024
Structural bio bsky.app/starter-pack...
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Ben Kellman @bkell1123.bsky.social · 17/11/2024
bioinformatics and comp bio bsky.app/starter-pack... bsky.app/starter-pack... bsky.app/starter-pack...
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Ben Kellman @bkell1123.bsky.social · 17/11/2024
biotech bsky.app/starter-pack... bsky.app/starter-pack... bsky.app/starter-pack... ...
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Ben Kellman @bkell1123.bsky.social · 17/11/2024
glycotime bsky.app/starter-pack... bsky.app/starter-pack...), ...
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Ben Kellman @bkell1123.bsky.social · 17/11/2024
My starter packs (1) handy list of all (blueskydirectory.com/starter-packs), ...
blueskydirectory.com
Starter Packs - Bluesky Directory
A curated collection of all things relating to the Blue Sky social media platform.
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Reposted by Ben Kellman
Hiren Joshi @glyco.me · 12/11/2024
New bit of work from CCG, with our newest cellular framework - GlycoCarrier www.nature.com/articles/s41...
nature.com
Mammalian cell-based production of glycans, glycopeptides and glycomodules - Nature Communications
Access to defined human glycans is crucial for biomedical research. Here, authors report Glycocarriers, a mammalian cell-based method for the sustainable and scalable production of O-, N-glycans, and ...
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Reposted by Ben Kellman
Joost Snijder @joostsnijder.bsky.social · 12/11/2024
A B cell screen against endogenous retroviruses identifies glycan-reactive IgM that recognizes a broad array of enveloped viruses www.science.org/doi/full/10....
science.org
A B cell screen against endogenous retroviruses identifies glycan-reactive IgM that recognizes a broad array of enveloped viruses
Profiling of ERV-reactive B-1 cells in mice reveals natural antibodies against terminal N-acetylglucosamine on multiple viral envelope proteins.
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Reposted by Ben Kellman
Denis Wirtz @deniswirtz.bsky.social · 16/11/2024
Download our database of 313 different postdoctoral fellowships. For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship). Download our database here: research.jhu.edu/rdt/funding-...
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Ben Kellman @bkell1123.bsky.social · 17/11/2024
Partner and I got an icecream maker. Tldr, we think we can make some weird icecream with a bit of help from glycans! Will share if it's good or weird.
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Ben Kellman @bkell1123.bsky.social · 16/11/2024
Reposting for continuity... I believe we discovered a comprehensive mapping from protein structure to glycan structure, a genetic encoding for specific glycans, and a new paradigm in extracellular biology. www.biorxiv.org/content/10.1...
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Ben Kellman @bkell1123.bsky.social · 16/11/2024
go.bsky.app/CN9pS3u We are home!
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