iiinova — where your digital self keeps evolving

Adrienne Asher @asheradrienne.bsky.social · 20/07/2025

89% of patients with Mast Cell Activation Syndrome (MCAS) had significant reduction in symptoms from GLP-1RAs. It is thought that these drugs stabilize mast cells and reduce inflammation. The authors recommend future randomized trials of these drugs in patients with #LongCOVID.

sciencedirect.com

Utility of Glucagon-Like-Peptide-1-Receptor Agonists in Mast Cell Activation Syndrome

Introduction: Mast cell (MC) activation syndrome (MCAS) is a collection of illnesses rooted in inappropriate MC activation with little to no neoplasti…

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Adrienne Asher @asheradrienne.bsky.social · 19/07/2025

Facinating article about Dr. Michael Peluso, MD, an infectious disease clinician and researcher, as well as the director and one of the co-creators of the large Long Term Impact of Infection with Novel Coronavirus (LIINC) project at UCSF. #LongCovid

healthrising.org

"Excited Every Day": Dr. Michael Peluso on LIINC, Long COVID and ME/CFS - Health Rising

Dr. Michael Peluso talks about the LIINC long COVID project, why he's excited every day about long COVID, and what he hopes the next 5 years will bring.

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Reposted by Adrienne Asher

Eric Topol @erictopol.bsky.social · 16/05/2025

On finding treatments for #LongCovid “What’s so sad here is people are so desperate, and we don’t have anything [of so many solid candidates] validated." gift link: www.washingtonpost.com/wellness/202...

washingtonpost.com

Long covid patients are desperate for treatments. These trials may help.

Some trials are focusing on drugs that target the immune system, which is affected by different pathways to long covid.

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Adrienne Asher @asheradrienne.bsky.social · 18/05/2025

Saw my new cardiologist a few days ago for #LongCovid issues (PEM, POTS). Two techs walk in, unmasked. I politely ask them to wear masks. “What?! Me?!” Yes, please. You. Why must this always be an issue? So tired of negotiating every. single. thing.

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Adrienne Asher @asheradrienne.bsky.social · 13/05/2025

Perhaps most fascinating is how mindfulness recalibrates our relationship with difficult experiences; pain, anxiety, and other challenging sensations become objects of curious attention rather than threats to be avoided, creating a fundamental shift in how we embody distress. (3/end)

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Adrienne Asher @asheradrienne.bsky.social · 13/05/2025

This neurological remodeling translates to measurable health outcomes: reduced inflammatory markers, improved immune function, enhanced vagal tone, and greater heart rate variability—all physiological signatures of resilience. (2)

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Adrienne Asher @asheradrienne.bsky.social · 13/05/2025

Published research from Harvard’s Mass. General Hospital reveals that 8 weeks of regular mindfulness practice physically thickens brain regions involved in bodily awareness, while simultaneously reducing activity in the brain circuit responsible for mind-wandering and self-referential thinking. (1)

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Adrienne Asher @asheradrienne.bsky.social · 13/05/2025

Using single-cell analysis, scientists in China uncovered widespread changes in alternative polyadenylation of mRNA in brain-related cells after COVID. These disruptions may contribute to neurological and psychiatric symptoms observed in #LongCOVID patients. www.biorxiv.org/content/10.1...

biorxiv.org

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Adrienne Asher @asheradrienne.bsky.social · 13/05/2025

A preprint from Germany reports that 68 individuals with #LongCOVID had unusually active CD8+ T cells and elevated IL-3 levels. These immune signatures could help identify patients at risk and guide development of targeted therapies. www.sciencedirect.com/science/arti...

sciencedirect.com

Hyper-reactivity of CD8+ T cells and high expression of IL-3 correlates with occurrence and severity of Long-COVID

Following SARS-CoV-2 infection, some individuals develop Long-COVID-syndrome lasting for more than 3 months. We analyzed blood samples from patients w…

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Adrienne Asher @asheradrienne.bsky.social · 13/05/2025

Advanced imaging like PET/MRI and DECT revealed myocarditis, vascular inflammation, pulmonary infiltrates, and perfusion defects in a majority of patients. Blood tests also showed abnormal protein profiles linked to inflammation. (2)

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Adrienne Asher @asheradrienne.bsky.social · 13/05/2025

A preprint study from Mount Sinai found that 57% of Respiratory Long COVID patients with ongoing shortness of breath showed signs of heart and lung inflammation nearly a year after infection, even when standard tests were normal. (1)

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Adrienne Asher @asheradrienne.bsky.social · 13/05/2025

The Schmidt Initiative for #LongCovid announced a clinical trial to test AstraZeneca’s monoclonal antibody Sipavibart as a treatment for Long COVID. The randomized, placebo-controlled trial builds on earlier reports of Long COVID remission after monoclonal antibody use. silc.org/news/clinica...

silc.org

Clinical trial underway for potential Long Covid treatment - Schmidt Initiative for Long Covid

A clinical trial is underway to assess the effectiveness and safety of sipavibart, AstraZeneca’s long-acting monoclonal antibody designed to provide protection against Covid-19, as a potential treatme...

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Adrienne Asher @asheradrienne.bsky.social · 23/04/2025

According to the nutrition label, ASEA contains chloride (Cl) and sodium (Na). The active signaling molecules suspended in the saline solution are not listed. Do you know what they are?

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Adrienne Asher @asheradrienne.bsky.social · 23/04/2025

I’m sorry to read this. Take care.

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Adrienne Asher @asheradrienne.bsky.social · 23/04/2025

Also looking forward to no longer seeing NaziBarbie at some point.

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Adrienne Asher @asheradrienne.bsky.social · 23/04/2025

*white christo-fascist nation is what they’re trying to create, aka handmaid’s tale territory

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Adrienne Asher @asheradrienne.bsky.social · 23/04/2025

I ordered today (Trosciptions’ Just Blue). Assuming it will take a few days to arrive. Will start with 4mg, orally. I’ll let you know!

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Adrienne Asher @asheradrienne.bsky.social · 23/04/2025

What brand did you buy and how much did you take, how often?

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Adrienne Asher @asheradrienne.bsky.social · 22/04/2025

#Covid may increase the long-term risk of cancer, per a pre-print from UC San Francisco & NIH researchers. Scientists evaluated blood from almost 130 participants and found immune and metabolic damage in people with #LongCOVID. www.medrxiv.org/content/10.1...

medrxiv.org

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Adrienne Asher @asheradrienne.bsky.social · 22/04/2025

A study in The Journal of Virology found #Covid can persist in the semen for at least 6 months, and “the male genital tract may be a reservoir for the virus.” A Scientific Reports study of 900+ participants found #Covid was associated with lower sperm counts, reduced mobility, and DNA damage.

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Adrienne Asher @asheradrienne.bsky.social · 22/04/2025

Five years disabled w/ #LongCovid has turned me into a research machine as well as a guinea pig as I trial things that might help. Just over my latest flare, 16 days. Profound exhaustion is worst symptom. Stopped all supplements & am restarting one at a time, 3 mos. at a time, to test each.

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Adrienne Asher @asheradrienne.bsky.social · 22/04/2025

So I’ve been researching methylene blue for help with symptoms of #longCOVID, specifically exhaustion, but also brain fog. Used Google’s research AI (Gemini Deep Research), which can scrape info from the ‘net better/faster than I can. Here’s its results— gemini.google.com/app/da0b6eee...

gemini.google.com

‎Gemini

Bard is now Gemini. Get help with writing, planning, learning, and more from Google AI.

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Adrienne Asher @asheradrienne.bsky.social · 04/04/2025

Dr. Oz to run #Medicare and #Medicaid? This administration is a horror show of malignant stupidity.

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Adrienne Asher @asheradrienne.bsky.social · 02/04/2025

Thank you! Your speech was historic, brave, impassioned, needed.

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Adrienne Asher @asheradrienne.bsky.social · 28/03/2025

“Despite the important role that GABA normally plays in the brain, taking it orally does not significantly increase its levels in the brain … it’s not clear if it can cross the blood-brain-barrier. (Hepsomali, Front Neurosci 2020)” —found on ConsumerLab.com

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Adrienne Asher @asheradrienne.bsky.social · 25/03/2025

In lab models using whole blood, adding vitamin B12 reduced the overexpression of CCL11 by modifying its DNA methylation profile. This helped normalize pro-inflammatory and neuroprotective genes, indicating vitamin B12’s potential role in managing VCD. #LongCovid www.nature.com/articles/s41...

nature.com

Vitamin B12 as an epidrug for regulating peripheral blood biomarkers in long COVID-associated visuoconstructive deficit - Scientific Reports

Scientific Reports - Vitamin B12 as an epidrug for regulating peripheral blood biomarkers in long COVID-associated visuoconstructive deficit

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Adrienne Asher @asheradrienne.bsky.social · 25/03/2025

I have Long Covid, so as you can guess, I know the U.S. is doing very little to address it, and with this new prez things are even worse. Good times.

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Adrienne Asher @asheradrienne.bsky.social · 15/03/2025

My family is punished daily by Trump and Musk. We are—daily—plunged into chaos. Our retirement savings are evaporating, food costs are through the roof, our neighbors to the north and south of us now hate us. But sure, vote with the Nazis.

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Adrienne Asher @asheradrienne.bsky.social · 15/03/2025

I’ve read that not all kombucha is MCAS-friendly. Fresh, short-fermented, low-histamine versions may be better tolerated. Pairing with quercetin or DAO enzymes may help. All in all, it's certainly worth looking into, though carefully.

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Adrienne Asher @asheradrienne.bsky.social · 15/03/2025

A large nutritional intervention study involving #LongCovid patients showed that boosting the diet with plant-based foods, in combo with a specific lactobacillus probiotic and inulin prebiotic, reduced symptoms, improved gut health, and sped recovery. phyto-v.com

phyto-v.com

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Adrienne Asher @asheradrienne.bsky.social · 14/03/2025

Immune Helpers for #Covid, #LongCovid 🥒 Fermented Foods 🥦 High-Fiber Foods 🥬 Dark Leafy Greens 🍊 Citrus Fruits 🥜 Nuts and Seeds 🫚 Ginger 🧄 Garlic 🫐 Berries 🧀 Probiotic-Rich Foods 🦴 Bone Broth

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Reposted by Adrienne Asher

A Chronic Voice @achronicvoice.com · 14/03/2025

“Many who live with severe & #painful conditions can only manage 1 ‘big’ activity a day, especially if it involves leaving the house. If that day has a medical visit for example, everything pivots on that single activity”: buff.ly/3wXcPEN by @apainprincess.bsky.social #ChronicPain #ChronicFatigue

buff.ly

But You Look Good: Living with Disbelief of Invisible Illness and Pain

Each time we are told that we 'look good' or 'look well' by people who have little concept of even the lengths we have gone to just to connect with them at all, it carries with it

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Adrienne Asher @asheradrienne.bsky.social · 14/03/2025

Ginger Tea: Reduces neuroinflammation & enhances cognitive function. Blueberry Tea: High in antioxidants that combat oxidative damage in the brain. Cinnamon Tea: Improves blood sugar regulation, indirectly benefiting cognitive health. Black Teas: Improves focus & alertness. Rich in antioxidants.

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Adrienne Asher @asheradrienne.bsky.social · 14/03/2025

Chamomile Tea: Reduces stress & promotes relaxation. Holy Basil (Tulsi) Tea: Supports stress resilience & mental clarity. Matcha Tea: Enhances focus & brain function. Ashwagandha Tea: Reduces stress & promotes cognitive health. Rooibos Tea: Has protective anti-oxidative antioxidants. (more)

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Adrienne Asher @asheradrienne.bsky.social · 14/03/2025

Rosemary Tea: Boosts memory & sharpens focus with its aromatic compounds. Lemon Balm Tea: Calms the mind while supporting memory and focus. Peppermint Tea: Increases alertness & reduces mental fatigue. Gotu Kola Tea: Improves mental clarity & supports cognitive longevity. (more)

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