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Xiufeng Li

@assumeassume.bsky.social
22 followers 34 following 3 posts

PhD @tsinghuauniversity.bsky.social | Postdoc @vibai.bsky.social | Epigenomics, Retrotransposon, 3D genomics, Transcriptional Regulation & enhancer modelling Homepage: assumeassume.github.io

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Reposted by Xiufeng Li
Cas Blaauw @casblaauw.eurosky.social · 22/09/2026
Excited to show deepSCENIC to the world! GRNs meet sequence-to-function models: explicit TF-region and region-gene links, with the power of enhancer DL models, predicting RNA & ATAC at single-cell resolution. Check out the examples in the paper or try it on your own data: github.com/aertslab/Dee...
github.com
GitHub - aertslab/deepSCENIC: Deep learning for single-cell Gene Regulatory Networks
Deep learning for single-cell Gene Regulatory Networks - aertslab/deepSCENIC
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Reposted by Xiufeng Li
VIB.AI @vibai.bsky.social · 14/09/2026
New group leader recruitment call now open. 📣 Together with KU Leuven, we are looking for two Principal Investigators to join VIB.AI and build ambitious independent research programs on AI in biology. Apply by 15 November 2026 vib.ai/en/join-vibai-group-leader-a…
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Xiufeng Li @assumeassume.bsky.social · 04/09/2026
Finally here joining Stein Aerts’ lab @steinaerts.bsky.social at VIB.AI @vibai.bsky.social for my postdoctoral research! Feels so special to arrive at this new chapter. Hope I can keep the passion, stay curiours and make more exciting discoveries!
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Reposted by Xiufeng Li
Shenzhi Chen @shenzhichen1999.bsky.social · 25/08/2026
Excited to share our paper in @natgenet.nature.com on the de novo design of tissue-specific mammalian enhancers that function in vivo in mouse embryos. 🧬🐭 www.nature.com/articles/s41...
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Reposted by Xiufeng Li
Epigenome Technologies @epigenometech.bsky.social · 30/07/2026
Epigenetics Update - Condensates of the chromatin regulator ANKRD11 restrict hypertranscribed genes to safeguard development u.epigenome.us/XHlUqkVP Tao Zhang / assumeassume.bsky.social & Nian Liu in Cell #Epigenetics #Condensates #Chromatin #ANKRD11 --- Gain deeper insights at epigenometech.com
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Reposted by Xiufeng Li
Cell - a Cell Press journal @cp-cell.bsky.social · 22/07/2026
Now online! Condensates of the chromatin regulator ANKRD11 restrict hypertranscribed genes to safeguard development
dlvr.it
Condensates of the chromatin regulator ANKRD11 restrict hypertranscribed genes to safeguard development
ANKRD11 restricts hypertranscribed genes by forming biomolecular condensates that spatially sequester elongation factors, with disruption of this condensate-mediated control leading to aberrant organogenesis and underlying the pathogenesis of developmental disorders like KBG syndrome.
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Xiufeng Li @assumeassume.bsky.social · 22/07/2026
Excited to share our paper in Cell @cp-cell.bsky.social showing that ANKRD11 condensates restrain hypertranscribed loci to safeguard development. Huge thanks to my collaborator Tao Zhang, and to my PhD mentor Nian Liu! www.cell.com/cell/fulltex...
cell.com
Condensates of the chromatin regulator ANKRD11 restrict hypertranscribed genes to safeguard development
ANKRD11 restricts hypertranscribed genes by forming biomolecular condensates that spatially sequester elongation factors, with disruption of this condensate-mediated control leading to aberrant organo...
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Reposted by Xiufeng Li
VIB.AI @vibai.bsky.social · 30/06/2026
The @steinaerts.bsky.social lab received an ERC Proof of Concept Grant to develop CellTuned: an AI platform that combines sequence-to-function models with single-cell regulatory networks to uncover the mechanisms driving disease, and translate them into new therapeutic opportunities. 👏 celltuned.ai
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Reposted by Xiufeng Li
Olga Sigalova @olgasigalova.bsky.social · 16/04/2026
Happy to share our new preprint on non-coding genetic variation in the human brain and Parkinson's disease. Great team effort with @alexanrna.bsky.social, @juliedeman.bsky.social, Koen Theunis, and all co-authors, supervised by @steinaerts.bsky.social and @jdemeul.bsky.social. Thread below:
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Reposted by Xiufeng Li
Trends in Genetics @cp-trendsgenetics.bsky.social · 16/05/2025
Online Now! A new Review: "Advances in understanding LINE-1 regulation and function in the human genome" by Xiufeng Li (李秀峰) & Nian Liu (刘念) Read for FREE till July 5th using this link: authors.elsevier.com/a/1l6BQcQbJF...
Figure 1. LINE-1 (L1) elements dispersed across the genome include various families, subfamilies, lengths, and sequences.
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Reposted by Xiufeng Li
VIB.AI @vibai.bsky.social · 03/04/2026
The @steinaerts.bsky.social lab published CREsted, an end-to-end modeling framework to 🧬 Train sequence-based enhancer models on large sc datasets 🔍 Decode enhancer logic with nucleotide-level interpretability ⚙️ Design synthetic enhancers with cell-type specificity tinyurl.com/ypurmrw5
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