iiinova — where your digital self keeps evolving

Adrienne Asher @asheradrienne.bsky.social · 20/07/2025

89% of patients with Mast Cell Activation Syndrome (MCAS) had significant reduction in symptoms from GLP-1RAs. It is thought that these drugs stabilize mast cells and reduce inflammation. The authors recommend future randomized trials of these drugs in patients with #LongCOVID.

sciencedirect.com

Utility of Glucagon-Like-Peptide-1-Receptor Agonists in Mast Cell Activation Syndrome

Introduction: Mast cell (MC) activation syndrome (MCAS) is a collection of illnesses rooted in inappropriate MC activation with little to no neoplasti…

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Adrienne Asher @asheradrienne.bsky.social · 19/07/2025

Facinating article about Dr. Michael Peluso, MD, an infectious disease clinician and researcher, as well as the director and one of the co-creators of the large Long Term Impact of Infection with Novel Coronavirus (LIINC) project at UCSF. #LongCovid

healthrising.org

"Excited Every Day": Dr. Michael Peluso on LIINC, Long COVID and ME/CFS - Health Rising

Dr. Michael Peluso talks about the LIINC long COVID project, why he's excited every day about long COVID, and what he hopes the next 5 years will bring.

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Reposted by Adrienne Asher

Eric Topol @erictopol.bsky.social · 16/05/2025

On finding treatments for #LongCovid “What’s so sad here is people are so desperate, and we don’t have anything [of so many solid candidates] validated." gift link: www.washingtonpost.com/wellness/202...

washingtonpost.com

Long covid patients are desperate for treatments. These trials may help.

Some trials are focusing on drugs that target the immune system, which is affected by different pathways to long covid.

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Adrienne Asher @asheradrienne.bsky.social · 18/05/2025

Saw my new cardiologist a few days ago for #LongCovid issues (PEM, POTS). Two techs walk in, unmasked. I politely ask them to wear masks. “What?! Me?!” Yes, please. You. Why must this always be an issue? So tired of negotiating every. single. thing.

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Adrienne Asher @asheradrienne.bsky.social · 13/05/2025

Published research from Harvard’s Mass. General Hospital reveals that 8 weeks of regular mindfulness practice physically thickens brain regions involved in bodily awareness, while simultaneously reducing activity in the brain circuit responsible for mind-wandering and self-referential thinking. (1)

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Adrienne Asher @asheradrienne.bsky.social · 13/05/2025

Using single-cell analysis, scientists in China uncovered widespread changes in alternative polyadenylation of mRNA in brain-related cells after COVID. These disruptions may contribute to neurological and psychiatric symptoms observed in #LongCOVID patients. www.biorxiv.org/content/10.1...

biorxiv.org

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Adrienne Asher @asheradrienne.bsky.social · 13/05/2025

A preprint from Germany reports that 68 individuals with #LongCOVID had unusually active CD8+ T cells and elevated IL-3 levels. These immune signatures could help identify patients at risk and guide development of targeted therapies. www.sciencedirect.com/science/arti...

sciencedirect.com

Hyper-reactivity of CD8+ T cells and high expression of IL-3 correlates with occurrence and severity of Long-COVID

Following SARS-CoV-2 infection, some individuals develop Long-COVID-syndrome lasting for more than 3 months. We analyzed blood samples from patients w…

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Adrienne Asher @asheradrienne.bsky.social · 13/05/2025

A preprint study from Mount Sinai found that 57% of Respiratory Long COVID patients with ongoing shortness of breath showed signs of heart and lung inflammation nearly a year after infection, even when standard tests were normal. (1)

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Adrienne Asher @asheradrienne.bsky.social · 13/05/2025

The Schmidt Initiative for #LongCovid announced a clinical trial to test AstraZeneca’s monoclonal antibody Sipavibart as a treatment for Long COVID. The randomized, placebo-controlled trial builds on earlier reports of Long COVID remission after monoclonal antibody use. silc.org/news/clinica...

silc.org

Clinical trial underway for potential Long Covid treatment - Schmidt Initiative for Long Covid

A clinical trial is underway to assess the effectiveness and safety of sipavibart, AstraZeneca’s long-acting monoclonal antibody designed to provide protection against Covid-19, as a potential treatme...

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Adrienne Asher @asheradrienne.bsky.social · 22/04/2025

#Covid may increase the long-term risk of cancer, per a pre-print from UC San Francisco & NIH researchers. Scientists evaluated blood from almost 130 participants and found immune and metabolic damage in people with #LongCOVID. www.medrxiv.org/content/10.1...

medrxiv.org

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Adrienne Asher @asheradrienne.bsky.social · 22/04/2025

A study in The Journal of Virology found #Covid can persist in the semen for at least 6 months, and “the male genital tract may be a reservoir for the virus.” A Scientific Reports study of 900+ participants found #Covid was associated with lower sperm counts, reduced mobility, and DNA damage.

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Adrienne Asher @asheradrienne.bsky.social · 22/04/2025

Five years disabled w/ #LongCovid has turned me into a research machine as well as a guinea pig as I trial things that might help. Just over my latest flare, 16 days. Profound exhaustion is worst symptom. Stopped all supplements & am restarting one at a time, 3 mos. at a time, to test each.

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Adrienne Asher @asheradrienne.bsky.social · 22/04/2025

So I’ve been researching methylene blue for help with symptoms of #longCOVID, specifically exhaustion, but also brain fog. Used Google’s research AI (Gemini Deep Research), which can scrape info from the ‘net better/faster than I can. Here’s its results— gemini.google.com/app/da0b6eee...

gemini.google.com

‎Gemini

Bard is now Gemini. Get help with writing, planning, learning, and more from Google AI.

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Adrienne Asher @asheradrienne.bsky.social · 04/04/2025

Dr. Oz to run #Medicare and #Medicaid? This administration is a horror show of malignant stupidity.

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Adrienne Asher @asheradrienne.bsky.social · 25/03/2025

In lab models using whole blood, adding vitamin B12 reduced the overexpression of CCL11 by modifying its DNA methylation profile. This helped normalize pro-inflammatory and neuroprotective genes, indicating vitamin B12’s potential role in managing VCD. #LongCovid www.nature.com/articles/s41...

nature.com

Vitamin B12 as an epidrug for regulating peripheral blood biomarkers in long COVID-associated visuoconstructive deficit - Scientific Reports

Scientific Reports - Vitamin B12 as an epidrug for regulating peripheral blood biomarkers in long COVID-associated visuoconstructive deficit

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Adrienne Asher @asheradrienne.bsky.social · 15/03/2025

A large nutritional intervention study involving #LongCovid patients showed that boosting the diet with plant-based foods, in combo with a specific lactobacillus probiotic and inulin prebiotic, reduced symptoms, improved gut health, and sped recovery. phyto-v.com

phyto-v.com

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Adrienne Asher @asheradrienne.bsky.social · 14/03/2025

Immune Helpers for #Covid, #LongCovid 🥒 Fermented Foods 🥦 High-Fiber Foods 🥬 Dark Leafy Greens 🍊 Citrus Fruits 🥜 Nuts and Seeds 🫚 Ginger 🧄 Garlic 🫐 Berries 🧀 Probiotic-Rich Foods 🦴 Bone Broth

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Reposted by Adrienne Asher

A Chronic Voice @achronicvoice.com · 14/03/2025

“Many who live with severe & #painful conditions can only manage 1 ‘big’ activity a day, especially if it involves leaving the house. If that day has a medical visit for example, everything pivots on that single activity”: buff.ly/3wXcPEN by @apainprincess.bsky.social #ChronicPain #ChronicFatigue

buff.ly

But You Look Good: Living with Disbelief of Invisible Illness and Pain

Each time we are told that we 'look good' or 'look well' by people who have little concept of even the lengths we have gone to just to connect with them at all, it carries with it

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Adrienne Asher @asheradrienne.bsky.social · 14/03/2025

Teas for brain health. #LongCovid #Brainfog Green Tea: Contains L-theanine & caffeine; improves focus & reduces mental fatigue. Turmeric Tea: Combines anti-inflammatory & neuroprotective properties. Ginkgo Biloba Tea: Enhances blood flow to the brain, improving concentration & memory. (more)

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Adrienne Asher @asheradrienne.bsky.social · 14/03/2025

#LongCovid brain fog? Here’s a list of foods that support brainpower. (Source: Harvard Health) www.health.harvard.edu/healthbeat/f...

health.harvard.edu

Foods linked to better brainpower - Harvard Health

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Adrienne Asher @asheradrienne.bsky.social · 11/03/2025

#LongCovid & electrolytes—Results showed a significant association between electrolyte supplementation & improvements in heart rate variability parameters. Electrolyte supplementation also linked to reduction in premature contractions & improved quality of life. www.frontiersin.org/journals/car...

frontiersin.org

Frontiers | Association between electrolyte supplementation and cardiac injury in long COVID-19

Objective: This study aimed to investigate the association between electrolyte supplementation and cardiac injury in long coronavirus disease 2019 (COVID-19)...

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Adrienne Asher @asheradrienne.bsky.social · 05/03/2025

We Need Mandatory Masking in Healthcare, and We Need it Now! Healthcare facilities should set the tone when it comes to masking. They should help patients protect themselves from #Covid and other threats. Instead they push droplet dogma and put lives at risk

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Adrienne Asher @asheradrienne.bsky.social · 04/03/2025

- #COVID winter wave declining more slowly than previous years -Current vaccines very effective against severe outcomes + reduce transmission -Adults 65+ should consider getting 2nd 2024-2025 vax after 6 mos., or sooner if big plans/events/risks -COVID can accelerate coronary artery plaque growth

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Adrienne Asher @asheradrienne.bsky.social · 04/03/2025

We’ll be seeing some grim years for #LongCovid research under Trump. As reported in The Sick Times, STAT News: -Issued and executive order to terminate the Secretary's Advisory Committee on Long COVID -Removed Long COVID info and data from federal websites -Is attacking research at the NIH

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Adrienne Asher @asheradrienne.bsky.social · 04/03/2025

Japanese researchers have developed a peptide that prevents #COVID19 by binding to spike proteins. Inexpensive, easily synthesized, potentially side-effect free, can be stored at room temperature and administered through inhalation. www.japantimes.co.jp/news/2025/01...

japantimes.co.jp

Japanese researchers develop peptide preventing COVID-19 infections

The peptide, which is a short chain of amino acids, has shown effectiveness in experiments involving various coronavirus strains.

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Adrienne Asher @asheradrienne.bsky.social · 02/03/2025

PubMed is down. But a similar European site is available. Since I use PubMed for the majority of my #LongCovid and #ME/CFS research, I’ll be switching until America is back online, four years from now. europepmc.org

europepmc.org

Europe PMCHome - Europe PMC

Europe PMC is an archive of life sciences journal literature.

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Adrienne Asher @asheradrienne.bsky.social · 28/02/2025

#LongCovid brain fog? Swimming boosts memory. A Journal of Physiology study found swimming strengthens neural pathways essential for memory and learning. Buoyancy reduces stress on the body while significantly increasing circulation, oxygen, and nutrients to support memory and cognitive function.

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Adrienne Asher @asheradrienne.bsky.social · 25/02/2025

A recent study found inspiratory training improved autonomic functioning, sleep, pain, heart rate variability, and resting heart rate in #ME/CFS and #LongCovid, and even improved the distance the participants covered in the 6-minute walk test. www.healthrising.org/blog/2024/12...

healthrising.org

Better Breathing for Better Health? ME/CFS and Long COVID Inspiratory Breathing Study Shows Promise - Health Rising

An ME/CFS and Long COVID inspiratory breathing study improve autonomic nervous system functioning and improves sleep and other symptoms.

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Adrienne Asher @asheradrienne.bsky.social · 24/02/2025

Researchers have identified a nanobody that effectively neutralizes all tested Omicron subvariants, SARS-CoV-1, & pangolin coronavirus. This has potential as an intranasal prophylactic & could help with development of a universal vaccine against current & future sub-viruses. -Ruth Ann Crystal, MD

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Adrienne Asher @asheradrienne.bsky.social · 23/02/2025

Horrific News: Health and Human Services federal advisory committee on #LongCOVlD was ordered on 2/19/25 to terminate within 14 days. Link to HHS site: bit.ly/4ia0yz0 Link to White House order that rejects our fight against Long COVlD: bit.ly/4h6TTVn Write to your representatives! Take action!

bit.ly

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Adrienne Asher @asheradrienne.bsky.social · 22/02/2025

When #disability becomes a cautionary tale, it segues to ableism. It’s then used as a symbol of fear mongering, shoring up notions of able-bodiedness, whiteness, & nationhood, to protect the able-bodied who remain. This leads to a xenophobic or fascist environment. -Sunaura Taylor #LongCovid #ME/CFS

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Adrienne Asher @asheradrienne.bsky.social · 22/02/2025

Harriet McBryde Johnson: disabled people take conditions that people would never ask for and make beautiful, thriving lives out of them. We have to remind ourselves that there will always be disabled people living thriving lives. There will always be moments of beauty and joy. #LongCovid #ME/CFS

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Adrienne Asher @asheradrienne.bsky.social · 22/02/2025

Handy info — Pacing and Management Guide for people living with #ME/CFS and #LongCovid

meaction.net

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Reposted by Adrienne Asher

Piglet @piglet.bsky.social · 18/02/2025

"you don't look sick."

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Adrienne Asher @asheradrienne.bsky.social · 18/02/2025

A RECOVER study finds that #longCOVID produces more people with #ME/CFS than previously thought. Plus, HealthRising took a deep, deep dive into RECOVER and came to the surprising conclusion that the huge Long Covid initiative may end up being quite helpful. www.healthrising.org/blog/2025/01...

healthrising.org

An Explosion of ME/CFS in the US + The Real Difference RECOVER May Make In Long COVID - Health Rising

Long COVID increases the prevalence of ME/CFS in the US fifteenfold plus a deep dive into RECOVER's testing program suggests it might help a lot.

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Adrienne Asher @asheradrienne.bsky.social · 16/02/2025

Webpages on #LongCOVID disability accommodations, incl ADA resources, have been removed from the Dept of Labor website following Trump purges. Disability advocates say legal protections remain, but this makes it harder for us to access crucial info about rights and workplace accommodations.

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Adrienne Asher @asheradrienne.bsky.social · 16/02/2025

Last year, Rob Wust’s lab wrote a paper in Nature magazine showing that muscle abnormalities worsen after PEM in people with #LongCOVID. This week, Ranque et al. posted a reply stating they believe the muscle abnormalities are due to deconditioning rather than exercise-induced muscle damage. 1/2

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Reposted by Adrienne Asher

MaskTogetherAmerica @togetherwemask.bsky.social · 15/02/2025

"Individuals who are hospitalized, who are pretty sick, or who had bird exposure — we are subtyping," said Hamilton County Public Health Medical Director Dr. Stephen Feagins. "It's a matter of time until we see some more human cases. And so we want to be looking for it rather than waiting for it."

wlwt.com

Cincinnati-area doctors on lookout for symptoms that could suggest bird flu in people

This week, for the first time in Ohio history, a man living a little more than an hour northwest of Dayton tested positive for bird flu.

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