Alessandro Romanel @aromanel.bsky.social · 25/11/2025Huge kudos to @abio.bsky.social and Filippo Gastaldello, and our collaborators Gianluca Lattanzi and Davide Dalfovo. 030
Alessandro Romanel @aromanel.bsky.social · 25/11/2025🚨 Out in NAR @narjournal.bsky.social! Introducing HapScoreDB: a database of protein language model functional scores for haplotype-resolved protein sequences. 📄 Paper: doi.org/10.1093/nar/... 💻 DB: bcglab.cibio.unitn.it/hapscoredb #Bioinformatics #Genomics #ProteinLanguageModels #CompBiodoi.orgHapScoreDB: a database of protein language model functional scores for haplotype-resolved protein sequencesAbstract. Deciphering the functional effects of genetic variants, especially those inherited together on the same haplotype, remains a major challenge in h 162
Reposted by Alessandro RomanelFrancesco Cambuli @francesco-cambuli.bsky.social · 04/12/2024Our latest collaborative project co-led by Dario De Felice, Alessandro Alaimo, @bresdavide.bsky.social, and Andrea Lunardi at CIBIO UniTrento 🔬 🧫 🧬 We generated pro-luminal prostate organoid models and found that common FOXA1 cancer indels are loss-of-function www.embopress.org/doi/full/10....embopress.orgRarγ-Foxa1 signaling promotes luminal identity in prostate progenitors and is disrupted in prostate cancer | EMBO reportsimageimageLeveraging mouse adult prostate organoids reveals regulators of prostatic luminal lineage commitment. The androgen pathway together with retinoic acid/Rarγ/Foxa1 signaling programs luminal p... 053
Reposted by Alessandro RomanelDavide Bressan @bresdavide.bsky.social · 24/01/2025Are you looking for a tool to analyze ChIP-seq data with spike-in control? Check out SpikeFlow 👇 academic.oup.com/nargab/artic...academic.oup.comSpikeFlow: automated and flexible analysis of ChIP-Seq data with spike-in controlAbstract. ChIP with reference exogenous genome (ChIP-Rx) is widely used to study histone modification changes across different biological conditions. A key 031