iiinova — where your digital self keeps evolving

Reposted by Ava Khamseh

Journal of Open Source Software @joss-openjournals.bsky.social · 24/03/2026

Just published in JOSS: 'TarGene: A Nextflow pipeline for the estimation of genetic effects on human traits via semi-parametric methods.' doi.org/10.21105/joss.09603

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Reposted by Ava Khamseh

Chris Ponting @cgatist.bsky.social · 16/11/2025

New📢 Between molecular and human traits is a yawning gap: What do molecules do to single cells? We tested *all* human or mouse miRNA mimics for their cell morphological effects on 5 cell lines. To do so, we applied Cell Painting at the *single cell* level (100,000+ images). doi.org/10.1101/2025...

doi.org

Systematic morphological profiling of human and mouse miRNAs in 24M single cells

MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression whose contributions to cell biology remain underexplored. Here, we used Cell Painting to quantify the morphological effect of ...

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Ava Khamseh @avakhamseh.bsky.social · 01/10/2025

We integrate population genetics, functional genomics & targeted ML to uncover 100s of TF-linked epistatic interactions across 768 traits in UK Biobank. Epistasis, informed by mechanism, empowered by robust stat/ML, is detectable & widespread. doi.org/10.1101/2025... (1/n)

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Ava Khamseh @avakhamseh.bsky.social · 12/08/2025

New course “EMBO Causality in Biomedicine”: We have organised the first EMBO course in *causal* stats/ML methods for quantitative biomedicine. @sjoerdvbeentjes.bsky.social @nimahejazi.org @pablormier.bsky.social @DariaSokolova @CarolineUhler Very much looking forward to teaching and discussing!

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Reposted by Ava Khamseh

Chris Ponting @cgatist.bsky.social · 03/01/2025

📢Now published! Know that clustering cells in reduced dimensions is problematic? Want to identify cell subtypes or states *without* clustering? Then check out Stator which finely resolves states & subtypes even among apparently homogeneous cells Thread www.embopress.org/doi/full/10....

embopress.org

High order expression dependencies finely resolve cryptic states and subtypes in single cell data | Molecular Systems Biology

imageimageStator assigns multiple states and (sub)types to a single cell using coordinated gene expression and/or non-expression in a data-driven manner. Its application of structure learning has incr...

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Reposted by Ava Khamseh

Mike Morgan @mdmorgan.bsky.social · 13/12/2024

I am STOKED that myself and @avakhamseh.bsky.social are looking for a joint EastBIO PhD candidate across @uniofaberdeen.bsky.social and @uoe-sps.bsky.social to develop cutting-edge statistical models at the interface of single cell genomics and quantitative genetics: shorturl.at/vQo0P pls reskeet!

shorturl.at

EASTBIO: Mapping DNA variants to cell states in health and disease at University of Aberdeen on FindAPhD.com

PhD Project - EASTBIO: Mapping DNA variants to cell states in health and disease at University of Aberdeen , listed on FindAPhD.com

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