iiinova — where your digital self keeps evolving

Reposted by Arthur Lensen

Enninga Lab @enningalab.bsky.social · 22/09/2025

Time for some insights into our latest #preprint Using cryo–electron tomography, we peeked inside different #Mtuberculosis strains, and a couple of other mycobacteria.🧐 Surprise: some species, especially the host-adapted ones, build intracytoplasmic membranes (we call them MIMs)! 🦠

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Arthur Lensen @arthurlensen.bsky.social · 18/09/2025

After years of hard work and months of growing MTB @camimille.bsky.social submitted her story ! Check this out if you wanna discover new intrabacterial structures and their function ! 🦠🔬✨

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Arthur Lensen @arthurlensen.bsky.social · 08/07/2025

Very happy to have participated in #ETOX2025 ! Very nice science, amazing crowd and wonderful place ! I was happy to present a poster of my work to a lot of old and new friends and colleagues. Thanks to the organizer for all their work and I hope to come back in two years !

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Reposted by Arthur Lensen

David Albesa @davidalbesa.bsky.social · 06/07/2025

A massive thank you to all the incredible participants and speakers who made ETOX 2025 in the Basque Country an unforgettable event! Your insights, discussions, and passion for bacterial protein toxins have truly advanced the field. We're already looking forward to next time! #ETOX2025

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Reposted by Arthur Lensen

Institut Pasteur | 130 years of biomedical research @pasteur.fr · 26/05/2025

Zoom into a human cell infected by Shigella, the bacteria behind dysentery. Using cryo-EM, @leaswistak.bsky.social and team revealed how it pierces cells with molecular syringes. Stunning science at the nanoscale. @enningalab.bsky.social @jytinevez.bsky.social @nanoimaging.bsky.social #CryoEM

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Reposted by Arthur Lensen

PLOS Biology @plosbiology.org · 06/05/2025

How do intracellular #bacteria breach vacuoles to enter the host cytosol? @leaswistak.bsky.social @matthijnvos.bsky.social @enningalab.bsky.social &co show that #Shigella uses its T3SS system to damage endomembranes via mechanoporation to initiate cytosolic access @plosbiology.org 🧪 plos.io/4jXrr9Z

Left: Group of three T3SS localizing in the same zone of the bacteria surface. T3SS n°1 and 2 contact, deform, and perforate the vacuole membrane at the same spot. T3SS n°1 needle (83 nm) is long and seems to deviate from basal body axis showing that strong constraints between T3SS and the vacuole at are play. The locally relaxed vacuole to bacteria space (~50–55 nm) potentially limits additional damage by the T3SS n°3 needle (56 nm) that only slightly deforms the membrane. Right: Model of initial vacuolar membrane breaching by T3SS-induced mechanoporation. Shigella actively enters host cells in a specialized endomembrane compartment, the vacuole, that is rapidly injured and ruptured for cytosolic access. After host cell entry, the vacuole membrane is intact and tightly juxtaposed to the surface of Shigella, permitting contact between T3SSs and the endomembrane. In the authors’ proposed model, vacuole membrane injury is supported both by the vacuole tightness and the length of individual T3SSs.

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Arthur Lensen @arthurlensen.bsky.social · 24/01/2025

No one mourns the Wicked ! Some 🟢Elphaba🟢 colored actin and cytosolic 🟣Glinda magic🟣. Steer all this with 🔵 Hoescht, Shigella and 🟡 Rab35 (PMID : 38568808 😉) and you get these sparkling cells, perfect for #FluorescenceFriday

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Reposted by Arthur Lensen

Institut Pasteur | 130 years of biomedical research @pasteur.fr · 16/01/2025

The Institut Pasteur has decided to leave X (formerly Twitter) to join BlueSky! 🦋 The Institut Pasteur made this decision due to several serious issues observed on the X platform since its acquisition. Join us here to continue advocating for science. www.pasteur.fr/en/home/pres...

pasteur.fr

Institut Pasteur decides to leave X

The Institut Pasteur, a research organization which for more than 130 years has been committed to tackling infectious diseases, sharing knowledge and defending science, has decided to leave X because ...

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Reposted by Arthur Lensen

Camila Valenzuela, PhD @kamovalenz.bsky.social · 09/01/2025

Happy to share our latest preprint on dormant #Salmonella and the role of SifA for intravacuolar nutrition! Thanks to all the co-authors!

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Reposted by Arthur Lensen

Typas Lab @typaslab.bsky.social · 16/12/2024

You want to learn about microbiology from a fantastic lineup of speakers on a beautiful Greek island? PhD students apply now for the @EMBO | @FEBSnews Lecture Course The New Microbiology! Registration: 1 Apr 2025 Course: 03 – 11 Sep 2025 | Spetses, Greece meetings.embo.org/event/25-new...

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