A doença de Machado-Joseph, uma doença neurológica rara, hereditária e degenerativa, apresenta uma prevalência significativa em Portugal e não tem ainda cura nem uma terapia eficaz.

Nature - In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.

This study uncovers a new allosteric site in the Josephin domain of ataxin-3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells...

Bound! is a card game for students 12 and up, where players compete to match the most drugs to their protein targets.

Transcribed nucleotide repeat expansions can contribute to disease by altering RNA structure and function. Spinocerebellar ataxia type 37 (SCA37) is a neurodegenerative disorder caused by a pathogenic...

Letter to the Editor

Building on the success of the 2022 EMBO Workshop “When Predictions Meet Experiments: The Future of Structure Determination”, this second edition continues the journey at the interface of computation…

<p>Enquanto familiares e cuidadores desesperam, cientistas e médicos tentam deslindar os mistérios do Alzheimer. Em Portugal há 200 mil pacientes de demências, nem todos com lugar em lares especializa...