Sign in

Asaf Levy

@asaflevylab.bsky.social
1.8K followers 194 following 542 posts

Interested in computational biology, microbial toxins, plant microbiome, and microbial adaptation to different hosts. PI at the Hebrew University of Jerusalem. www.asaflevylab.com Expressing my personal opinions.

PostsRepliesMedia
Asaf Levy @asaflevylab.bsky.social · 05/10/2026
... and the days Fig. 1 of a Science paper is an ugly pairwise sequence alignment !!!
020
Asaf Levy @asaflevylab.bsky.social · 05/10/2026
I love the vision at the end of Nagel et al. Science 2002: "the ability of ChR1 to mediate a large light-switched H+ conductance in oocytes holds promise for the use of ChR1 as a tool for measuring and/or manipulating electrical and proton gradients across cell membranes, simply by illumination."
science.org
Channelrhodopsin-1: A Light-Gated Proton Channel in Green Algae
Phototaxis and photophobic responses of green algae are mediated by rhodopsins with microbial-type chromophores. We report a complementary DNA sequence in the green alga Chlamydomonas reinhardtiithat ...
151
Reposted by Asaf Levy
Florent Waltz @florentwaltz.bsky.social · 05/10/2026
Huge congratulations to all three Nobel Laureates, and especially Peter Hegemann! 👏 His seminal work on the green alga Chlamydomonas 🦠 laid the foundation for optogenetics. Thank you for putting Chlamy in the spotlight! ✨ Proof that groundbreaking discoveries don't always come from animal models! 🔬
Chlamydomonas cells
023378
Reposted by Asaf Levy
International Society for Molecular Plant-Microbe Interactions @ismpmi.bsky.social · 01/10/2026
Did you miss yesterday's fantastic Legends of IS-MPMI webinar with @jonathandgjones.bsky.social? You can watch the whole thing on our YouTube channel! 👇 youtu.be/yynU5Bu8BRM?...
youtu.be
Road to Jeju Webinar by Jonathan Jones. Recognizability and Recognize-ability...
YouTube video by IS-MPMI
176
Asaf Levy @asaflevylab.bsky.social · 01/10/2026
Correction: the young victim was found dead and I don't know the reason for her death. I assumed she took her life.
000
Asaf Levy @asaflevylab.bsky.social · 01/10/2026
It is also highly disturbing that it took my university years to handle the sexual harassment complaint.
100
Asaf Levy @asaflevylab.bsky.social · 01/10/2026
en.wikipedia.org/wiki/Karim_A... This guy is now employed as a Directeur de Recherche with the CNRS, situated at Sorbonne University after leaving the Hebrew U. The person he sexually harassed for years until she complained, his student, Johanna Kristina Steinmeyer, committed suicide 6 months ago.
en.wikipedia.org
Karim Adiprasito - Wikipedia
130
Asaf Levy @asaflevylab.bsky.social · 30/09/2026
Also AI models!
000
Asaf Levy @asaflevylab.bsky.social · 30/09/2026
In October we are starting year 8 (I think) of the virtual microbiology journal club (on Zoom) with fantatstic speakers, as usual. Most talks are about bacteria. If you (PIs, trainees, anyone interested in science) want to be included in the mailing list - shoot me an email. alevy@mail.huji.ac.il
023
Asaf Levy @asaflevylab.bsky.social · 29/09/2026
that was toxic in bacterial cyto/periplasm and in yeast cells. Mutations in the metal binding pocket destroyed its activity. This is another fun collaboration with my friend Dr. Netanel Tzarum. Stay tuned for another paper resulting from this collaboration which will be published in a few days.
000
Asaf Levy @asaflevylab.bsky.social · 29/09/2026
We observed that T6SS effectors tend to be longer, more hydrophilic, charged, and ordered, and to reside next to or fused to T6SS genes significantly more than non-T6Es. Common protein domains are depleted from effectors. Another new effector is likely a non-specific metalloprotease
100
Asaf Levy @asaflevylab.bsky.social · 29/09/2026
demonstrating a moon-like structural phenotype. You can observe the cell wall unipolar accumulation and degradation in blue. We didn't expect to E. coli looking so weird. We provide predictions of 19,958 T6SS effector candidates in 2,559 T6SS-encoding bacterial genomes.
110
Asaf Levy @asaflevylab.bsky.social · 29/09/2026
Chryseobacterium, showed a beautiful phenotype. This toxin, that we named the "moon toxin", targets the peptidoglycan. When expressed in E. coli, it quickly leads to spherical aggregated cells, with inner membrane separation, and gradual peptidoglycan degradation in a unipolar manner,
110
Asaf Levy @asaflevylab.bsky.social · 29/09/2026
Our new preprint is out. www.biorxiv.org/content/10.6... We applied an XGBoost algorithm with genomic and biochemical features to detect all T6SS effectors in bacterial genomes. Next, we validated 3 novel effectors that serve as antibacterial or anti-euk toxins. One of the effectors, from
biorxiv.org
162
Asaf Levy @asaflevylab.bsky.social · 28/09/2026
I found this paper from 2002 about plant-fungal symbiosis which enables both partners to grow above 45C (!) in geothermal soils in Lassen Volcanic and Yellowstone National Parks. As far as I understand te genetic basis of this thermotolerance is still unknown. www.science.org/doi/10.1126/...
science.org
Thermotolerance Generated by Plant/Fungal Symbiosis
All plants studied in natural ecosystems are symbiotic with fungi (1), which obtain nutrients while either positively, negatively, or neutrally affecting host fitness (2). Plant adaptation to selectiv...
150
Reposted by Asaf Levy
Yasin Dagdas @plantophagy.bsky.social · 24/09/2026
Congrats @mayavoichek.bsky.social @juliusbrennecke.bsky.social & everyone involved!!!
1243
Reposted by Asaf Levy
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 20/09/2026
Experimental evolution of root-associated microbial communities www.biorxiv.org/content/10.64898/20…
01010
Reposted by Asaf Levy
Omri Finkel עמרי عُمري @finkel-lab.bsky.social · 17/09/2026
Michal Breker and I started our labs around the same time. Michal studies Chlamydomonas, and I plant microbiota. We joined forces to see how our bugs interact. This led us down a long and winding road, with 3 amazing PhDs and help from many friends. This is the first product of this collaboration.
biorxiv.org
Conserved inhibitory mechanisms of root-associated bacteria towards Arabidopsis thaliana and Chlamydomonas reinhardtii
Soil bacteria colonize plants without causing visible disease, yet many suppress host growth. The prevalence and evolutionary reach of this cryptic inhibition are unknown, because phenotyping hundreds...
01411
Asaf Levy @asaflevylab.bsky.social · 16/09/2026
Interesting finding by Dianne Newman's group from a few months ago: Elevated antibiotic resistance in soils under drought www.nature.com/articles/s41...
nature.com
Drought drives elevated antibiotic resistance across soils - Nature Microbiology
Drought conditions in soil systems lead to elevated concentrations of natural antibiotics, as well as the enrichment of antibiotic-resistant microorganisms, highlighting a link between climate and the...
010
Asaf Levy @asaflevylab.bsky.social · 13/09/2026
Nice experimental evolution work from @cascaleslab.bsky.social on the mechanisms by which T6SS is lost during evolution when present with T6SS-immune competing bacteria, compared to its maintenance when competitors are T6SS susceptible. www.cell.com/current-biol...
cell.com
Experimental evolution reveals genetic routes for adaptive loss of the antibacterial type VI secretion system
Taillefer et al. show that a bacterial type VI secretion system is lost or attenuated during experimental evolution when it provides no competitive advantage but is maintained in the presence of susceptible competitors. T6SS inactivation arises through diverse regulatory and structural mutations, revealing how ecological context shapes antibacterial weapon evolution.
083
Asaf Levy @asaflevylab.bsky.social · 12/09/2026
Happy new Jewish year to the Levy lab friends, collaborators, and Reviewers #2 around the world. May the next one will be much more peaceful. (Pic from lab's bday in Palmachim beach 2 days ago).
081
Asaf Levy @asaflevylab.bsky.social · 08/09/2026
PISA results are alarming. (Graph from The Economist).
041
Asaf Levy @asaflevylab.bsky.social · 06/09/2026
Our friend the @shlezingerlab.bsky.social is hiring! Highly recommended. Working on the fascinating unknown world of mycoviruses. Her 1st postdoc, Marina Campos Rocha, just started her independent academic position.
063
Asaf Levy @asaflevylab.bsky.social · 06/09/2026
Cool stuff from the Sorek lab on the functional connection between anti-phage bacterial immunity and plant immunity and the ways to manipulate these. 1st author: Dr. Ohad Roth @soreklab.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
Plant pathogens cleave 2′cADPR to suppress TIR immune signaling
Small molecules produced by TIR (Toll-interleukin-1 receptor) domains are essential for plant immune signaling. A central TIR-derived signal is 2ʹcADPR, a cyclic ADP-ribose (ADPR) molecule that is gen...
080
Asaf Levy @asaflevylab.bsky.social · 06/09/2026
journals.plos.org/plospathogen...
journals.plos.org
Acidic and alkaline conditions enhance Staphylococcus aureus α-toxin pore formation and cytotoxicity
Author summary Staphylococcus aureus is a bacterium that can cause severe invasive infections. S. aureus produces many toxins during infection, of which α-toxin (AT) is clinically relevant. AT is a po...
020
Asaf Levy @asaflevylab.bsky.social · 01/09/2026
check out Chlorophyll levels in Nasa's satellite eyes.nasa.gov/apps/earth/#...
eyes.nasa.gov
Eyes on the Earth - NASA/JPL
Welcome to NASA's Eyes, a way for you to learn about your home planet, our solar system, the universe beyond and the spacecraft exploring them.
000
Asaf Levy @asaflevylab.bsky.social · 01/09/2026
extreme chlorophyll values are marked in red, source: Matan Hodorov on X.
000
Asaf Levy @asaflevylab.bsky.social · 01/09/2026
Pretty amazing ecological effect. Microalgae from the Nile river delta are currently clogging Israel's desalination plants in the Mediterranean, disrupting agriculture in desert which is based on desalinated water. @bejalab.bsky.social
310
Asaf Levy @asaflevylab.bsky.social · 31/08/2026
RIP
1114
Asaf Levy @asaflevylab.bsky.social · 29/08/2026
given the monkey business in the field this is news
000
Asaf Levy @asaflevylab.bsky.social · 29/08/2026
They can afford subscription to NYT...
030
Asaf Levy @asaflevylab.bsky.social · 29/08/2026
Amazing achievement to Bonnie Bassler. The medal is shared with the most creative scientists ever lived since the 18th century.
000
Asaf Levy @asaflevylab.bsky.social · 27/08/2026
A nice ecological story from Nancy Moran's lab. www.nature.com/articles/s41...
nature.com
Colibactin produced by a honeybee gut symbiont mediates pathogen defence - Nature Microbiology
A colibactin-producing symbiont in honeybee guts defends against opportunistic pathogens and confers protection.
063
Asaf Levy @asaflevylab.bsky.social · 25/08/2026
For nearly 20 years I have used this pic as my FB profile image and already forgot where it was taken by my wife. But today, while hiking with my kids in Aigüestortes i Estany de Sant Maurici National Park (Spain) I found the exact corner and my sons reproduced it.
011
Asaf Levy @asaflevylab.bsky.social · 07/08/2026
Elections are on Oct. "A sane government is required"
030
Reposted by Asaf Levy
Itai Yanai @itaiyanai.bsky.social · 31/07/2026
Science funding has still not reached gender equality: "Projects led by male PIs received roughly twice the mean funding compared to female PIs." www.sciencedirect.com/science/arti...
01112
Asaf Levy @asaflevylab.bsky.social · 26/07/2026
The pope promotes people to saints after having evidence for their miracles. Pope Leo already canonized 9 people in his short term. Pope Francis: more than 60. And I am thinking about this graph
030
Asaf Levy @asaflevylab.bsky.social · 22/07/2026
This is a painful one.
010
Asaf Levy @asaflevylab.bsky.social · 22/07/2026
Take another look at the ranking. The last ones are really poor places (Chad, South Sudan, Lesotho...). Basically where you get sick and die, if I understand correctly.
001
Asaf Levy @asaflevylab.bsky.social · 22/07/2026
Nice. I didn't know him. Thanks for sharing!
110
Asaf Levy @asaflevylab.bsky.social · 22/07/2026
@nachmiasnimrod.bsky.social
000
Asaf Levy @asaflevylab.bsky.social · 22/07/2026
The only people who ever loved war for long were profiteers, generals, staff officers, and whores. They all had the best and finest time of their lives and most of them made the most money they had ever made. Hemingway, 1936
121
Asaf Levy @asaflevylab.bsky.social · 17/07/2026
All the young dudes!
110
Asaf Levy @asaflevylab.bsky.social · 17/07/2026
The year is 2500 Technology enables sampling of the entire ecosystem at atom resolution within milliseconds. Analysis is done using ImageJ
060
Asaf Levy @asaflevylab.bsky.social · 16/07/2026
We're recruiting a fungal biologist to our friendly department at the Hebrew University of Jerusalem, Rehovot, Israel. For details contact our chair. Talented non-Israli applicants are welcome to apply. See below.
01215
Asaf Levy @asaflevylab.bsky.social · 14/07/2026
@torreslab.bsky.social
020
Asaf Levy @asaflevylab.bsky.social · 14/07/2026
GRC toxins: France vs. Spain game
170
Asaf Levy @asaflevylab.bsky.social · 11/07/2026
Acadia NP
020
Asaf Levy @asaflevylab.bsky.social · 10/07/2026
(Enough with dad jokes)
000
Asaf Levy @asaflevylab.bsky.social · 10/07/2026
A cool work from Ilya and Rotem on the 'damage-associated molecular pattern' that bacteria sense to detect phage attack (DNA degradation leading to increase in methylated nucleotides) and the immune response as abortive infection. www.science.org/doi/10.1126/...
science.org
Bacteria sense virus-induced genome degradation via methylated mononucleotides
Phages often degrade the genome of their bacterial host to individual nucleotides. Here we describe Metis, a bacterial defense system that directly senses phage-mediated host genome degradation. Metis...
0140