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Reposted by A.S.Brumm

PLOS Biology @plosbiology.org · 26/08/2026

Neuromesodermal progenitor cells generate multiple tissues. This study by @abinagui.bsky.social @edinuni-irr.bsky.social @osvaldo-chara.bsky.social @cellysally.bsky.social &co maps their functional heterogeneity and links TF expression thresholds to #cellFate. 🧪 #AcademicSky plos.io/4xWA8Ze

3D spatial organization of neural and mesodermal lineages in the developing embryo.

A 3D image projection of a day 7 mouse embryo, stained for neural SOX2 (magenta), mesodermal TBXT (green) and DAPI (blue) revealing the precise spatial organization of neural and mesodermal transcription factors that govern body axis elongation.
Credit: Filip J. Wymeersch
License Agreement: The copyright holder agrees to publish this image under the Creative Commons Attribution 4.0 International License (CC-BY 4.0).
Note: This image was acquired by confocal microscopy. No generative AI was used in data acquisition or processing.

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nvargesson.bsky.social @nvargesson.bsky.social · 25/03/2026

Honoured to have been awarded the 2026 British Society for Developmental Biology Lewis Wolpert Medal - means so much; as i was Lewis’s last PhD student,recognition for continuing his legacy of public engagement & impact of our research on Thalidomide & Primodos survivors. bsdb.org/2026/03/24/2...

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Reposted by A.S.Brumm

Niakan Lab @niakanlab.bsky.social · 30/09/2025

One of our favourite tabs is Resources: we're listing all of our datasets, codes, beginning to upload and make accessible raw imaging data and lab protocols. Please check it out, we hope this is useful! niakanlab.com/resources/

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Teresa Rayon @trayon.bsky.social · 24/07/2025

Found this unbelievably accurate “integrated stem cell model” by JA Thomson in 1996 of marmoset ESCs 🐒 pubmed.ncbi.nlm.nih.gov/8828827/ The simplest protocol one can think of built quite remarkable structures !?!?

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Reposted by A.S.Brumm

PLOS Biology @plosbiology.org · 16/07/2025

Measuring properties of individual cells in relation to their neighbors in 3D tissues is challenging. @cellysally.bsky.social &co develop a computational toolkit to facilitate this, analyzing developmental patterning in mouse, chick & #Drosophila #embryo @plosbiology.org 🧪 plos.io/4lQMeNu

Patterning of cell identities in the posterior E8.5 mouse embryo. Co-expression of mesoderm marker TBXT (blue) and neural marker SOX2 (green) identifies cells in the neuromesodermal (NMP) progenitor region at the intersection of their respective gene expression gradients. TBX6 (red) marks paraxial mesoderm and also marks sporadic mesoderm-committed cells emerging within the NMP region. LAMINB1 (white) marks the nuclear envelope of all cells. Credit: Matthew French.

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Biology Open @biologyopen.bsky.social · 01/07/2025

Can peer review be done faster, without compromising on quality? Biology Open has embarked on an exciting experiment to find out - Editor-in-Chief Dan Gorelick @danielgorelick.bsky.social explains. www.youtube.com/watch?v=Tt5h...

youtube.com

Why is Biology Open's Fast & Fair peer review initiative exciting?

YouTube video by The Company of Biologists

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Reposted by A.S.Brumm

Sally Lowell @cellysally.bsky.social · 24/06/2025

Join us! This will be a great meeting.

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Reposted by A.S.Brumm

Katherine Brown @katherine-brown.bsky.social · 25/03/2025

If you’re a PhD or postdoc developmental biologist in the UK who cares about the field and the community, please nominate yourself to join the BSDB committee. Great opportunity to get involved, have real input and give back to the community @bsdb.bsky.social #biologists100

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A.S.Brumm @asbrumm.bsky.social · 24/03/2025

Excited to share how we use neighbour labelling to investigate cell fate decisions in neuromesodermal progenitors. Find me at Poster 165 @biologists.bsky.social #biologists100.

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Jen Annoh @jens-cells.bsky.social · 17/03/2025

🧪Attending your first scientific #conference? Thinking about what to pack, or just looking to make sure you prepared all the essentials? Have a look at The Beginner’s Guide to Scientific Conferences I got to publish for @the-node.bsky.social, out now! ☺️☺️ thenode.biologists.com/the-beginner...

thenode.biologists.com

the-beginners-guide-to-scientific-conferences

The Beginners Guide to Scientific Conferences

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Reposted by A.S.Brumm

Babraham Institute @babrahaminst.bsky.social · 26/02/2025

Have you been following the work of the HDBI - the Human Developmental Biology Initiative? A lay summary of a recent paper from researchers involved in the HDBI is now available, written by the paper's first author @asbrumm.bsky.social hdbi.org/human-epibla... #Embryos #HumanDevelopment

Text reads: The ability of cells in early human embryos to become more specialised does not depend on a process previously thought necessary from work in stem cell models.

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André Dias @dias-andre.bsky.social · 13/01/2025

www.biorxiv.org/content/10.1... Here we explore the role of #Wnt and #Nodal signalling during mammalian gastrulation using #gastruloids. Building on the work of many labs, we propose that antagonistic signalling-dependent #modularity in the PS establishes the early mammalian body plan.

biorxiv.org

A temporal coordination between Nodal and Wnt signalling governs the emergence of the mammalian body plan

Nodal and Wnt signalling play an important role in the emergence of the mammalian body plan, primarily by orchestrating gastrulation and primitive streak formation. While the literature suggests that ...

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A.S.Brumm @asbrumm.bsky.social · 20/11/2024

Special shout-out to Michele Marass, our outstanding steward through the turbulent waters that is the review process.

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A.S.Brumm @asbrumm.bsky.social · 20/11/2024

I’m grateful for the continued support from the Niakan Lab, and our collaborators in the labs of L. Vallier, P. Rugg-Gunn, and C. Hill, who made this work possible. 9/10

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A.S.Brumm @asbrumm.bsky.social · 20/11/2024

These data suggest differences in the signalling requirements regulating pluripotency in the pre-implantation human epiblast compared with existing human embryonic stem cell culture. 8/10

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A.S.Brumm @asbrumm.bsky.social · 20/11/2024

Transcriptional analysis of A8301-treated human blastocysts indicated that NANOG transcription did not decrease under NODAL signalling inhibition, in contrast to naïve human embryonic stem cells in t2iLifGo conditions pubmed.ncbi.nlm.nih.gov/34463252/ 7/10

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A.S.Brumm @asbrumm.bsky.social · 20/11/2024

A8301 treatment throughout human blastocyst development from 5 to 7 days post fertilisation did not impact the number of cells expressing epiblast markers NANOG, SOX2, KLF17 or primitive endoderm marker GATA4. 6/10

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A.S.Brumm @asbrumm.bsky.social · 20/11/2024

We next characterised three NODAL signalling inhibitors, yet only A8301 reliably inhibited SMAD2/3 phosphorylation and nuclear accumulation. The required high concentration of A8301 also inhibited BMP signalling, found in the primitive endoderm of human blastocysts. 5/10

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A.S.Brumm @asbrumm.bsky.social · 20/11/2024

We found that NANOG expression emerges in the inner cell mass of human blastocysts at 5 days post fertilisation, in the absence of NODAL signalling activity. NODAL signalling then becomes active throughout the pluripotent epiblast and extra-embryonic primitive endoderm. 4/10

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A.S.Brumm @asbrumm.bsky.social · 20/11/2024

To characterise NODAL signalling activity, we optimised an immunofluorescence protocol to detect the intracellular effectors SMAD2/3, which become phosphorylated and accumulate in the nucleus upon ligand binding. See also Kruger et al doi.org/10.1242/dev.... 3/10

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A.S.Brumm @asbrumm.bsky.social · 20/11/2024

In vitro, NODAL regulates pluripotency, by promoting NANOG expression, as shown by Ludovic Vallier, AnnaOsnato and others. We thus wondered whether NODAL signalling activity was active in pre-implantation human development and involved in human pluripotency in vivo. 2/10

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A.S.Brumm @asbrumm.bsky.social · 20/11/2024

In my PhD work, published last Monday, we show that both NODAL and BMP signalling are active in the human blastocyst, but NODAL signalling is not required to initiate or maintain the human pluripotent epiblast. 1/10

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A.S.Brumm @asbrumm.bsky.social · 20/11/2024

Thank you so much @cellysally.bsky.social - great slogan! I'll cross-post my Twitter thread below.

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