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@BaSyCresearch

@basycresearch.bsky.social
57 followers 32 following 27 posts

Building a Synthetic Cell (BaSyC) is a research programme with the goal of building an autonomous, self-reproducing synthetic cell. www.basyc.nl

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@BaSyCresearch @basycresearch.bsky.social · 17/09/2026
Another BaSyC PhD thesis defense coming up! 🙂 Marijn van den Brink will defend her PhD thesis 🎓on 22 September 2026 at 12:30 in Delft. Title of her dissertation: ‘Laboratory evolution of synthetic cells’. Good luck Marijn!
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EMBO @embo.org · 26/01/2026
Learn more about the basic physical principles that underlie the behaviour of living cells in the EMBO Workshop "#Physics of Cells: PhysCell2026" in Egmond aan Zee, Netherlands, 7–11 September 2026. Deadline: 8 May meetings.embo.org/event/26-physcell #EMBOphysCell26 #meeting #EMBOevents 🧪
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@BaSyCresearch @basycresearch.bsky.social · 23/06/2026
Nice article Asif, Arnab, Pim and David!
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David Dulin @dulinlab.bsky.social · 20/06/2026
Copy-back RNA synthesis by coronavirus polymerase requires helicase activity and is stimulated by remdesivir and molnupiravir | Science Advances www.science.org/doi/10.1126/... #Coronavirus #SARS2 #COVID19 #singlemolecule #biophysics #magnetictweezers
science.org
Copy-back RNA synthesis by coronavirus polymerase requires helicase activity and is stimulated by remdesivir and molnupiravir
Helicase-driven copy-back RNA synthesis in coronaviruses reveals how antivirals trap replication intermediates.
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Matthias Heinemann @matthiasheinemann.bsky.social · 10/04/2026
🧵 Our new paper is out today in molecularcell.bsky.social! After 7 years of a truly intriguing discovery journey, we can finally share what controls how molecules move inside living E. coli cells. Spoiler: it's not what the field thought. A thread 👇 📄 doi.org/10.1016/j.molcel.2026.03.018
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Siewert-Jan Marrink @cg-martini.bsky.social · 27/05/2026
pubs.acs.org
Martini 3 Metabolome
Metabolites are ubiquitous in all living cells and are essential mediators of biochemical processes, serving either as substrates or as cofactors to enable reactions. Capturing this diversity in compu...
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Cees Dekker @ceesdekker.bsky.social · 04/05/2026
Van scepsis naar doorbraak: synthetische cel komt binnen handbereik: tw.nl/van-scepsis-...
tw.nl
Van scepsis naar doorbraak: synthetische cel komt binnen handbereik - TW.nl
Wat begon als een ‘moonshot’-project is tien jaar later toch hard op weg om praktisch toepasbare resultaten op te leveren: de bouw van een synthetische cel. Het doel is om de werking van een…
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Cees Dekker @ceesdekker.bsky.social · 19/05/2026
Just in - glazed and baked: My own personal Delft Blue tile! This is a great souvenir from the SynCell Global Summit Delft 2026, where every participant painted their own vision of a synthetic cell (which in my case is just about to divide, driven by entropically segregating DNA and CDV proteins).
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Protein Society @proteinsociety.bsky.social · 13/03/2026
How do we build realistic cellular environments for simulations? @cg-martini.bsky.social, @ma3ke.bsky.social, @janstevens.bsky.social answer this with Bentopy, an integration tool for proteomics, metabolomics, and structural data that rapidly assembles simulation-ready molecular models.
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Cees Dekker @ceesdekker.bsky.social · 24/02/2026
Very special: Thrilled to be honored by the ‘2026 Kazuhiko Kinosita Award in Single-Molecule Biophysics’ from the Biophysical Society today, ‘for groundbreaking contributions to the field of nanobiology and single-molecule biophysics, from nanopores to SMC molecular motors’. Wow! Wow…
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Cees Dekker @ceesdekker.bsky.social · 09/03/2026
Ver­plet­te­rend ont­zag­wek­kend! Wetenschap leidt tot verwondering en aanbidding: www.eo.nl/artikel/van-...
eo.nl
Van nanometer tot sterrenstelsel: 'Ontzagwekkend!'
Of je nu inzoomt op DNA of uitkijkt over miljarden sterrenstelsels: zowel het kleinste als het grootste ademt pure majesteit.
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@BaSyCresearch @basycresearch.bsky.social · 15/04/2026
Single Molecule Protein Sequencing 2026 conference in Thailand: smps2026.nstda.or.th
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Cees Dekker @ceesdekker.bsky.social · 01/04/2026
Latest #CDlab paper on BioRxiv: www.biorxiv.org/content/10.6... PhD student Bert van Herck developed a route towards efficiently delivering lipids and proteins to synthetic cells through DNA-driven fusion of SUVs to GUVs. Great collaboration with labs of Gijsje Koendrink & Stefan Vogel.
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@BaSyCresearch @basycresearch.bsky.social · 15/04/2026
Recent BaSyC Scientific papers (2026)📄💻🎊: edu.nl/7tefn 23 Feb, Nature Reviews Bioengineering edu.nl/jxhwf 20 Feb, Journal of the American Chemical Society edu.nl/me3f7 13 Feb, Nature Communications edu.nl/xc9hj January, JBC Journal of Biological Chemistry
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@BaSyCresearch @basycresearch.bsky.social · 21/01/2026
Bacterially grown living materials with resistant and on-demand functionality | Science Advances www.science.org/doi/10.1126/...
science.org
Bacterially grown living materials with resistant and on-demand functionality
Resilient bacterial cellulose–based living materials store dormant spores, awakening to deliver programmable functions.
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Sonja Schmid @scisonja.bsky.social · 02/11/2025
Single-molecule friends! The prelim. program of next year's sm- #Gordon conference in Switzerland is online: www.grc.org/single-molec... It'll be 3x fantastic: science, people, place in the alps ⛰️. Kevin & I hope to see you all next June: Have a look, tell your friends, and register!
grc.org
2026 Single Molecule Approaches to Biology Conference GRC
The 2026 Gordon Research Conference on Single Molecule Approaches to Biology will be held in Les Diablerets, Vaud (fr) Switzerland. Apply today to reserve your spot.
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Cees Dekker @ceesdekker.bsky.social · 06/11/2025
This large 10 M€ grant will allow us to explore novel aspects such as the SMC molecular motor mechanism, the many ‘control knobs’ on these motors, and their role in gene expression, e.g. in facilitating enhance-promotor interactions and silencing extrachromomosal circular DNA.
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@BaSyCresearch @basycresearch.bsky.social · 21/01/2026
Interesting paper from our BaSyC member @romanbarth.bsky.social!
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@BaSyCresearch @basycresearch.bsky.social · 21/01/2026
BaSyC PhD thesis defense coming up, 1st one in 2026! 🙂 Luca Gross will defend his PhD thesis 🎓on 9 February 2026 at 17:30 in Delft. Title of his dissertation: ‘Chaperone-mediated protein folding and rescue: A single-molecule optical tweezers study’. Good luck Luca! www.tudelft.nl/en/evenement...
tudelft.nl
Doctoral defence L.D. Gross
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@BaSyCresearch @basycresearch.bsky.social · 26/11/2025
Congrats @ykjawale.bsky.social 🎓🎉 Nice pictures 📸
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@BaSyCresearch @basycresearch.bsky.social · 03/11/2025
www.sciencelink.net/verdieping/e... Another interesting interview with Liedewij Laan (in Dutch).
sciencelink.net
‘Er zijn meerdere routes om als bèta impact te hebben’
Het is onder bèta's bon ton om te klagen over het gebrek aan bèta's bij de overheid. Tegelijkertijd wordt een loopbaan in beleid of bestuur door diezelfde groep nauwelijks voor vol aangezien. Die houding is natuurkundige Liedewij Laan een doorn in het oog.
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@BaSyCresearch @basycresearch.bsky.social · 03/11/2025
Nice interview with Liedewij Laan, Nico Claassens and Kristin Grußmayer (in Dutch): bionieuws.nl/article/1875...
bionieuws.nl
Levensechte labcellen
DOOR RUBEN BOOT - ILLUSTRATIE: CEES DEKKER LAB / SCIXEL - 20-06-2025 - Celbiologie
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Cees Dekker @ceesdekker.bsky.social · 26/06/2025
Gisteren kunstproject 'Am I alive?' gezien van de enthousiaste 'Emergence' studenten van TUDelft & kunstacademies. Geïnspireerd door ons onderzoek hebben zij afgelopen half een installatie rond 'synthetische cellen' gebouwd www.emergencedelft.nl/nmp4-synthet... www.dehavenloods.nl/agenda/2025/...
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Cees Dekker @ceesdekker.bsky.social · 13/08/2025
Building a synthetic cell together - nice common perspective written by many leading scientists who gathered in Shenzhen China for the inaugural ‘SynCell Global Summit’. Check it out in Nature Comm: www.nature.com/articles/s41...
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Cees Dekker @ceesdekker.bsky.social · 22/08/2025
WORK: 5 (!) openings in our #CDlab, check it out: ceesdekkerlab.nl/come-join-us/
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Cees Dekker @ceesdekker.bsky.social · 19/09/2025
As in so many ways I very much still feel like a novice student in exploring biology, I am very grateful and proud for this Award of the Biochemical Society 'for significant achievements in nanoscale molecular biology, especially the contribution to developing methodologies'.
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@BaSyCresearch @basycresearch.bsky.social · 29/09/2025
Congrats @ceesdekker.bsky.social! 🎉
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@BaSyCresearch @basycresearch.bsky.social · 20/08/2025
Nice article from @mkeulemans.bsky.social who interviews BaSyC PI John van der Oost (in Dutch) www.volkskrant.nl/wetenschap/a...
volkskrant.nl
Als grondlegger van het revolutionaire knippen in DNA greep hij net naast de Nobelprijs. Maar wie weet wat er nog komt…
Scheidend hoogleraar John van der Oost stond aan de basis van de grootste biologische doorbraak van afgelopen decennia – de Nobelprijs ontglipte hem maar net. De echte DNA-revolutie moet nog komen, ze...
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@BaSyCresearch @basycresearch.bsky.social · 20/08/2025
Another BaSyC PhD thesis defense coming up! 🙂 Céline Cleij will defend her PhD thesis 🎓on 18 September 2025 at 12:30 in Delft. Title of her dissertation: ‘Building the genome of a minimal synthetic cell’. Good luck Céline!
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@BaSyCresearch @basycresearch.bsky.social · 20/08/2025
BaSyC PhD thesis defense coming up! 🙂 Yash Jawale will defend his PhD thesis 🎓on 12 September 2025 at 12:30 in Delft. Title of his dissertation: ‘Building Minimal Spindles: Reconstituting spindle positioning in synthetic cells’. Good luck @ykjawale.bsky.social!
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@BaSyCresearch @basycresearch.bsky.social · 16/07/2025
Congrats Timon!
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@BaSyCresearch @basycresearch.bsky.social · 16/07/2025
Nice picture taken during the BaSyC/EVOLF spring meeting last month! In the picture the EVOLF community, growing rapidly 👭👫👬
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Cees Dekker @ceesdekker.bsky.social · 17/06/2025
Just spoke with PhD student Olga Rook. She did a survey on public attitudes to synthetic cells, see journals.plos.org/plosone/arti... Overall she finds great support, with only ~10% of people objecting to synthetic cell research and applications.
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@BaSyCresearch @basycresearch.bsky.social · 16/07/2025
BPS2026 Annual meeting is in San Francisco next year from 21-25 February.
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Cell Reports @cp-cellreports.bsky.social · 02/07/2025
Telomeres stall DNA loop extrusion by condensin
dlvr.it
Telomeres stall DNA loop extrusion by condensin
Analikwu et al. show that dense linear arrays of the telomeric protein Rap1 on DNA block DNA loop extrusion by condensin. Rap1-induced stalling depends on array length and protein density and leads to a local chromatin decompaction during anaphase, revealing how protein arrays can regulate SMC-driven genome organization.
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@BaSyCresearch @basycresearch.bsky.social · 04/06/2025
www.fredhutch.org/content/www/... including @romanbarth.bsky.social
fredhutch.org
Fred Hutch announces 10 recipients of the 2025 Harold M. Weintraub Graduate Student Award
Fred Hutch announces 10 recipients of the prestigious 2025 Harold M. Weintraub Graduate Student Award
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European Synthetic Cell Initiative @syncelleu.bsky.social · 10/04/2025
SynCell conferences - Save the dates! SynCell2025: 9-11 September 2025 at Stanford, USA. Further info: www.buildacell.org/syncell2025 SynCell2026: 22-24 April 2026, Institute of Physics in London, UK. Registration opens in Autumn 2025. More info will follow in due course at syntheticcell.eu
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European Synthetic Cell Initiative @syncelleu.bsky.social · 01/05/2025
Let's get an update on @comeincell.bsky.social, the MSCA doctoral network that aims to develop advanced cellular mimics to shed light on complex cellular mechanisms and accelerate innovation. We interviewed Rumiana @dimovalab.bsky.social, the consortium's coordinator syntheticcell.eu/update-on-co...
syntheticcell.eu
Update on ComeInCell, MSCA Doctoral Network
Interview with Rumiana Dimova on ComeInCell, a doctoral network to shed light on complex cellular mechanisms and accelerate innovation
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Cees Dekker @ceesdekker.bsky.social · 08/04/2025
Wow, I feel greatly honored by being awarded the 2026 Biochemical Society Award for Significant Breakthrough or Achievement, as was just announced! www.biochemistry.org/about-us/new... It is wonderful that the Biochemical Society honors our contributions to single-molecule biophysics in this way!
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Cees Dekker @ceesdekker.bsky.social · 14/04/2025
Now out in print, our review 'Single-molecule protein sequencing with nanopores' in Nature Reviews Bioengineering: www.nature.com/articles/s44...
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@BaSyCresearch @basycresearch.bsky.social · 08/05/2025
Congrats @ceesdekker.bsky.social!
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@BaSyCresearch @basycresearch.bsky.social · 08/05/2025
Nice coverstory in Pioneering Tech (ENG+NL) about the synthetic cell: 'Factory of the future' with BaSyC PI Marileen Dogterom @marileend.bsky.social (and check out the brand new image of synthetic cells from BaSyC PhD Federico Ramirez Gomez (Koenderink & Danelon labs).
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labnikel.bsky.social @labnikel.bsky.social · 04/04/2025
Interested in engineering bacteria to turn #C1feedstocks into high-value chemicals for #bioproduction? Here is a thread summarizing our latest review on the roadblocks and how we might bio-hack our way past them 🧵 1/n academic.oup.com/femsre/advan...
academic.oup.com
Seven Critical Challenges in Synthetic One-Carbon Assimilation and Their Potential Solutions
Abstract. Synthetic C1 assimilation holds the promise of facilitating carbon capture while mitigating greenhouse gas emissions, yet practical implementatio
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KNAW - Koninklijke Nederlandse Akademie van Wetenschappen @knaw-nl.bsky.social · 11/02/2025
Onderzoeker en viroloog John van der Oost wint de #Beijerinck #Virologie Prijs voor zijn CRISPR-Cas onderzoek. Early career onderzoekers Carmen Embregts & Puck van Kasteren ontvangen de #BeijerinckPremie. www.knaw.nl/nieuws/voorb... @rdo-erasmusmc.bsky.social @rivm-nl.bsky.social @w-u-r.bsky.social
John van der Oost, fotocredit Rafaël PhilippenCarmen EmbregtsPuck van Kasteren
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Cees Dekker @ceesdekker.bsky.social · 03/03/2025
Latest #CDlab paper online in @labonachip.rsc.org: pubs.rsc.org/en/content/a... Here, 1st authors Alex Joesaar & Martin Holub developed a microfluidics platform to extract and study full length megabase-size genomes in microfluidic chambers (where they are protected against shearing by flow)!
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Nico Claassens @nicoc-micsynmet.bsky.social · 14/03/2025
Very happy to contribute to this work (a bit) and see Simona, Enrico and Costas finally cracking the CRISPR-Cas genome engineering challenge in my favorite bug C. necator!
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@BaSyCresearch @basycresearch.bsky.social · 19/03/2025
Checkout this article I found at PLOS: dx.plos.org/10.1371/jour... from our BaSyC colleagues Olga, Marileen and Hub!
dx.plos.org
Public attitudes to potential synthetic cells applications: Pragmatic support and ethical acceptance
Synthetic cells constructed bottom-up represent a novel direction in Synthetic Biology. It has the potential to deepen the scientific understanding of life and, in the longer run, to open up new pathw...
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@BaSyCresearch @basycresearch.bsky.social · 19/03/2025
BaSyC PI John van der Oost ontvangt de M.W. Beijerinck Virologie Prijs van de KNAW! Voorbij de grenzen van de virologie: M.W. Beijerinck Virologie Prijs voor revolutionaire DNA-techniek knaw.nl/nieuws/voorb...
knaw.nl
Voorbij de grenzen van de virologie: M.W. Beijerinck Virologie Prijs voor revolutionaire DNA-techniek - Beijerinck Premie voor onderzoekers Carmen Embregts en Puck van Kasteren - KNAW
Een revolutionaire techniek om genen in het DNA aan te passen, onderzoek naar de afweerreactie tegen het rabiësvirus en onderzoek naar vaccins tegen luchtwegeninfecties: drie virologen ontvangen erken...
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@BaSyCresearch @basycresearch.bsky.social · 19/03/2025
Congrats @romanbarth.bsky.social 🥳
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European Synthetic Cell Initiative @syncelleu.bsky.social · 17/03/2025
Several positions available in Cees Dekker's lab!
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