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Ben Mullish

@bhmullish.bsky.social
542 followers 251 following 25 posts

MRC Clinician Scientist Fellow and Honorary Consultant in Hepatology and Gastroenterology, based at Imperial College London. All comments in a personal capacity.

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Reposted by Ben Mullish
Ordo Fraterna Fibonacci @ordofibonacci.bsky.social · 16/12/2025
Combatting multidrug resistant bacteria in the clinic - Dr Ben Mullish - Part 1 of 2 Imperial College London youtu.be/5P3qBSOA2vU?...
youtu.be
Combatting multidrug resistant bacteria in the clinic - Dr Ben Mullish - Part 1 of 2
YouTube video by Imperial College London
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Ben Mullish @bhmullish.bsky.social · 02/06/2026
Pleased to see out this paper in #Gut on behalf of the @britsocgastro.bsky.social Gut Microbiota for Health panel - taking stock of where we have come in the last decade in translating gut #microbiome research: gut.bmj.com/content/earl... @imperialmdr.bsky.social
gut.bmj.com
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Reposted by Ben Mullish
The Lancet Gastroenterology & Hepatology @lancetgastrohep.bsky.social · 01/05/2026
🆕The use of pharmacotherapies in non-cirrhotic metabolic dysfunction-associated steatohepatitis: a UK expert consensus www.thelancet.com/journals/lan... #LiverSky #MedSky
thelancet.com
The use of pharmacotherapies in non-cirrhotic metabolic dysfunction-associated steatohepatitis: a UK expert consensus
Metabolic dysfunction-associated steatohepatitis (MASH), a potentially progressive form of metabolic dysfunction-associated steatotic liver disease (MASLD), increases risk of fibrosis progression, cir...
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Reposted by Ben Mullish
Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 19/03/2026
ICYMI: New online! Defining ‘gut health’: a leap forward, but still some road to travel
dlvr.it
Defining ‘gut health’: a leap forward, but still some road to travel
Nature Reviews Gastroenterology & Hepatology, Published online: 17 March 2026; doi:10.1038/s41575-026-01189-6‘Gut health’ is a widely used term, but there is much uncertainty and inconsistency related to its use. An international panel has now provided a definition that includes consideration of both gastrointestinal function and symptom burden. While advancing the field, the definition also prompts a number of areas of debate.
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Reposted by Ben Mullish
Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 18/03/2026
New online! Defining ‘gut health’: a leap forward, but still some road to travel
dlvr.it
Defining ‘gut health’: a leap forward, but still some road to travel
Nature Reviews Gastroenterology & Hepatology, Published online: 17 March 2026; doi:10.1038/s41575-026-01189-6‘Gut health’ is a widely used term, but there is much uncertainty and inconsistency related to its use. An international panel has now provided a definition that includes consideration of both gastrointestinal function and symptom burden. While advancing the field, the definition also prompts a number of areas of debate.
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Ben Mullish @bhmullish.bsky.social · 26/11/2025
Donor screening for #FMT gets ever more complicated, but is there rationale for this? Great to play a part in this critical appraisal and international Delphi process on this issue, now out in #Gut: gut.bmj.com/content/earl... @imperialmdr.bsky.social #GastroSky #IDSky #MicrobiomeSky
gut.bmj.com
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Reposted by Ben Mullish
Rob Brierley @robbrierley.bsky.social · 18/11/2025
New research @eClinicalMed - A large-scale comparison of clinical outcomes to IBD therapies in White and South Asian ethnicities www.thelancet.com/journals/ecl... #GastroSky #MedSky #IBDSky
thelancet.com
A large-scale comparison of clinical outcomes to IBD therapies in White and South Asian ethnicities
Treatment efficacy in similar WH and SA IBD patients recruited to the UK IBD BioResource is unaffected by ethnicity but patients from SA ethnic backgrounds are at increased risk of developing pancreat...
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Ben Mullish @bhmullish.bsky.social · 18/11/2025
Great to see out this study from Sharmili Balarajah and Laura Martinez-Gili @imperialmdr.bsky.social, working with the #IBD @nihrbioresource.bsky.social, comparing outcomes with #IBD therapies in White and South Asian patients, now in @eclinicalmed.bsky.social: www.sciencedirect.com/science/arti...
sciencedirect.com
A large-scale comparison of clinical outcomes to IBD therapies in White and South Asian ethnicities
While ethnic differences in IBD phenotype are recognised, the comparative efficacy and safety of common IBD therapies across ethnically diverse popula…
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Ben Mullish @bhmullish.bsky.social · 05/11/2025
Very pleased to see this practical guide to #nutrition in #cirrhosis out in #FrontlineGastroenterology: fg.bmj.com/content/earl.... Thanks to Luke Tyson for leading the group! #liversky
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Ben Mullish @bhmullish.bsky.social · 11/09/2025
Honoured to speak on #FMT #LBPs at the #EHMSG meeting today in session with Nicolas Benech and Jens Walter. Thanks to Gianluca Ianiro for organising, and for even getting a @nobelprize.bsky.social winner for Physics to speak to us, Giorgio Parisi! @imperialmdr.bsky.social #microbiomeclinicians
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Reposted by Ben Mullish
Mark Gilchrist @mgilchrist123.bsky.social · 10/08/2025
www.sciencedirect.com/science/arti... - we used an AMS approach to operationalise & formalise a structured approach to FMT @imperialcollegeldn.bsky.social @imperialnhs.bsky.social
sciencedirect.com
Operational considerations for the running of an NHS faecal microbiota transplant (FMT) service
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Ben Mullish @bhmullish.bsky.social · 10/08/2025
Out now from us in @thejhi.bsky.social - operational considerations in running an #NHS #FMT service: www.sciencedirect.com/science/arti... @imperialmdr.bsky.social @imperialbrc.bsky.social #GastroSky #MicroSky #IDSky
sciencedirect.com
Operational considerations for the running of an NHS faecal microbiota transplant (FMT) service
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Ben Mullish @bhmullish.bsky.social · 29/07/2025
Very pleased to see this out in @cmijournal.bsky.social - what non-antimicrobial options are there for recurrent #UTI, and what might be the role for #FMT? www.clinicalmicrobiologyandinfection.com/article/S119... @rohmaghani.bsky.social @imperialmdr.bsky.social @imperialbrc.bsky.social #MicroSky
clinicalmicrobiologyandinfection.com
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Reposted by Ben Mullish
Julie A. K. McDonald @julieakmcdonald.bsky.social · 22/07/2025
We’ve also written a Behind the Paper blog post to accompany our article, which you can find here: go.nature.com/401ctsa
go.nature.com
Antibiotics fuel the rise of vancomycin-resistant enterococci intestinal colonisation by remodelling the metabolic landscape of the gut microbiome
Antibiotics save lives- but also reshape the gut microbiome, unintentionally promoting VRE colonisation. This study reveals how antibiotic-driven metabolic shifts promote VRE expansion and highlights ...
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Ben Mullish @bhmullish.bsky.social · 18/07/2025
Great to see this work from Shiv Radhakrishnan and colleagues out in #GutMicrobes - using network analysis to explore #microbiome #metabolome interactions in an #IBD inception cohort: doi.org/10.1080/1949... @imperialmdr.bsky.social @imperialhepatology.bsky.social #IBDSky #GISky
doi.org
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Reposted by Ben Mullish
Julie A. K. McDonald @julieakmcdonald.bsky.social · 14/07/2025
So excited to share a new paper from my lab just published in Nature Communications! We showed that vancomycin-resistant enterococci (VRE) occupied distinct intestinal niches in the antibiotic-treated intestine. doi.org/10.1038/s414... Amazing work by first author Olivia King and colleagues!
doi.org
Vancomycin-resistant enterococci utilise antibiotic-enriched nutrients for intestinal colonisation - Nature Communications
Here, the authors show that vancomycin-resistant enterococci grow in the antibiotic-treated gut microbiome by utilising enriched nutrients in the presence of reduced concentrations of inhibitory micro...
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Reposted by Ben Mullish
ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · 11/07/2025
Vancomycin-resistant 𝙀𝙣𝙩𝙚𝙧𝙤𝙘𝙤𝙘𝙘𝙪𝙨 𝙛𝙖𝙚𝙘𝙞𝙪𝙢 (VRE) thrives in the antibiotic-perturbed gut VRE gobbles up enriched sugars and amino acids, and loss of short-chain fatty acids (acetate, propionate, butyrate) eliminates natural growth brakes Therapeutic angle: Prebiotic SCFA mixtures block VRE growth!
nature.com
Vancomycin-resistant enterococci utilise antibiotic-enriched nutrients for intestinal colonisation - Nature Communications
Here, the authors show that vancomycin-resistant enterococci grow in the antibiotic-treated gut microbiome by utilising enriched nutrients in the presence of reduced concentrations of inhibitory micro...
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Ben Mullish @bhmullish.bsky.social · 10/07/2025
A great privilege to work with @julieakmcdonald.bsky.social lab on this new paper, now out in @natureportfolio.nature.com Communications - how #antibiotic-related changes in gut #nutrients and #metabolites promote #VRE colonisation: doi.org/10.1038/s414... @imperialmdr.bsky.social
doi.org
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Ben Mullish @bhmullish.bsky.social · 10/05/2025
Honoured to to be part of this Future of Hepatology session at @easlnews.bsky.social #EASL2025, discussing the promise of #microbiome related therapies in #PSC #cholestatic liver disease - where have we come since the original #FMT #PSC pilot study by @DrAllegrettiIBD? doi.org/10.14309/ajg...
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MAST Study @mast-study.bsky.social · 28/03/2025
Delighted to welcome Manchester Royal Infirmary onto the #MAST trial as our seventh site! Pleased to be able to expand our coverage for this important trial of #GutMicrobiome manipulation with #IMT #FMT before #HCT; find out more here: www.imperial.ac.uk/metabolism-d... @imperialmdr.bsky.social
imperial.ac.uk
MAST study
The Imperial MAST study: Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) study.
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Reposted by Ben Mullish
MAST Study @mast-study.bsky.social · 19/03/2025
Want to know more about why we are looking at the #GutMicrobiome #IMT #HCT as therapy? Find out even more here: youtu.be/zDd1qdVCa6A?...
youtu.be
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Reposted by Ben Mullish
MAST Study @mast-study.bsky.social · 19/03/2025
The #MAST trial is pushing forward, investigating the impact of #IMT #FMT prior to #HCT in seven UK centres #HaemSky #MicrobiomeSky #GastroSky @imperialmdr.bsky.social @bloodcanceruk.bsky.social ruk.bsky.social @anthonynolan.bsky.social. Find out more from our poster or our website: rb.gy/myizsb
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Reposted by Ben Mullish
medRxivpreprint @medrxivpreprint.bsky.social · 13/03/2025
The relationships between MASLD, extrahepatic multimorbidity and all-cause mortality in UK Biobank cohort www.medrxiv.org/content/10.1101/202…
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Ben Mullish @bhmullish.bsky.social · 06/03/2025
A great first day at the #BSG #GutMicrobiome event, covering everything from early life @halllab.bsky.social, to #liver @debbieshawcross.bsky.social, to #cancer @jameskinross.bsky.social, and culminating in a tour de force on #IBD and the #microbiome in clinical practice from Prof Harry Sokol
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MAST Study @mast-study.bsky.social · 22/01/2025
MAST is moving onwards and upwards and now up to 18 recruited patients. We push on, hoping to see how gut #microbiome manipulation with #IMT #FMT can help our patients with #BloodCancer #HCT @bloodcanceruk.bsky.social @anthonynolan.bsky.social
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Ben Mullish @bhmullish.bsky.social · 07/01/2025
Pleased that #FARGO - a randomised, multicentre, placebo-controlled phase IIa trial of #FMT to treat #PSC - is running and recruiting. Have a look at the protocol paper out now in #BMJOpen: doi.org/10.1136/bmjo... @pscsupport.bsky.social @cholestasisdoc.bsky.social
doi.org
FAecal micRobiota transplantation in primary sclerosinG chOlangitis (FARGO): study protocol for a randomised, multicentre, phase IIa, placebo-controlled trial
Introduction Primary sclerosing cholangitis (PSC) is the classical hepatobiliary manifestation of inflammatory bowel disease (IBD). The strong association between gut and liver inflammation has driven...
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Ben Mullish @bhmullish.bsky.social · 22/12/2024
Great that the #MAST trial is moving ahead, and really hoping that this shows the #microbiome as a route to give new treatment prospects to #HCT #BloodCancer patients @bloodcanceruk.bsky.social @cancerresearchuk.org
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Ben Mullish @bhmullish.bsky.social · 14/12/2024
Great work by Nabil Quraishi, Palak Trivedi and many others - unravelling the positive impact of #vancomycin in #PSC #IBD by altering interactions between the host, #microbiome, and #metabolome. Now in #JCC: academic.oup.com/ecco-jcc/adv... #GastroSky
academic.oup.com
Open label vancomycin in primary sclerosing cholangitis-inflammatory bowel disease: improved colonic disease activity and associations with changes in host-microbiome-metabolomic signatures
AbstractBackground. We conducted a single-arm interventional study, to explore mucosal changes associated with clinical remission under oral vancomycin (OV
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Ben Mullish @bhmullish.bsky.social · 13/12/2024
Great to work with the lab of @julieakmcdonald.bsky.social and see this preprint out on @biorxivpreprint.bsky.social, looking at how nutrient availability and microbial #metabolites impact #VRE colonisation in the #antibiotic treated gut: www.biorxiv.org/content/10.1... #MicroSky #GastroSky
biorxiv.org
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Ben Mullish @bhmullish.bsky.social · 07/12/2024
Great work by Sharmili Balarajah with #ImperialMDR colleagues and the @nihr.bsky.social #IBD Bioresource team, now in press in #JCC - exploring differences in #IBD phenotypes and treatment approaches between White and South Asian patients in the UK: academic.oup.com/ecco-jcc/adv...
academic.oup.com
Diverse phenotypes, consistent treatment: a study of 30,997 South Asian and White IBD patients using the UK IBD BioResource
AbstractObjective. To evaluate South Asian (SA) and White (WH) inflammatory bowel disease (IBD) phenotypes, and to explore treatment approach variations be
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Ben Mullish @bhmullish.bsky.social · 06/12/2024
Thanks to Gianluca Ianiro for co-ordinating the international consensus statement on #microbiome testing in clinical practice, now in Lancet GastroHep - an assessment of where we are and where we hope to go: doi.org/10.1016/S246... #GastroSky #MedSky
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Ben Mullish @bhmullish.bsky.social · 03/12/2024
Unstoppable in the name of #AMR, even if it means being poisoned by The Thames - #microbiome manipulator extraordinaire, Prof Julian Marchesi @gut-health.bsky.social
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Reposted by Ben Mullish
MAST Study @mast-study.bsky.social · 02/12/2024
We are pleased that the #MAST study is live on @bsky.app! Read here 👇 about this trial of modulating the #GutMicrobiome using #IMT #FMT prior to #HCT for #BloodCancer 🩸🦠: www.imperial.ac.uk/metabolism-d... #MRC #EnteroBiotix @anthonynolan.bsky.social @bloodcanceruk.bsky.social
imperial.ac.uk
MAST study
The Imperial MAST study: Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) study.
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Ben Mullish @bhmullish.bsky.social · 20/11/2024
An extraordinary read of incredible braveness in a horrific situation in this week’s #NEJM: www.nejm.org/doi/full/10....
nejm.org
Fight or Flight — Facing the Marburg Outbreak in Rwanda | NEJM
Having diagnosed two ICU patients with the first known cases of Marburg virus disease in Rwanda, a physician must prioritize limiting spread, despite pleas for transfer from the patients’ families.
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Ben Mullish @bhmullish.bsky.social · 13/11/2024
Great to have our new review out - what we do and don't know about how clinical, biological and procedural considerations impact the efficacy of #IMT #FMT in repairing the #GutMicrobiome: www.tandfonline.com/doi/full/10.... … a great team effort
tandfonline.com
Faecal (or intestinal) microbiota transplant: a tool for repairing the gut microbiome
Faecal/intestinal microbiota transplant (FMT/IMT) is an efficacious treatment option for recurrent Clostridioides difficile infection, which has prompted substantial interest in FMT’s potential rol...
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